Publications by authors named "Sonja Mader"
Cancer patients usually receive therapies according to their primary tumor's molecular traits. These characteristics may change during the molecular evolution of distant metastases as the leading cause of cancer deaths. Primary tumor tissue, if accessible at all, does not always provide enough information to stratify individual patients to the most promising therapy.
View Article and Find Full Text PDFEpithelial-to-Mesenchymal Transition (EMT) is a complex process that supports the migratory capacity of epithelial tumor cells and is thought to play a crucial role in promoting cancer metastasis. Despite the wealth of experimental data, the exact role of EMT in cancer patients remains more controversial. Over the past 10 years, sensitive technologies that allow the detection and molecular characterization of circulating tumor cells (CTCs) in the peripheral blood of tumor patients have been developed.
View Article and Find Full Text PDFArticle Synopsis
- Antibody glycosylation plays a crucial role in improving antibody therapeutics, and this study focuses on producing the anti-cancer monoclonal antibody rituximab using the unicellular ciliate Tetrahymena thermophila.
- The produced antibody showed increased efficacy in antibody-dependent cell-mediated cytotoxicity due to unique N-linked glycosylation patterns, including afucosylated and oligomannose-type glycans.
- Analyses suggest that the glycosylation structures in the ciliate closely mimic human glycoproteins and demonstrate potential for large-scale production of monoclonal antibodies with enhanced therapeutic properties.