Publications by authors named "Sonia Mara Nunes Silva"
Predicting SARS-CoV-2 Variant Spread in a Completely Seropositive Population Using Semi-Quantitative Antibody Measurements in Blood Donors.
Vaccines (Basel)
August 2022
SARS-CoV-2 serologic surveys estimate the proportion of the population with antibodies against historical variants, which nears 100% in many settings. New approaches are required to fully exploit serosurvey data. Using a SARS-CoV-2 anti-Spike (S) protein chemiluminescent microparticle assay, we attained a semi-quantitative measurement of population IgG titers in serial cross-sectional monthly samples of blood donations across seven Brazilian state capitals (March 2021−November 2021).
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- This study analyzed data from over 3.3 million blood donations in Minas Gerais, Brazil, from 2006 to 2017, focusing on the prevalence of HTLV positivity in blood donors.
- The overall frequency of HTLV-positive donations was low at 0.012%, with a higher prevalence found among first-time female donors compared to males and older first-time donors having greater infection odds.
- Notably, there was a significant decline in HTLV-positive donations during the study period, attributed to an increase in the proportion of repeat donors, highlighting the importance of repeat donors in minimizing transfusion-transmitted infections.
Introduction: HTLV-1/2 screening among blood donors commonly utilizes an enzyme-linked immunosorbent assay (EIA), followed by a confirmatory method such as Western blot (WB) if the EIA is positive. However, this algorithm yields a high rate of inconclusive results, and is expensive.
Methods: Two qualitative real-time PCR assays were developed to detect HTLV-1 and 2, and a total of 318 samples were tested (152 blood donors, 108 asymptomatic carriers, 26 HAM/TSP patients and 30 seronegative individuals).