The quantity, reliability, transparency, reporting, and interpretation of pharmacovigilance signal detection studies in pregnancy: a meta-epidemiological study.

Purpose: To systematically review the characteristics of the available pharmacovigilance signal detection studies in pregnancy, and comprehensively assess the reliability, transparency, reporting, and interpretation of these studies.

Methods: We searched five databases from inception to February 2024 to identify the available pharmacovigilance signal detection studies in pregnancy. We extracted three aspects of information (basic information, data processing modes, signal detection analyses) to assess the reliability, transparency, and reporting of each study.

Nasal colonization of Staphylococcus aureus and the risk of surgical site infection after spine surgery: a meta-analysis.

Background Context: Nasal colonization of Staphylococcus aureus may increase the risk of surgical site infection (SSI) after spine surgeries, although the results of previous studies were inconsistent.

Purpose: To evaluate the influences of nasal colonization of S. aureus, methicillin-susceptible SA, and methicillin-resistant SA (MRSA) on the incidence of SSI after spine surgery.