Assessing HIV/AIDS patients' access to antiretroviral drugs using the healthcare accessibility framework: a cross-sectional study from Shandong, China.

Background: Antiretroviral drugs are important for HIV/AIDS patients, but we know little about the real-life barriers patients face in accessing them. Following the Levesque framework, this study described the five abilities of HIV/AIDS patients in Shandong Province to perceive, to seek, to reach, to pay and to engage in accessing antiretroviral drugs and the factors associated with them.

Methods: A cross-sectional questionnaire survey, using convenience sampling, was conducted among HIV/AIDS patients in three AIDS-designated hospitals in Shandong Province.

Ultrasonic-Assisted Electrodeposition of Cu-TiO Nanocomposite Coatings with Long-Term Antibacterial Activity.

Bacterial adhesion, colonization, and spread on aluminum alloy surfaces pose significant risks to human health and public safety. To address these issues, this investigation employed an ultrasonic-assisted electrodeposition method to synthesize long-lasting antibacterial Cu-TiO nanocomposite coatings on porous anodized aluminum oxide (AAO) substrates. Leveraging the cavitation effect of ultrasound, this approach fostered the dispersive incorporation of TiO nanoparticles into the resulting composite coating, thereby expediting the crystallization process of electrodeposition and refining the granular structure.

Nickel/Photoredox Dual-Catalyzed Regiodivergent Aminoalkylation of Unactivated Alkyl Halides.

A mild and regiodivergent aminoalkylation of unactivated alkyl halides is disclosed via a dual photoredox/nickel catalysis. Bipyridyl-type ligands without an -substituent control the site-selective coupling at the original position, while -disubstituted ligands tune the site-selectivity at a remote, unprefunctionalized position. Mechanistic studies combined with DFT calculations give insight into the mechanism and the origins of the ligand-controlled regioselectivity.

α-Tertiary Primary Amine Synthesis via Photocatalytic C(sp)-H Aminoalkylation.

Facile access to sterically hindered α-tertiary primary amines via photocatalytic radical coupling of native C(sp)-H substrates with -unsubstituted ketimines is reported. LiBr was used as a hydrogen atom transfer reagent to cleave C(sp)-H bonds to get alkyl radicals. The in situ-generated HBr can then serve as a Bronsted acid to activate -unsubstituted ketimines readily for single-electron reduction to deliver α-amino radicals.

Remote and Proximal Hydroaminoalkylation of Alkenes Enabled by Photoredox/Nickel Dual Catalysis.

A mild and site-selective hydroaminoalkylation of activated and unactivated alkenes via dual photoredox/Ni catalysis is developed. This dual catalytic strategy enables exclusive access to α-selective products, which is complementary to previously reported photocatalytic hydroaminoalkylation of activated alkenes that provides the β-selective products. The chain-walking of a Ni-H intermediate toward a carbonyl allows for the hydroaminoalkylation of unactivated alkenes at remote C-H sites.

From Esters to Ketones via a Photoredox-Assisted Reductive Acyl Cross-Coupling Strategy.

A method was developed for ketone synthesis via a photoredox-assisted reductive acyl cross-coupling (PARAC) using a nickel/photoredox dual-catalyzed cross-electrophile coupling of two different carboxylic acid esters. A variety of aryl, 1°, 2°, 3°-alkyl 2-pyridyl esters can act as acyl electrophiles while N-(acyloxy)phthalimides (NHPI esters) act as 1°, 2°, 3°-radical precursors. Our PARAC strategy provides an alternative and reliable way to synthesize various sterically congested 3°-3°, 3°-2°, and aryl-3° ketones under mild and highly unified conditions, which have been otherwise difficult to access.

Dataset for verification of a vibro-acoustic coupling model and optimized results on sectional geometries of two sealing rubber models.

This data article comprises collected data to verify a vibro-acoustic coupling model and raw records of optimized results on sectional geometries of two simplified sealing rubber models. The dataset is generated based on both analytical methods and numerical solutions, including Finite Element Simulation and Hybrid Finite Element - Statistic Energy Analysis Simulation. The calculations have been performed through a 2.

Selective 1,2-Aryl-Aminoalkylation of Alkenes Enabled by Metallaphotoredox Catalysis.

A highly chemo- and regioselective intermolecular 1,2-aryl-aminoalkylation of alkenes by photoredox/nickel dual catalysis is described here. This three-component conjunctive cross-coupling is highlighted by its first application of primary alkyl radicals, which were not compatible in previous reports. The readily prepared α-silyl amines could be transferred to α-amino radicals by photo-induced single electron transfer step.

Predicting the Tensile Behavior of Ti-6.6Al-3.3Mo-1.8Zr-0.29Si Alloy via the Temperature-Dependent Crystal Plasticity Method.

Uniaxial tensile flow properties of a duplex Ti-6.6Al-3.3Mo-1.

Karyotype evolution in .

The germ tube burst method (GTBM) was employed to examine karyotypes of 33 species representative of 11 species complexes that span the phylogenetic breadth of the genus. The karyotypes revealed that the nucleolar organizing region (NOR), which includes the ribosomal rDNA region, was telomeric in the species where it was discernible. Variable karyotypes were detected in eight species due to variation in numbers of putative core and/or supernumerary chromosomes.