Comparative Study of the Osteogenic Differentiation Potential of Adipose Tissue-Derived Stromal Cells and Dedifferentiated Adipose Cells of the Same Tissue Origin under Pro and Antioxidant Conditions.

Adipose tissue-derived stromal cells (ASCs) play an important role in various therapeutic approaches to bone regeneration. However, such applications become challenging when the obtained cells show a functional disorder, e.g.

Intermittent aortic cross-clamping for coronary artery bypass grafting: a review of a safe, fast, simple, and successful technique.

Since the very beginning of coronary artery bypass grafting, the search for optimal myocardial protection has fascinated both clinicians and basic researchers. This retrospective review of a large patient cohort aims to display the advantages of one of the protective procedures, namely simple, intermittent aortic cross-clamping (IAC). Thus, this review aims to significantly contribute to daily bypass surgery.

Fluoro-jade identification of cerebellar granule cell and purkinje cell death in the alpha1A calcium ion channel mutant mouse, leaner.

Cell death is a critical component of normal nervous system development; too little or too much results in abnormal development and function of the nervous system. The leaner mouse exhibits excessive, abnormal cerebellar granule cell and Purkinje cell death during postnatal development, which is a consequence of a mutated calcium ion channel subunit, alpha(1A). Previous studies have shown that leaner cerebellar Purkinje cells die in a specific pattern that appears to be influenced by functional and anatomical boundaries of the cerebellum.

Histomorphological studies of the distal internal thoracic artery which support its use for coronary artery bypass grafting.

The use of the internal thoracic artery (ITA) for myocardial revascularization in coronary artery disease increased because of its relative immunity to atherosclerotic obstruction. This study investigated the distal part of the vessel, the region of anastomosis by means of histology to focus the visualization of this region of interest. The histological examination of arterial segments showed minor intimal thickening in 48 out of 100 patients.

Tricuspid valve repair in right-sided endocarditis.

Background And Aims Of The Study: Tricuspid valve endocarditis traditionally has been treated with either valve resection or valve replacement. To avoid implantation of foreign material in an infected area and to circumvent anticoagulation, tricuspid valve repair was applied and the results assessed.

Methods: Tricuspid valve repair was performed in five patients with right-sided endocarditis.

[Principles of duplex ultrasound diagnosis of the internal thoracic artery].

Because of its better long term patency the internal thoracic artery has become the conduit of choice for myocardial revascularization. Thirty healthy young volunteers were investigated to prove the suitability of the duplex system for investigating the internal thoracic artery. The mean systolic peak flow velocity was 1.

Duplex sonography of the internal thoracic artery. Preoperative assessment.

Ultrasonic duplex scanning was used to examine 211 internal thoracic arteries. The investigating vessels were classified as normal, abnormal, and occluded. The results of the duplex examination were compared with angiography as the reference method.

Internal thoracic artery: prevalence of atherosclerotic changes.

Use of the internal thoracic artery for myocardial revascularization has regained general acceptance because it offers better long-term results than do venous conduits. The aim of this study was to ascertain the prevalence of atherosclerosis in the internal thoracic artery and to correlate the prevalence with other known risk factors. A total of 117 patients (male/female ratio 84:33; mean age 56.

Internal mammary artery bypass grafting in left main stenosis.

Internal mammary artery grafting to the left anterior descending artery gives higher long-term patency and improved survival as compared with venous grafts. Few data exist on the operative mortality and infarction rate in coronary artery bypass surgery when using this type of graft in high-risk groups, such as patients with left main stenosis. In 19 months, we studied 81 consecutive patients with left main stenosis who received a mammary artery graft to the left anterior descending artery as well as vein grafts to other vessels and found no excessive mortality or infarction rate.

Combined two-dimensional and Doppler echographic examination of internal mammary artery grafts from the supraclavicular fossa.

The noninvasive examination of internal mammary artery grafts is gaining importance with the increasing use of this vessel in the surgical treatment of coronary atherosclerosis of the left anterior descending artery. We studied 36 patients (37 internal mammary artery grafts) with combined two-dimensional and pulsed Doppler echography from the supraclavicular fossa. Adequate visualization and Doppler signals were obtained in 95% of arterial grafts.

[Diagnosis and therapy of sternoclavicular joint dislocation].

