Publications by authors named "Sonja Vosbeck"
Article Synopsis
- Endothelial lipase (LIPG) is linked to breast cancer by promoting cell growth, tumor formation, and spread.
- Severe oxidative stress leads to an increase in LIPG levels, which causes breast cancer cells to accumulate lipid droplets, enhancing their survival under stress.
- High levels of LIPG in certain breast tumors correlate with poorer outcomes for patients, suggesting it plays a significant role in supporting cancer progression through lipid storage.
Alterations in lipid metabolism and in the lipid composition of cellular membranes are linked to the pathology of numerous diseases including cancer. However, the influence of oncogene expression on cellular lipid profile is currently unknown. In this work we analyzed changes in lipid profiles that are induced in the course of ERBB2-expression mediated premature senescence.
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