Publications by authors named "Sonoko Matsumoto"
Article Synopsis
- Francisella tularensis causes tularemia, a serious zoonotic disease in humans, largely by growing inside host cells, but the host factors aiding this growth remain largely unidentified.
- A screening of 368 compounds revealed 56 inhibitors that reduced the infection rate of F. novicida, with a particular focus on cucurbitacin I, which inhibits the JAK2/STAT3 signaling pathway.
- Both cucurbitacin I and another inhibitor, Stattic, decreased the bacterial load inside host cells but did not impact how the bacteria attach or grow inside, suggesting that the JAK2/STAT3 pathway is crucial for the bacteria's entry into cells, potentially through altering actin dynamics.
Paramecium is employed as a valuable model organism in various research fields since a large number of strains with different characteristics of size, morphology, degree of aging, and type of conjugation can be obtained. It is necessary to determine a method for the classification and simple identification of strains to increase their utility as a research tool. This study attempted to establish a polymerase chain reaction (PCR)-based method to differentiate strains of the same species.
View Article and Find Full Text PDFParamecium spp. are a genus of free-living protists that live mainly in freshwater environments. They are ciliates with high motility and phagocytosis and have been used to analyze cell motility and as a host model for pathogens.
View Article and Find Full Text PDFBackground: The sacroiliac joint (SIJ) is recognized as a potential source for low back pain especially in elderly people. Previous studies indicated that in patients with SIJ pain, posterior sacroiliac ligament injections are more effective than intra articular injections. The aim of this study was to assess usefulness of ultrasound sonography (US) in performing posterior sacroiliac ligament injection.
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- The study investigates how a sacroiliac joint block can help reduce chronic low back pain in elderly patients, who often experience complicated pain due to various spine issues.
- Researchers examined patients with hip and leg pain over the course of eight months, assessing pain locations using several clinical tests, leading to the use of local anesthetics for pain relief.
- Results indicated a significant reduction in pain, with over 50% improvement noted in 15 out of 24 patients, demonstrating the block's effectiveness for both pain management and diagnosis.
A 51-year-old woman was scheduled for emergency enterectomy and vascular repair under general anesthesia for active bleeding from internal iliac artery caused by repeated radiotherapy for cervical cancer and subsequent hypovolemic shock. For the first two hours of operation, the blood loss exceeded 6,000 ml and the hemoglobin level decreased to a low of 3.8 g x dl(-1) despite administration of 38 units of packed red cells.
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