Publications by authors named "Sonia El-Guendi"
Non-coding RNAs (ncRNA) represent 1/5 of the mammalian transcript number, and 90% of the genome length is transcribed. Many ncRNAs play a role in cancer. Among them, non-coding natural antisense transcripts (ncNAT) are RNA sequences that are complementary and overlapping to those of either protein-coding (PCT) or non-coding transcripts.
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- The genomic profile of multiple myeloma (MM) categorizes patients into two groups: a favorable hyperdiploid group and an unfavorable nonhyperdiploid group, but this classification misses other important factors affecting prognosis.
- A study of 162 patients revealed high occurrences of X chromosome alterations, particularly partial Xq duplication linked to inactive X deletion in females, which may indicate aneuploidy and high chromosomal breakage rates.
- Patients with significant chromosomal breakage generally had reduced survival rates, with certain genes in the altered regions, such as IKBKG and IRAK1, having potential roles in cancer and being important targets for specific MM treatments.
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- The BRCA1 gene is crucial in triple negative breast cancer (TNBC), with its expression loss linked to various mechanisms, and the study aimed to identify new prognostic factors related to BRCA1.
- The study analyzed BRCA1 protein and mRNA expression, promoter methylation, and the impact of specific microRNAs in TNBC samples from 69 patients.
- miR-548c-5p emerged as a novel independent prognostic factor, and combining its expression with tumor characteristics successfully predicted relapse in patients, while traditional BRCA1 expression measures did not correlate with patient outcomes.
Background: Germline mutations in breast cancer susceptibility gene 1 (BRCA1) increase the risk of breast and ovarian cancers. However, no association between BRCA1 germline mutation and glioblastoma malignancy has ever been highlighted. Here we report two cases of BRCA1 mutated patients who developed a glioblastoma multiform (GBM).
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