Publications by authors named "Songqing Liu"
Thiamine and pyridoxine are essential B vitamins that serve as enzymatic cofactors in energy metabolism, protein and nucleic acid biosynthesis, and neurotransmitter production. In humans, thiamine transporters SLC19A2 and SLC19A3 primarily regulate cellular uptake of both vitamins. Genetic mutations in these transporters, which cause thiamine and pyridoxine deficiency, have been implicated in severe neurometabolic diseases.
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- The bZIP genes in Pseudoroegneria libanotica are key transcriptional coactivators in plants, helping them deal with stress, especially within the Triticeae tribe.
- A total of 108 bZIP genes have been identified, categorized into 10 subgroups, and they show different responses to stress factors like drought, salinity, heat, and heavy metals in both aerial and root tissues.
- Notably, PsebZIP44 and PsebZIP46 are highlighted as potential genes for improving stress tolerance, which could enhance the genetic makeup of Triticeae crops like wheat.
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- * Researchers analyzed data from the FDA Adverse Event Reporting System (FAERS) spanning from 2004 to 2022 to identify agents reported to trigger TLS and assess their associated risks through disproportionality analysis.
- * Results revealed that 164 antineoplastic agents were linked to TLS, with rituximab being the most frequently reported, while tagraxofusp showed the highest adverse reaction signal strength, indicating varying risks across different medications.
Background: The comprehensive quantitative and comparative risk data of drug-induced erectile dysfunction (ED) are still lacking, and this study aims to supplement this information.
Research Design And Methods: We reviewed all the ED reports in the FDA Adverse Event Reporting System (FAERS) database from 2004 to 2023 and summarized a potential ED culprit-drug list and its corresponding reporting frequency. The reporting odds ratio (ROR) method was used to conduct disproportionality analysis.
Article Synopsis
- * Researchers created chromosome painting probes for the St genome of Pseudoroegneria, enabling identification of its chromosomes and revealing the conservation of St chromosomes across several plant genera.
- * Findings indicate that the Y genome originated from the St genome, suggesting evolutionary links among Roegneria and Campeiostachys species and highlighting the morphological differences and similarities among awnless and awned species.
Background: At present, drug development for treating Alzheimer's disease (AD) is still highly challenging. Eriodictyol (ERD) has shown great potential in treating AD, but its molecular mechanism is unknown.
Objective: We aimed to explore the potential targets and mechanisms of ERD in the treatment of AD through network pharmacology, molecular docking, and molecular dynamics simulations.
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- The lateral organ boundaries domain (LBD) is crucial in plant growth, development, and stress response, and previous research indicated its role in drought resistance in Pseudoroegneria libanotica, a key plant in studying stress mechanisms in Triticeae species.
- In this study, 29 PseLBD genes were identified, primarily classified into subclass I, with evidence suggesting extensive involvement in biological processes and a significant single whole-genome duplication event.
- Key candidates for drought stress response, PseLBD1 and PseLBD12, demonstrated abilities to withstand various stressors in yeast, highlighting their potential for enhancing crop genetics in Triticeae species like wheat.
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- Doxorubicin (DOX) is an effective cancer drug, but its use is limited due to cardiotoxicity (DIC), while eriodictyol (ERD) shows promise in providing heart protection against this side effect.
- This study investigates how ERD protects the heart by analyzing ERD and DIC-targets through various biological databases and conducting network pharmacology and molecular docking analyses.
- Results indicate that ERD interacts with 43 targets related to DIC, with strong binding to key targets and involvement in the ROS pathway, suggesting a multi-targeted cardioprotective effect.
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- Xiaochaihu (XCH) decoction is a traditional Chinese medicine used in China to treat various tumors, including breast cancer, but its specific mechanisms are not fully understood.
- The study identified over 70 compounds in the XCH decoction and constructed a network linking 162 active ingredients to 153 targets related to breast cancer, highlighting its effects on drug response and cancer pathways through advanced analysis techniques.
- Findings indicated that XCH decoction may inhibit breast cancer cell growth and promote cell death by regulating apoptosis-related proteins and suppressing the PI3K/Akt signaling pathway.
Soil cadmium (Cd) contamination is an urgent environmental problem, which endangers human health through the food chain. Bioremediation attracted extensive attention around the world due to the high cost-efficiency. However, the remediation efficiency of different plant and earthworm species of soil Cd pollution is still unclear, it is thus of great significance to explore the combined effects of different remediation plants and earthworm species to improve the bioremediation capacity.
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- Defense-associated sirtuin 2 (DSR2) systems in prokaryotes help protect against phage infections by targeting phage tail tube proteins and reducing intracellular NAD, leading to abortive infections.
- The study reveals cryo-EM structures of DSR2 in different states, showing it forms a tetramer with enzymatic modules and highlights how the monomeric Tube protein binds to DSR2 to activate its function.
- DSR Anti Defense 1 (DSAD1) inhibits DSR2 by competing for the same binding site as the Tube protein, thus providing a mechanism for phages to counteract bacterial defenses.
Mastitis is a disease characterized by congestion, swelling, and inflammation of the mammary gland and usually caused by infection with pathogenic microorganisms. Furthermore, the development of mastitis is closely linked to the exogenous pathway of the gastrointestinal tract. However, the regulatory mechanisms governing the gut-metabolism-mammary axis remain incompletely understood.
