Reproduction in aging normal and neonatally androgenized female rats.

Decline in reproductive success was compared in normal and neonatally androgenized female rats permitted to receive 1 or 5 ejaculations during each of 7, 5, 3, or 1 mating test. Exposing the females to .5 microgram of testosterone propionate on Day 3 of life increased their age-related rate of decline in the number of successful pregnancies and offspring born in each litter as well as in behavioral receptivity.

Positive Feedback by Ovarian Hormones on Prolactin and LH in Old Versus Young Female Rats.

The purpose of this investigation was to determine whether any differences could be demonstrated in the ability of old versus young ovariectomized rats to release prolactin and LH in response to ovarian steroid administration. Female Long Evans rats 20-24 months of age and 4 months of age were ovariectomized. Fourteen days later, each rat was injected with estradiol benzoate, followed three days later by an injection of progesterone.

[A combined allogenic implant for the dorsum of the nose (author's transl)].

Report of three patients with small bony defects on the lateral bony wall or the bridge of the nose. Reconstruction was performed with a combined cushion like implant of lyodura polsted with merthiolate preserved allongene crashed cartilage. Over a follow up time period of two years the cosmetic results are good.

[Polyploidisation - a phenomenon of aging? (author's transl)].

By means of cytophotometric determination of DNA in different cellular systems an increase in polyploidisation correlated to age could be demonstrated. The latter is well demonstrable if compensatory hyperplasia or hypertrophy occurs. It is discussed that cellular systems of older individuals can increase their DNA - content, but they are not able to carry out a caryo-and cytocinesis.

[The vascularisation of the granulation tissue in different ages. - Its importance for wound healing (author's transl)].

The part of capillaries of a plastic sponge granuloma was determined in rats of different ages. It was found that granulation tissue of older rats contains significantly fewer capillaries than that of young animals. The diminished vascularisation of granulation tissue may be responsible for the deterioration of wound healing in aged individuals.

The influence of D-penicillamine on cell proliferation. II. Quantitative investigations during a chronic proliferative inflammation in a model granuloma.

The influence of D-penicillamine (DPA) on a defined chronic proliferative inflammation in a model granuloma was tested in a long-term experiment. A change in collagen metabolism was detected during the three weeks of DPA administration, whereas the proliferation of the fibroblast population remained unaffected.

The influence of D-penicillamine on cell proliferation. I. Quantitative investigations during an acute exudative inflammation in a model granuloma.

The influence of D-penicillamine (DPA) administration on a defined acute exudative inflammation in a model granuloma was investigated in a short-term experiment. The results indicate that DPA administration influences the metabolism of collagen but does not influence the proliferation behaviour of the fibroblasts. A significant increase in the number of fibroblasts can be explained in terms of an interaction of the loss of the soluble collagen with the number of fibroblasts necessary to maintain the total collagen level constant.

[Investigations regarding the pathogenesis of fibromatosis of the palmar fascia (Dupuytren's contracture) (author's transl)].

The palmar aponeuroses of five patients suffering from Duputyren's disease were examined by means of light and electron microscopy. In all cases myofibroblasts could be found in the alterated regions of the palmar aponeuroses. The role of the fibroblasts for the pathogenesis of the disease is discussed.

The effect of complete Freund--adjuvant on chronic proliferating inflammation in an experimental granuloma model.

Histometric, biochemical, radiochemical and autoradiographic studies were undertaken to investigate the influence of complete Freund-adjuvant (CFA) on a defined chronic proliferating inflammation of a granuloma model in two different experimental situations. Where as the percentage fraction of the fibroblasts, 3H-thymidine marking index of the fibroblasts and the impulse rate of the fibroblasts and endothelial cells do not differ from the values found for the control animals, both the protein and DNA content of the implanted sponges, as well as the DNA content of the individual fibroblasts in the implants increased, independent of the stage of the chronic proliferating inflammation at which the CFA was administered. Surprisingly the quantity of the fibroblast specific synthetic product, collagen, did not increase in proportion to the absolute number of fibroblasts, but remained either constant or even significantly decreased.