Publications by authors named "Sonita A P Siboro"
Article Synopsis
- The study investigates how the porosity of alginate hydrogels affects drug release, with two different formulations created using distinct crosslinkers.
- The results revealed that the porous hydrogel (Alg-Nb) allowed for faster drug release due to its adjustable porosity, while the non-porous hydrogel (Alg-FA) released drugs slowly.
- Notably, the porous hydrogels demonstrated the ability to sustainably release the drug doxorubicin over a period of 35 days.
In this article, a drug delivery system with a near-infrared (NIR) light-responsive feature was successfully prepared using a block copolymer poly(ethylene oxide)--poly(glycidyl methacrylate)-azide (PEO--PGMA-N) and a cross-linker containing a Se-Se bond through "click" chemistry. Doxorubicin (DOX) was loaded into the core-cross-linked (CCL) micelles of the block copolymer along with indocyanine green (ICG) as a generator of reactive oxygen species (ROS). During NIR light exposure, ROS were generated by ICG and attacked the Se-Se bond of the cross-linker, leading to de-crosslinking of the CCL micelles.
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