The Association of Thyroid-Stimulating Hormone (TSH) Levels and Lipid Profile in Euthyroid Patients with Familial Hypercholesterolemia.

Previous studies reported a relationship between thyroid-stimulating hormone (TSH) and low-density lipoprotein cholesterol (LDL-C) levels. In this study, we aim to evaluate the impact of TSH levels on lipid profile in patients with familial hypercholesterolemia (FH) and euthyroid state. Patients were selected from the Isfahan FH registry.

Apolipoprotein B gene mutation related to familial hypercholesterolemia in an Iranian population: With or without hypothyroidism.

Background: Familial hypercholesterolemia (FH) leads to elevated low-density lipoprotein cholesterol (LDL-C) levels in plasma. Mutations of its related gene; apolipoprotein B (APOB) is seen in about two percent of the patient with FH. Thyroid disease is usually part of the exclusion criteria for the detection of FH which alters the lipid profile.

Familial Hypercholesterolemia (FH) in Iran: Findings from the Four-Year FH Registry.

Background: Familial hypercholesterolemia (FH) is a common autosomal dominant disease. Its diagnosis in Iran was uncommon. Iran registry of FH (IRFH) has been started from 2017 from Isfahan.

CASCADE screening and registry of familial hypercholesterolemia in Iran: Rationale and design.

Background: Familial hypercholesterolemia (FH) is one of the most common genetic disorders, which leads to premature coronary artery disease (CAD). It has been suggested that heterozygous FH affects around 1:250 to 1:500 in the general population or even more than this, and homozygous FH affects 1:1000000 of the population. If patients with FH are not diagnosed and treated early in life, many of them will develop premature CAD event.

The sustainability of interventions of a community-based trial on children and adolescents' healthy lifestyle.

Background: Sustainability is the core of a successful health-related intervention program. This study was conducted to evaluate the sustainability of interventions of the Heart Health Promotion from Childhood (HHPC) project, one of the 10 interventional projects of the Isfahan Healthy Heart Program.

Methods: The evaluation of HHPC included administrating surveys to 500 elementary and middle, and 500 high school students.

Differences in the prevalence of metabolic syndrome in boys and girls based on various definitions.

Background: The prevalence of metabolic syndrome (MetS) is increasing among children and adolescents. However, the prevalence of this disorder varies based on its different definitions. This study aimed to determine the prevalence of MetS in Iranian adolescents in junior high and high schools according to the definitions provided by the International Diabetes Federation (IDF) and De Ferranti.

Parental perceptions of weight status of their children.

Background: Understanding the knowledge, attitudes, and beliefs of parents is important for planning appropriately to control their children's weight. We aimed to study these variables in parents of normal, underweight, overweight, and obese children.

Methods: This cross-sectional study targeted the parents of normal, underweight, overweight, and obese children, who were selected using multistage random sampling method.

Impact of a community-based lifestyle intervention program on blood pressure and salt intake of normotensive adult population in a developing country.

Background: Data on the effect of lifestyle intervention programs on salt intake and blood pressure in developing countries are scarce. This study aimed to assess the impact of a healthy lifestyle community-based trial on salt intake and blood pressure among a representative sample of normotensive Iranian adults.

Materials And Methods: We compared the data for salt intake, urinary sodium levels and blood pressure from three cross-sectional surveys in time points of 1999, 2001-2002 (beginning of the community interventions), and 2007 (after the community trial) for normotensive adult population of Isfahan, Iran in the framework of Isfahan Healthy Heart Program.

The Relationship between Weight and CVD Risk Factors in a Sample Population from Central Iran (Based on IHHP).

Background: Atherosclerosis is one of the leading causes of mortality all around the world. Obesity is an independent risk factor for atherosclerosis and cardiovascular diseases (CVD). In this respect, we decided to examine the effect of the subgroups of weight on cardiovascular risk factors.

Association between cigarette smoking and socio-demographics, lifestyle and mental health factors in a sampled Iranian population.

The objective of this study was to evaluate associations between cigarette smoking and socio-economic variable in an Iranian male population. Isfahan Healthy Heart Program (IHHP) is a community oriented health study from which we obtained our data regarding male subjects. Socio-demographic variables--sex, age, marital status, educational level, occupation, and income--and physical activity level were derived from the questionnaire.

The impact of obesity on hypertension and diabetes control following healthy Lifestyle Intervention Program in a developing country setting.

Background: The aim of this study was to evaluate the impact of obesity and overweight on diabetes mellitus (DM) and hypertension (HTN) control in a healthy lifestyle intervention program in Iran.

Methods: Within the framework of the Isfahan Healthy Heart Program (IHHP), a community trial that was conducted to prevent and control cardiovascular disease and its risk factors, two intervention counties (Isfahan and Najafabad) and one reference county (Arak) were selected. Demographic information, medical history, anti-diabetic and anti-hypertensive medications use were asked by trained interviewers in addition to physical examination and laboratory tests for 12514 adults aged more than 19 years in 2001 and were repeated for 9572 adults in 2007.

Metabolic syndrome and health-related quality of life in Iranian population.

Background: To investigate the association between Metabolic syndrome (MetS) and Health related quality of life (QoL) in Iranian population.

Methods: We used data from the post-intervention phase of Isfahan Healthy Heart Program (IHHP), a community trial for cardiovascular disease (CVD) prevention and control. We recruited 9570 healthy adults, aged ≥ 19 years who were randomly selected using multistage random sampling method.

Gender differences in obesogenic behaviour, socioeconomic and metabolic factors in a population-based sample of Iranians: the IHHP study.

This study investigated the gender differences in association of some behavioural and socioeconomic factors with obesity indices in a population-based sample of 12,514 Iranian adults. The mean body mass index (BMI), waist circumference (WC), and the waist-to-hip ratio (WHR) were significantly higher in women than in men. Current and passive smoking had an inverse association with BMI among males whereas current smoking, transportation by a private car, and longer duration of watching television (TV) had a positive association with BMI among females.

How can the results of a qualitative process evaluation be applied in management, improvement and modification of a preventive community trial? The IHHP Study.

Background: This study reports the results of the qualitative process evaluation (PE) of the Isfahan Healthy Heart Program (IHHP), an integrated community-based trial for prevention and control of non-communicable diseases in Iran.

Methods: The study explored the overall quality of program implementation. The participants, including designers of IHHP, stakeholders and community members (n = 60) were purposefully recruited from the intervention areas.