Three-dimensional structure and IgE-binding properties of mature fully active Der p 1, a clinically relevant major allergen.

Background: Der p 1 is a 25-kd allergen with cysteine protease activity. Sensitization to Der p 1 affects a large proportion of individuals with allergy, resulting in rhinitis, asthma, and/or atopic dermatitis.

Objective: We determined the Der p 1 crystallographic structure to understand the relationships among structure, function, and allergenicity.