Publications by authors named "Sonia Bolshakova"
Article Synopsis
- - Fast-spiking parvalbumin (PV)-positive cells are crucial for regulating activity in pyramidal neurons, and their malfunction is linked to various brain diseases.
- - Researchers created a transgenic model to study the effects of overexpressing a schizophrenia-related gene in PV cells, revealing gender-specific changes in anxiety behavior and impairments in synaptic function in the prefrontal cortex (PFC).
- - A computational model showed that these impairments lead to increased neural activity and communication issues, highlighting that disruptions in fast-spiking neurons are particularly harmful for circuits related to anxiety-like behavior.
Fast-spiking parvalbumin (PV)-positive cells are key players in orchestrating pyramidal neuron activity, and their dysfunction is consistently observed in myriad brain diseases. To understand how immune complement dysregulation - a prevalent locus of brain disease etiology - in PV cells may drive disease pathogenesis, we have developed a transgenic mouse line that permits cell-type specific overexpression of the schizophrenia-associated complement component 4 () gene. We found that overexpression of mouse () in PV cells causes sex-specific behavioral alterations and concomitant deficits in synaptic connectivity and excitability of PV cells of the prefrontal cortex.
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