Luxation of the sternoclavicular joint is described on the basis of the case histories and progress of patients with this very rare form of injury who underwent surgical treatment on the Orthopedic Clinic of Düsseldorf University Hospital in the years 1978 to 1988. Four of the 6 patients in our study were subjected to a follow-up examination as out-patients. After preliminary remarks on the anatomical and biomechanical peculiarities of the sternoclavicular joint, the various types of luxation and the customary Allmann I-III classification for degree of severity are discussed.

Grafting with the internal mammary artery: correlation between preoperative angiography and intraoperative findings.

No data exist on the relation between angiography of the internal mammary artery and intraoperative findings during bypass surgery. We studied 47 consecutive patients and found no atherosclerotic changes. Intraoperatively, however, 4 left internal mammary arteries were judged unsuitable for grafting.

[Secondary impingement syndrome in athletes].

Dysfunction of the shoulder joint is based not only on anatomic conditions. The consideration of the special kinesiology of the shoulder helps to understand the shoulder pathology. This mainly applies to young "overhead athletes" like swimmers, handball-, basketball-, volleyball-, and racketplayers.

[Correlation of the degeneration of the AC joint (acromioclavicular) and rupture of the rotator cuff].

During the past various factors were quoted to be causative of a degeneration of the rotator cuff. In this study 122 shoulder specimen, aged 58-95 years, were dissected. A high correlation between severe degeneration of the ac-joint and rupture of the rotator cuff was found.

[Sternocostoclavicular hyperostosis].

On the basis of 4 patients from our own records we describe the rare syndrome of "Hyperostosis sternocostoclavicularis". The etiology of this disorder is still unclarified. In addition to a swelling that is generally only slightly tender to pressure, the most important symptom is usually a long-standing, intermittent, dull pain in the upper sternum, the claviculae and the adjacent uppermost ribs.

[Orthopedic aspects of Crohn disease. Examples of extra-intestinal organ manifestations].

Articular changes in Chron's disease represent extraintestinal organic manifestations which generally take the form of so-called enteropathic synovitis. Articular alterations - diagnosed as non-specific arthritis in the great majority of cases--may precede the intestinal disease. In very rare cases it can be shown that the joints display histological changes typical of Morbus Crohn.

[The disease picture of melorheostosis].

The rare syndrome of Lér's melorheostosis is described on the basis of a case encountered in one of our own patients, a 29 year old male patient. Particular attention is given to the symptoms, the specific results of clinical examination, and the differential diagnosis.

[Possibilities of sonography in patellar apex syndrome].

23 Patients suffering from jumper's knee were examined by sonography. Using ultrasound imaging, we demonstrated pathologic changes in the tendon. Reproducible documentation of the patella tendon was proved by using three specimens.

[The value of sonography in injuries of the knee joint].

In an experimental study we examined three knee specimens with regard to the value of ultrasound for imaging soft tissue structures. Subsequently we documented artificial lesions at the menisci and ligaments. With this experience we started a prospective study comparing the preoperative ultrasound investigation with the results of arthroscopy in 101 patients.

[Ultrasound determination of the humerus retrotorsion angle. An experimental and clinical study].

We examined the value of ultrasound to determine the retroversion of the humerus in an experimental and clinical study. In twenty human upper arms of corpses the retroversion angle was measured by ultrasound and by direct means using a paralellograph. The angle was also evaluated by sonography and CAT scan in 7 patients, and in 6 patients by sonography and x-ray.

Results of surgical treatment for acute pancreatitis.

The results following the surgical treatment of acute pancreatitis in 67 patients are presented. The male:female ratio was 1.5:1; the average age for all patients was approximately 54.

[Etiology of sub-acromial impingement syndrome--a biomechanical study].

Eight fresh shoulder specimen were dissected and the functional relationship of the rotator cuff tendons to the acromion was demonstrated through various arcs of shoulder motion. The scapula was fixed and the arm was elevated, rotated, and abducted by pulling the muscle tendon according to EMG activities. Using FUJI compression films the subacromial compression of the rotator cuff was measured.

[The value of sonography in assessing intracompartmental pressure in the anterior tibial compartment].

Fifty recreational athletes were subjected to a defined exercise programme (running on a treadmill, 8 km/h). The pressure in the middle third of the anterolateral compartment was measured. We also assessed the geometry and the echogenicity in the transversal and the longitudinal plane by sonographic means.