Publications by authors named "Sonja Musto"
Plasmid genomic epidemiology of carbapenemase-producing in Canada, 2010-2021.
Antimicrob Agents Chemother
December 2023
Article Synopsis
- Carbapenems are vital last-resort antibiotics against multidrug-resistant infections, but their effectiveness is threatened by the global rise of carbapenem-resistant bacteria due to carbapenemase genes.
- In Canada, a specific carbapenemase type has been identified as prevalent, capable of breaking down various antibiotics, and commonly found on mobile genetic elements like plasmids and transposons.
- Through whole genome sequencing of 829 carbapenemase-producing isolates from 2010 to 2021, researchers discovered diverse plasmid clusters responsible for resistance spread, revealing both clonal and horizontal transmission patterns across different bacterial strains in Canada.