SENP3 inhibition suppresses hepatocellular carcinoma progression and improves the efficacy of anti-PD-1 immunotherapy.

The importance of SUMOylation in tumorigenesis has received increasing attention, and research on therapeutic agents targeting this pathway has progressed. However, the potential function of SUMOylation during hepatocellular carcinoma (HCC) progression and the underlying molecular mechanisms remain unclear. Here, we identified that SUMO-Specific Peptidase 3 (SENP3) was upregulated in HCC tissues and correlated with a poor prognosis.

Facile fabrication of a thermal/pH responsive IPN hydrogel drug carrier based on cellulose and chitosan through simultaneous dual-click strategy.

Herein, an interpenetrating network hydrogel (IPN-Gel) based on cellulose and chitosan was synthesized via simultaneous amino-anhydride and azide-alkyne click reaction in water in one pot. The samples were characterized by various analytical methods including FTIR, SEM, XRD, XPS, H NMR and so forth. The fabrication conditions were optimized by single factor experiments with water uptake (WU) and gel mass fraction (GMF) as two indexes.

Facile fabrication of semi-IPN hydrogel adsorbent based on quaternary cellulose via amino-anhydride click reaction in water.

Clean and safe water resources play a key role in environmental safety and human health. Recently, hydrogels have attracted extensive attention due to their non-toxicity, controllable performance, and high adsorption. Herein, a semi- interpenetrating network hydrogel (semi-IPN-Gel) adsorbent based on quaternary cellulose (QC) was prepared by the amino-anhydride click reaction between maleic anhydride copolymer and polyacrylamine hydrochloride (PAH), and its adsorption properties for Eosin Y were studied.

Preparation and characterization of starch-cellulose interpenetrating network hydrogels based on sequential Diels-Alder click reaction and photopolymerization.

Herein, starch-cellulose interpenetrating network (IPN) hydrogels were fabricated by sequential Diels-Alder click reaction and photopolymerization in water. Moreover, β-cyclodextrin, a commonly used host molecule in supramolecular chemistry, was also introduced to improve the performance of the IPN hydrogel. Firstly, the starch-based dienes were synthesized by modifying starch with N-maleoyl-β-alanine, and the cellulose-based dienophiles were obtained by the reaction of cellulose and furfurylamide succinate; Secondly, the as-synthesized starch-based dienes, cellulose-based dienophiles, polymerizable β-cyclodextrin, crosslinker, and acrylamide were dissolved in water and obtained a transparent solution.

Characterization of biofuel production from hydrothermal treatment of hyperaccumulator waste ( L.) in sub- and supercritical water.

In this study, hyperaccumulator waste, , L. was converted into bio-oil, biogas and biochar sub- and supercritical hydrothermal liquefaction processes. These products were characterized in terms of EI/MS, FTIR, TGA and GC to understand their chemical composition, thermal decomposition, structural properties and high biofuel reactivity.