Publications by authors named "Sonja L B Arneaud"

Article Synopsis
  • Dopaminergic neurons are particularly vulnerable to trauma-induced neurodegeneration, a trait observed in various species from nematodes to humans.
  • The research highlights that dopamine, which plays a crucial role in Parkinson's disease, becomes toxic during injuries, especially when produced outside its usual neurons.
  • An imbalance in dopamine levels due to trauma leads to cell damage, and this vulnerability is intensified by an increase in a key enzyme for dopamine production triggered by the FOS-1 transcription factor.
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Cells sense stress and initiate response pathways to maintain lipid and protein homeostasis. However, the interplay between these adaptive mechanisms is unclear. Herein, we demonstrate how imbalances in cytosolic protein homeostasis affect intracellular lipid surveillance.

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Aging is a complex and highly regulated process of interwoven signaling mechanisms. As an ancient transcriptional regulator of thermal adaptation and protein homeostasis, the Heat Shock Factor, HSF-1, has evolved functions within the nervous system to control age progression; however, the molecular details and signaling dynamics by which HSF-1 modulates age across tissues remain unclear. Herein, we report a nonautonomous mode of age regulation by HSF-1 in the Caenorhabditis elegans nervous system that works through the bone morphogenic protein, BMP, signaling pathway to modulate membrane trafficking in peripheral tissues.

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Imbalances in lipid homeostasis can have deleterious effects on health. Yet how cells sense metabolic demand due to lipid depletion and respond by increasing nutrient absorption remains unclear. Here we describe a mechanism for intracellular lipid surveillance in Caenorhabditis elegans that involves transcriptional inactivation of the nuclear hormone receptor NHR-49 through its cytosolic sequestration to endocytic vesicles via geranylgeranyl conjugation to the small G protein RAB-11.

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Mechanical stimuli initiate adaptive signal transduction pathways, yet exceeding the cellular capacity to withstand physical stress results in death. The molecular mechanisms underlying trauma-induced degeneration remain unclear. In the nematode C.

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Age-associated decay of intercellular interactions impairs the cells' capacity to tightly associate within tissues and form a functional barrier. This barrier dysfunction compromises organ physiology and contributes to systemic failure. The actin cytoskeleton represents a key determinant in maintaining tissue architecture.

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Article Synopsis
  • Advances in genetic sequencing and analysis have revealed links between genetics and various diseases, but targeting specific diseases remains complex due to overlapping cellular mechanisms.
  • Different research fields may interpret the same biological processes differently, but collaboration between them is crucial to fully understand these mechanisms for better translational science.
  • A case study on stress response pathways highlights conflicting approaches in treating degenerative diseases versus cancer, suggesting that biases in scientific perspectives can influence therapeutic strategies.
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Article Synopsis
  • Podophyllotoxin (PPT) is a crucial plant compound used to create many cancer treatment drugs, prompting researchers to find alternative sources due to limited plant availability.
  • This study focuses on the endophytic fungus Phialocephala podophylli, which was found to produce PPT and investigates the SD gene involved in its biosynthesis.
  • By successfully amplifying and expressing the SD gene and confirming its functionality, this research lays the foundation for understanding the entire PPT biosynthetic pathway in a different organism, Pichia pastoris.
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