Lifetime socioeconomic status and early life microbial environments predict adult blood telomere length in the Philippines.

Objectives: Psychosocial stress is postulated to hasten senescence in part by accelerating the shortening of telomere length (TL). One pathway through which this may happen is via increasing inflammation and innate immune system activation-a pathway which recent studies suggest acts more strongly for those who grew up in low microbial environments. Thus, we hypothesized that: (1) Psychosocial stress will be inversely associated with TL, (2) early life microbial environments will predict TL, and (3) microbial environments will moderate the association between psychosocial stress and TL.

Reproductive consequences of unwanted sexual debut among young adult women from Metro Cebu, Philippines.

The circumstances surrounding sexual debut influence subsequent sexual and reproductive outcomes. We analysed longitudinal data from 397 women who participated in the Cebu Longitudinal Health and Nutrition Survey in Cebu, Philippines, to examine associations between unwanted first sex and number of pregnancies, unintended pregnancy, and use of modern contraception. 72% of women reported unwanted first sex.

Androgen receptor polyglutamine repeat length (AR-CAGn) modulates the effect of testosterone on androgen-associated somatic traits in Filipino young adult men.

Objectives: The androgen receptor (AR) mediates expression of androgen-associated somatic traits such as muscle mass and strength. Within the human AR is a highly variable glutamine short-tandem repeat (AR-CAGn), and CAG repeat number has been inversely correlated to AR transcriptional activity in vitro. However, evidence for an attenuating effect of long AR-CAGn on androgen-associated somatic traits has been inconsistent in human populations.

Salivary estradiol and testosterone in Filipino men: Diurnal patterns and relationships with adiposity.

Objectives: We used detailed saliva sampling procedures to test for diurnal changes in men's salivary estradiol (E2) and testosterone (T) and assessed whether greater adiposity predicted higher E2 and T.

Methods: We drew on a subsample of young adults enrolled in a long-running birth cohort study in Metro Cebu, Philippines. Subjects provided saliva samples at four time points during the day (waking, waking +40 min, early evening, and bedtime), which were assayed for E2 and T.

Do testosterone declines during the transition to marriage and fatherhood relate to men's sexual behavior? Evidence from the Philippines.

Testosterone (T) is thought to help facilitate trade-offs between mating and parenting in humans. Across diverse cultural settings married men and fathers have lower T than other men and couples' sexual activity often declines during the first years of marriage and after having children. It is unknown whether these behavioral and hormonal changes are related.

Progesterone and estrogen responsiveness to father-toddler interaction.

Objectives: We assessed the responsiveness of salivary progesterone (P4) and estradiol (E2) to father-child interaction, including testing for differences in short-term hormonal change based on paternal characteristics. We also predicted that P4 exposure during the study period would relate positively to post-interaction paternal mood.

Methods: We conducted an in-home intervention study in which fathers (n = 44) played with their toddlers.

Does cosleeping contribute to lower testosterone levels in fathers? Evidence from the Philippines.

Because cross-species evidence suggests that high testosterone (T) may interfere with paternal investment, the relationships between men's transition to parenting and changes in their T are of growing interest. Studies of human males suggest that fathers who provide childcare often have lower T than uninvolved fathers, but no studies to date have evaluated how nighttime sleep proximity between fathers and their offspring may affect T. Using data collected in 2005 and 2009 from a sample of men (n = 362; age 26.

Age at menarche and parity are independently associated with Anti-Müllerian hormone, a marker of ovarian reserve, in Filipino young adult women.

Objectives: Despite ample evidence of variation in timing of menopause, little is known about the extent or underlying causes of individual variation in ovarian reserve and age-related follicular decline. Anti-Müllerian hormone (AMH), a hormonal marker of ovarian reserve, may be a useful tool to clarify these questions. We describe AMH in a cohort of Filipino young adult women, and evaluate whether ovarian reserve in early adulthood relates to measures of life history scheduling (menarcheal age) and reproductive effort (parity).

Short-term changes in fathers' hormones during father-child play: impacts of paternal attitudes and experience.

Hormonal differences between fathers and non-fathers may reflect an effect of paternal care on hormones. However, few studies have evaluated the hormonal responses of fathers after interacting with their offspring. Here we report results of a 30-minute in-home experiment in which Filipino fathers played with their toddlers and consider whether paternal experience and men's perceptions of themselves as fathers affect hormonal changes.

Testosterone, physical activity, and somatic outcomes among Filipino males.

Testosterone (T) facilitates male investment in reproduction in part through its anabolic effects on skeletal muscle. Traits like muscle and strength are energetically costly but are believed to enhance competitive ability in humans and other mammals. However, there are limited data on relationships between T and somatic outcomes in lean, non-western populations.