Publications by authors named "Sonia Poddar"
Article Synopsis
- This study analyzed genetic diversity in 12 innate immune system genes among 171 individuals from eastern India, revealing a high level of novel DNA variants.
- Almost half of the 548 discovered DNA variants were new, and comparisons with reference sequences indicated signs of natural selection, likely due to the high pathogen exposure in the region.
- The study found significant differences in genetic variation compared to other populations, with innate immunity genes exhibiting a SNP density greater than the highest reported for any autosomal chromosome, highlighting the impact of natural selection on this population.
The main source of environmental arsenic exposure in most populations is drinking water in which inorganic forms of arsenic predominate. The single-cell gel electrophoresis technique (the comet assay) measures DNA damage, including double-strand and single-strand breaks, in somatic cells after a variety of genotoxic insults. We have used this method to measure damage to cellular DNA in the bone marrow and testicular cells of mice using the alkaline comet assay for the former and neutral comet assay for the latter.
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