Effect of protonation induced distortions on the spectral properties and electronic structure of Octaphenylporphyrins: UV-vis, electrochemical, VT-NMR and ab initio studies.

The extent of conformational alteration of the porphyrin macrocycle during the course of protonation was observed, both experimentally and theoretically. For synthesized β-substituted octaphenylporphyrin (OPP) ring systems this macrocyclic distortions have been investigated by spectroscopic and computational analysis. Protonation induced nonplanarity in macrocyclic system is experimentally observed in a single step during spectrophotometric titration.

A Descriptive Cross-Sectional Study on Clinical Epidemiology of Different Types of Cancer in a Tertiary Care Centre: Insights From Eastern India.

Background and aim Cancer poses a significant burden in India, with a considerable number of people living with the disease and a substantial increase in new cases every year. Hence, considering the unique challenges faced by developing nations regarding the disease burden, this study has been designed. The aim of this work was to carry out a descriptive retrospective cross-sectional study on various types of cancer conducted in a tertiary care centre in India.

Factors Influencing the Consumption of Tobacco amongst the Khasi Indigenous People in Northeast India.

Background: Tobacco use in any form is a major public health concern. It accounts for nearly 1.35 million deaths every year.

Insights into the mechanism of binding of doxorubicin and a chlorin compound with 22-mer c-Myc G quadruplex.

Background: The interaction of small molecules with G quadruplexes is in focus due to its role in molecular recognition and therapeutic drug design. Stabilization of G-quadruplex structures in the promoter regions of oncogenes by small molecule binding has been demonstrated as a potential approach for cancer therapy.

Methods: In this study, electronic spectroscopy (ultraviolet-visible, fluorescence, circular dichroism), differential scanning calorimetry, and molecular modeling were employed to explore the interactions between the chemotherapy drug doxorubicin and a chlorin compound 5,10,15,20-tetraphenyl-[2,3]-[bis(carboxy)-methano]chlorin (HTPC(DAC)), and the c-Myc 22-mer G quadruplex DNA.

Insights into the Potential of Biopolymeric Aerogels as an Advanced Soil-Fertilizer Delivery Systems.

Soil fertilizers have the potential to significantly increase crop yields and improve plant health by providing essential nutrients to the soil. The use of fertilizers can also help to improve soil structure and fertility, leading to more resilient and sustainable agricultural systems. However, overuse or improper use of fertilizers can lead to soil degradation, which can reduce soil fertility, decrease crop yields, and damage ecosystems.

Emergence of Mycobacterium orygis-Associated Tuberculosis in Wild Ruminants, India.

Tuberculosis caused by Mycobacterium orygis was detected in 2 spotted deer from a wildlife sanctuary in western India and an Indian bison from a national park in central India. Nationwide surveillance is urgently required to clarify the epidemiology of the Mycobacterium tuberculosis complex at the human-livestock-wildlife interface.

Optimization of Selective Laser Melting Parameter for Invar Material by Using JAYA Algorithm: Comparison with TLBO, GA and JAYA.

In this study, the hardness and surface roughness of selective laser-melted parts have been evaluated by considering a wide variety of input parameters. The Invar-36 has been considered a workpiece material that is mainly used in the aerospace industry for making parts as well as widely used in bimetallic thermostats. It is the mechanical properties and metallurgical properties of parts that drive the final product's quality in today's competitive marketplace.

Effect of Metal-Cored Filler Wire on Surface Morphology and Micro-Hardness of Regulated Metal Deposition Welded ASTM A387-Gr.11-Cl.2 Steel Plates.

Environmental and human-friendly welding is the need of the hour. In this context, this study explores the application of the regulated metal deposition (RMD) technique for ASTM A387-Gr.11-Cl.

A double blind randomized controlled trial to evaluate the efficacy of green tea in gingivitis.

Gingivitis is the most common form of oral disease especially among patients undergoing fixed orthodontic treatment. Green tea, which is extensively used in Asian countries, can help to improve the overall gingival health, which can be assessed by using the gingival indices. Evaluation of the effectiveness of green tea on the gingival health of patients undergoing Orthodontic treatment is of interest.

Incidence, Clinical Features, and Outcomes of Transient Tachypnea of the Newborn at a Tertiary Care Center in Western India.

Background Transient tachypnea of the newborn (TTN) is a self-limiting, benign condition leading to respiratory distress shortly after birth. It is among the leading cause of respiratory distress in term and late preterm neonates. The disease is transient and resolves by three to four days in most neonates.

Development of a pH-sensitive functionalized metal organic framework: study for simultaneous delivery of doxorubicin and cyclophosphamide in breast cancer.

Exploration of an efficient dual-drug based nanocarrier with high drug loading capacity, specific targeting properties, and long-term stability is highly desirable in cancer therapy. Metal-organic frameworks (MOFs) have proven to be a promising class of drug carriers due to their high porosity, crystalline properties with defined structure information, and their potential for further functionalization. To enhance the drug efficacy as well as to overcome the burst effect of drugs, here we synthesized a pH responsive folic acid (FA) and graphene oxide (GO) decorated zeolitical imidazolate frameworks-8 (GO-FA/ZIF-8), for targeted delivery of doxorubicin (DOX) and cyclophosphamide (CP), simultaneously.

Schleichera oleosa Seed Extract Reduced the Proliferation of Breast Cancer by Regulating the BRCA1 and p16 Genes.

