Eur J Gastroenterol Hepatol
July 2008
Background: Long-term therapy with potent acid inhibitors is a common treatment for gastro-esophageal reflux disease. Administration of proton pump inhibitors (PPIs) causes profound and continuous hypochlorhydria by inhibition of the proton pump in gastric parietal cells. Long-term hypergastrinaemia increases mucosal thickness and enterochromaffin-like cell density in oxyntic mucosa.
View Article and Find Full Text PDFThe presence of the organochlorine pesticide endosulfan in the water column confers a significant direct risk to the biota therein, yet relatively little is known regarding the toxic impact of dietborne endosulfan to aquatic organisms. Pre-smolt Atlantic salmon (Salmo salar) were fed at levels of technical endosulfan equal to the European Union regulatory limit (5 microg kg(-1)) and at levels 10 and 100 times greater, for a total of 49 days with haematology (e.g.
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