Publications by authors named "Sonia Ammu"
Article Synopsis
- Proteasome inhibitors, such as carfilzomib, enhance the effectiveness of selinexor, a new oral treatment, in battling multiple myeloma (MM) based on preclinical studies.
- A clinical trial involving 32 patients assessed the safety, maximum-tolerated dose (MTD), and efficacy of selinexor combined with carfilzomib and dexamethasone, finding significant adverse effects but manageable under supportive care.
- The combination treatment led to an impressive 78% overall response rate, with a median progression-free survival of 15 months, indicating that weekly XKd is both effective and well-tolerated for relapsed refractory MM patients.
Chemotactic signals are relayed to neighboring cells through the secretion of additional chemoattractants. We previously showed in that the adenylyl cyclase A, which synthesizes the chemoattractant cyclic adenosine monophosphate (cAMP), is present in the intraluminal vesicles of multivesicular bodies (MVBs) that coalesce at the back of cells. Using ultrastructural reconstructions, we now show that ACA-containing MVBs release their contents to attract neighboring cells.
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