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- Liujunzi Decoction (LJZD) is being investigated as a treatment for breast cancer, but its active ingredients and how they work are not yet fully understood.
- The study utilized network pharmacology and molecular docking to identify the target genes and mechanisms of LJZD in combating breast cancer.
- Key findings included 126 active ingredients, 241 breast cancer-related targets, and 180 intersecting targets, with core targets identified as FOS and ESR1, and involved signaling pathways like PI3K/Akt and MAPK.
The dysregulation of sex hormone levels is associated with metabolic disorders such as obesity. Inonotus obliquus polysaccharide (IOP) exhibits a promising therapeutic effect on conditions like obesity and diabetes, potentially linked to its influence on intestinal microbiota and metabolism. The exact cause and mechanisms that link sex hormones, gut microbiota and metabolism are still unknown.
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- Drug-induced QT prolongation and Torsade de Pointes (TdP) are serious adverse reactions caused by several medications, but there's a lack of comprehensive data on the specific drugs responsible.
- A review of the FDA Adverse Event Reporting System from 2004 to 2022 identified 42,713 reports linked to QT prolongation and TdP, highlighting furosemide as the most frequently reported drug, primarily among antineoplastics.
- The analysis revealed 612 drugs with positive adverse drug reaction signals, indicating significant variability in risk levels among different drug classes, such as psycholeptics and beta-blockers.
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- Timely recognition and stoppage of drugs causing acute pancreatitis (AP) is crucial for treatment, but information on these drugs is limited.
- An analysis of FDA adverse event reports from 2004 to 2022 identified 1,175 drugs linked to AP, with metformin having the most reports, followed by quetiapine and others, mainly from diabetes medications.
- The study found that 595 drugs showed a potential risk for AP, with antineoplastic agents having the most positive signals, providing valuable insights for clinical practice regarding drug safety.
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- The study investigates the effects of a polysaccharide (IOP) on the intestinal flora of male and female rats, focusing on structural changes and microbial diversity.
- Using advanced techniques like HPGPC and NMR, researchers confirmed IOP's high purity and identified its chemical structure as a linear macromolecule.
- Results showed that IOP increased beneficial bacteria in both genders while altering sex hormone levels, with more significant changes in microbial diversity seen in male rats compared to females.
Cadmium (Cd) is a toxic element that can negatively affect both humans and animals. It enters the human and animal bodies through the respiratory and digestive tracts, following which it tends to accumulate in different organs, thereby seriously affecting human and animal health, as well as hampering social and economic development. Cd exposure can alter the composition of intestinal microbiota.
View Article and Find Full Text PDFChromosome-specific painting probes were developed to identify the individual chromosomes from 1 to 7E in Thinopyrum species and detect alien genetic material of the E genome in a wheat background. The E genome of Thinopyrum is closely related to the ABD genome of wheat (Triticum aestivum L.) and harbors genes conferring beneficial traits to wheat, including high yield, disease resistance, and unique end-use quality.
View Article and Find Full Text PDFEnvironmental exposure to hazardous materials causes enormous socioeconomic problems due to its deleterious impacts on human beings, agriculture and animal husbandry. As an important hazardous material, cadmium can promote uterine oxidative stress and inflammation, leading to reproductive toxicity. Antioxidants have been reported to attenuate the reproductive toxicity associated with cadmium exposure.
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- * A total of 8,063 CDI cases linked to 73 antibacterial drugs were analyzed, with metronidazole showing the highest number of reports and positive adverse reaction signals.
- * The findings suggest that the CDI risk associated with metronidazole and vancomycin may be underestimated and warrant further investigation.
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- The text refers to a correction made to a previously published article identified by its DOI: 10.3389/fcimb.2021.791373.
- This correction is likely addressing errors or inaccuracies in the original article's content.
- Having the DOI allows readers to easily locate both the original article and the corrected version.
Article Synopsis
- - The study aims to identify drugs that cause severe cutaneous adverse reactions (SCARs) by analyzing data from the FDA Adverse Event Reporting System from 2004 to 2021, providing valuable information for clinical practice.
- - A total of 77,789 SCAR-related reports were analyzed, revealing that lamotrigine, acetaminophen, and allopurinol were among the most frequently reported drugs, with antibacterials being the most common drug class associated with SCARs.
- - The research identified 1,219 drugs linked to SCARs, with disproportionality analysis highlighting 776 drugs with positive pharmacovigilance signals, thus offering insights into the risk characteristics of SCARs for
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- * In a study comparing two groups of MDRO patients, those receiving early pharmacist consultation (PEAC) experienced a 70% reduction in 30-day mortality and better clinical improvement than those who did not receive this consultation.
- * Despite the positive effects on mortality and clinical outcomes, there were no notable differences in hospital stay length, antibiotic usage, or costs between the two patient groups.
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- The guidelines for preventing and managing perioperative infection in China have been updated to address global antimicrobial resistance issues and improve infection control practices in hospitals.
- A comprehensive evaluation was conducted using the GRADE system, involving feedback from experts via the Delphi method, leading to 37 recommendations based on 17 key questions.
- The revised guidelines aim to enhance the rational use of antimicrobial prophylaxis, improving outcomes related to the risk-benefit balance for patients undergoing surgery.