Publications by authors named "Sonia Dugue-Pujol"

We investigated in vivo catabolism of apolipoprotein A-II (apo A-II), a major determinant of plasma HDL levels. Like apoA-I, murine apoA-II (mapoA-II) and human apoA-II (hapoA-II) were reabsorbed in the first segment of kidney proximal tubules of control and hapoA-II-transgenic mice, respectively. ApoA-II colocalized in brush border membranes with cubilin and megalin (the apoA-I receptor and coreceptor, respectively), with mapoA-I in intracellular vesicles of tubular epithelial cells, and was targeted to lysosomes, suggestive of degradation.

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Article Synopsis
  • Transgenic mice expressing human apolipoprotein A-II (hapoA-II) exhibit key traits of metabolic syndrome, including high triglyceride levels and low HDL levels.
  • Hypertriglyceridemia in these mice is caused by the inhibition of lipoprotein lipase and hepatic lipase functions due to hapoA-II present on triglyceride-rich lipoproteins (TRLs).
  • The study demonstrated that the presence of hapoA-II affects the clearance of TRLs from the plasma, resulting in their accumulation, which is linked to postprandial hypertriglyceridemia.
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Type 2 diabetic patients present high triglyceride and low HDL levels, significant determinants for the risk of atherosclerosis. Transgenic mice overproducing human apolipoprotein (apo)A-II, one of the two major apos of HDLs, display the same lipid disorders. Here, we investigated the possible regulation of apoA-II gene expression by glucose.

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