The leukocyte chemotactic receptor FPR1 is functionally expressed on human lens epithelial cells.

Background: Lens degeneration in Fpr1(-/-) mice prompted us to search for functional FPR1 expression directly on lens epithelial cells.

Results: FPR1 is functionally expressed on human lens epithelial cells but has atypical properties compared with hematopoietic cell FPR1.

Conclusion: Lens epithelial cell FPR1 may be involved in development and maintenance of the lens.