Publications by authors named "Sonja Lorean Plasil"
Large-scale characterization of cocaine addiction-like behaviors reveals that escalation of intake, aversion-resistant responding, and breaking-points are highly correlated measures of the same construct.
Giordano de Guglielmo Lieselot Carrette Marsida Kallupi Molly Brennan Brent Boomhower Sonja Lorean Plasil
Elife
November 2024
Article Synopsis
- Addiction involves increased drug use, compulsive seeking, and continued use despite harm, but why some users progress to this point isn't well understood, especially concerning sex differences.
- A study with over 500 diverse rats examining cocaine self-administration revealed that increased drug intake, persistence despite negative consequences, and reward-seeking were interconnected, while irritability during withdrawal stood apart.
- The research found that female rats showed more addiction-like behaviors and fewer resilient traits compared to males, indicating significant sex differences in addiction resilience.