Publications by Sonja M Pritchett | LitMetric

Publications by authors named "Sonja M Pritchett"

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Human X-chromosome inactivation pattern distributions fit a model of genetically influenced choice better than models of completely random choice.

Nisa K E Renault Sonja M Pritchett Robin E Howell Wenda L Greer Carmen Sapienza

Eur J Hum Genet

December 2013

Article Synopsis

In eutherian mammals, X-chromosome inactivation (XCI) silences one of the two X-chromosomes in females, creating functional mosaicism where cells express genes from either the maternal or paternal X-chromosome.
Research explores whether the choice of which X-chromosome to inactivate is random or genetically influenced, with implications for health in females.
Statistical analysis of XCI patterns in populations from Denmark and Utah indicates that genetically influenced choice models fit the data better than random choice models.

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