microRNA-195 attenuates neuronal apoptosis in rats with ischemic stroke through inhibiting KLF5-mediated activation of the JNK signaling pathway.

Background: Accumulating evidence has implicated the regulation of microRNAs (miRs) in ischemia stroke. The current study aimed to elucidate the role of microRNA-195 (miR-195) in neuronal apoptosis and brain plasticity in rats with ischemic stroke via the JNK signaling pathway/KLF5 axis.

Methods: Ischemic stroke rat models were established by middle cerebral artery occlusion (MCAO), and oxygen deprivation (OGD) models were constructed in rat neuronal cells, followed by gain- or loss-of-function of miR-195 and/or KLF5 in rats and cells.

A new approach for an ultrasensitive tactile sensor covering an ultrawide pressure range based on the hierarchical pressure-peak effect.

Flexible tactile sensors that imitate the skin tactile system have attracted extensive research interest due to their potential applications in medical diagnosis, intelligent robots and so on. However, it is still a great challenge to date to fabricate tactile sensors with both high sensitivity and wide detection range due to the difficulties in modulating the resistance variation in the sensing materials in a wide pressure range. Here, a tactile sensor with a novel design based on the hierarchical pressure-peak effect (HPPE) consisting of PVP nanowires and electroless deposition (ELD) silver PDMS micro-pyramids is reported.

Effect of Heterointerface on NO Sensing Properties of In-Situ Formed TiO QDs-Decorated NiO Nanosheets.

In this work, TiO QDs-modified NiO nanosheets were employed to improve the room temperature NO sensing properties of NiO. The gas sensing studies showed that the response of nanocomposites with the optimal ratio to 60 ppm NO was nearly 10 times larger than that of bare NiO, exhibiting a potential application in gas sensing. Considering the commonly reported immature mechanism that the effective charge transfer between two phases contributes to an enhanced sensitivity, the QDs sensitization mechanism was further detailed by designing a series of contrast experiments.