Publications by authors named "Sonoko Tasaki"
Article Synopsis
- Th17 cells play a crucial role in the immune response against oral pathogens, particularly in the development of periodontitis.
- The oral pathobiont Porphyromonas gingivalis exacerbates periodontitis by promoting Th17 cell differentiation, which occurs in Peyer's patches and allows these cells to migrate to oral tissues.
- The study shows that the intestinal microbiome influences Th17 cell response, with antibiotic treatment altering the microbiome potentially impacting the progression of periodontitis.
Article Synopsis
- Maternal immune activation (MIA) due to bacterial infection, specifically through lipopolysaccharide (LPS), can negatively impact fetal brain development and lead to autism spectrum disorder (ASD)-like behaviors in mouse offspring.
- This study shows that LPS exposure triggers an immune response marked by increased IL-17A levels and changes in immune cell activity both in the mother and the fetal brain.
- Blocking IL-17A in the context of LPS-induced MIA helped reduce the ASD-like behaviors in the offspring, highlighting the importance of the IL-17A pathway in this process.
We previously reported that Candida albicans responded to mild heat stress in a range of temperature elevations simulating fever, and concluded that mild heat stress increases susceptibility to antifungal drugs. In this study, we show that mild heat stress causes a morphological change in hyphae during the process of biofilm formation. We found that mild heat stress extended the period of hyphal stage maintenance in C.
View Article and Find Full Text PDFCandida albicans is a human commensal that causes opportunistic infections. Th17 cells provide resistance against mucosal infection with C. albicans; however, the T cell antigens remain little known.
View Article and Find Full Text PDFActivation of naive CD4 T cells results in the development of several distinct subsets of effector Th cells, including Th2 cells that play a pivotal role in allergic inflammation and helminthic infections. SWAP-70-like adapter of T cells (SLAT), also known as Def6 or IBP, is a guanine nucleotide exchange factor for small GTPases, which regulates CD4 T cell inflammatory responses by controlling Ca/NFAT signaling. In this study, we have identified a novel alternatively spliced isoform of SLAT, named SLAT2, which lacks the region encoded by exons 2-7 of the gene.
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