Background: Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death in females worldwide. Schleichera oleosa (kusum tree) belongs to the Sapindaceae family commonly found in many states of India. This plant is traditionally being used in various pathological conditions.

Microleakage at Implant Abutment and Prosthesis Interface in Cemented Implant-Supported Prosthesis.

Background: Dental implants have an important role in mainstream dental practice today to restore esthetics. The present study was conducted to evaluate the microleakage at implant abutment and prosthesis interface in cemented implant-supported prosthesis.

Materials And Methods: The present study comprised sixty replicas of abutment analog with length 5 mm, width of platform 4.

Assessment of the Survival of a Single Implant-Supported Cantilever Prosthesis in the Anterior Mandible.

Background: Implant dentistry has seen rapid and remarkable progress in recent years. The present study assessed the survival of a single implant-supported cantilever prosthesis (ISCP) in the anterior mandible.

Materials And Methods: Sixty-four patients with missing mandibular anterior teeth of both genders were provided with a single implant and restored with cantilever screw-retained prosthesis.

Effectiveness of Platelet-Rich Fibrin in the Treatment of Intrabony Defects with or Without Bone Graft: A Clinical Comparative Study.

Background: Periodontal diseases are a group of inflammatory diseases causing alveolar bone loss and eventually leading to loss of teeth. The present study was evaluated the effectiveness of platelet-rich fibrin (PRF) in the treatment of intrabony defects with or without bone graft.

Materials And Methods: Thirty subjects with the presence of intrabony defects were enrolled.

Comparison between Different Shades of Monolithic Zirconia over Microhardness and Water Solubility and Sorption of Dual-cure Resin Cement.

Aim And Objective: To compare the different shades of monolithic zirconia over microhardness and water solubility and water sorption of dual-cure resin cement.

Materials And Methods: Eighty specimens were included in the study. They were categorized into four categories having 20 samples each.

Evaluation of Effectiveness of Three New Gingival Retraction Systems: A Comparative Study.

Aim: To analyze the clinical effectiveness of three new gingival retraction systems: knitted retraction cord, expanding polyvinyl siloxane, and aluminium chloride containing paste.

Materials And Methods: Twenty patients were enrolled with age-group of more than 18 years and who required fixed prosthesis with minimum of two abutments. A preliminary impression of the arch was made with a stock metal tray and irreversible hydrocolloid impression material.

Comparison of efficacy of lignocaine, ropivacaine, and bupivacaine in pain control during extraction of mandibular posterior teeth.

Background: The management of pain during extraction of mandibular third molars is an important requisite to achieve patient comfort and to obtain desired result in an effective manner. There are various anesthetics that can be used to achieve regional or local anesthetic effect in this regard.

Aim: The aim of this study was to compare the efficacy of 2% lignocaine with 1:80,000 adrenaline, 0.

Role of Hematological and Immunological Parameters in COVID-19 Patients.

Background: The ongoing pandemic of coronavirus disease 2019 (COVID-19) which was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to efforts from the medical and scientific community in understanding the biological basis of COVID-19 pathophysiological mechanisms. Thus, analysis of various hematological and immunological parameters may be helpful for COVID-19 infection evaluation for risks involved and effectiveness in management.

Aim: The aim of this study was to analyze the role of various hematological and immunological parameters in patients infected with SARS-CoV-2.

mRNA Expression Analysis of E-Cadherin, VEGF, and MMPs in Gastric Cancer: a Pilot Study.

Gastric cancer (GC) is a serious fatal cancer on a global scale because of its presentation at advanced stage. The expressions of vascular endothelial growth factor (VEGF), E-cadherin, and matrix metalloproteinases (MMPs) in other cancers have been reported. However, its expression and underlying mechanisms are little known in gastric cancer in Indian context.

Impact of Oral Health Literacy on Periodontal Health among Low-income-group Workers of Dental Institutes in Patna, Bihar, India.

Aim: To evaluate the impact of oral health literacy (OHL) on the periodontal health among low-income-group workers of dental institutes.

Materials And Methods: A cross-sectional study was conducted on 137 class III and IV workers of dental college. Data collection was done by using a customized pro forma including demographics, REALD-30 for calculating OHL, and items on oral hygiene habits like toothpaste use, brushing frequency, and any other oral hygiene aid.

Determining the occlusal plane using hamular notch incisive papilla plane evaluator: An study.

Aims: Identification and establishment of the occlusal plane in patients with impaired occlusal plane, presents a major hurdle for the execution of natural esthetics, speech, and function. The aim of this study was to minimize such errors while occlusal rehabilitation, and employ hamular notchincisive papilla (H.I.

Optimization of phosphate recovery as struvite from synthetic distillery wastewater using a chemical equilibrium model.

This study investigates the feasibility of recovery of phosphorus via struvite precipitation from a synthetic anaerobically treated distillery spent wash by optimizing the process using a chemical equilibrium model, namely Visual MINTEQ. Process parameters such as Mg, [Formula: see text], and [Formula: see text] ion concentrations and pH were used as inputs into the model. Increasing the molar ratio of [Formula: see text] from 0.

OCT angiography features of paracentral acute middle maculopathy.

Paracentral acute middle maculopathy (PAMM) refers to retinal lesions with changes in the inner nuclear layer on spectral domain optical coherence tomography (OCT). PAMM is associated with retinal vascular pathology involving the deep capillary plexus. We report two cases of PAMM in Indian subjects using multimodal imaging highlighting the OCT angiography (OCTA) findings.