Sensitivity and specificity analysis of fringing-field dielectric spectroscopy applied to a multi-layer system modelling the human skin.

The sensitivity and specificity of dielectric spectroscopy for the detection of dielectric changes inside a multi-layered structure is investigated. We focus on providing a base for sensing physiological changes in the human skin, i.e.

Towards a realistic dielectric tissue model: a multiscale approach.

In the past, mainly analytical mixing formulas were used for modeling of dielectric properties of biological cells. General drawbacks of such formulas are the restriction to simple shapes and small cellular volume fractions. Assuming cell suspensions or tissues being quasi-periodic the problem size can be reduced to a cubic unit cell containing a single biological cell.

Validation of human skin models in the MHz region.

The human skin consists of several layers with distinct dielectric properties. Resolving the impact of changes in dielectric parameters of skin layers and predicting them allows for non-invasive sensing in medical diagnosis. So far no complete skin and underlying tissue model is available for this purpose in the MHz range.

Nanoparticle-mediated electron transfer across ultrathin self-assembled films.

The electrochemical behavior of arrays of Au nanoparticles assembled on Au electrodes modified by 11-mercaptoundecanoic acid (MUA) and poly-L-lysine (PLYS) was investigated as a function of the particle number density. The self-assembled MUA and PLYS layers formed compact ultrathin films with a low density of defects as examined by scanning tunneling microscopy. The electrostatic adsorption of Au particles of 19 +/- 3 nm on the PLYS layer resulted in randomly distributed arrays in which the particle number density is controlled by the adsorption time.