The effect of direct-to-consumer genetic tests on anticipated affect and health-seeking behaviors: a pilot survey.

Purpose: Numerous websites offer direct-to-consumer (DTC) genetic testing, yet it is unknown how individuals will react to genetic risk profiles online. The objective of this study was to determine the feasibility of using a web-based survey and conjoint methods to elicit individuals' interpretations of genetic risk profiles by their anticipated worry/anxiousness and health-seeking behaviors.

Methods: A web-based survey was developed using conjoint methods.

Economic evaluation of biologic therapies for the treatment of moderate to severe psoriasis in the United States.

Background: New biologic therapies are available for moderate to severe psoriasis.

Objective: To determine the most cost-effective sequence of biologic treatments.

Methods: Through modeling of the clinical pathway of biologic agents, adalimumab, alefacept, efalizumab, etanercept, and infliximab, the costs and benefits (quality-adjusted life-years [QALYs]) were determined.

Treatment of very early rheumatoid arthritis with symptomatic therapy, disease-modifying antirheumatic drugs, or biologic agents: a cost-effectiveness analysis.

Background: Long-term control or remission of rheumatoid arthritis (RA) may be possible with very early treatment. However, no optimal first therapeutic strategy has been determined.

Objective: To assess the potential cost-effectiveness of major therapeutic strategies for very early RA.

Efficacy of systemic treatments for moderate to severe plaque psoriasis: systematic review and meta-analysis.

Aims: To compare the efficacy of psoriasis treatments through a systematic literature review and meta-analysis.

Methods: Randomized controlled trials evaluating the Psoriasis Area and Severity Index (PASI) were identified and assessed for quality. PASI responses were modeled using a mixed-treatment comparison, which enabled the estimation of the relative effectiveness of several treatments.