Quantitative proteomics analysis reveals the pathogenesis of obstructed defecation syndrome caused by abnormal expression of dystrophin.

Background: Obstructed defecation syndrome (ODS) represents the most prevalent form of chronic constipation, affecting a diverse patient population, leading to numerous complications, and imposing a significant burden on healthcare resources. Most ODS patients have insufficient rectal propulsion, but the exact mechanism underlying the pathogenesis of ODS remains unclear.

Aim: To explore the molecular mechanism underlying the pathogenesis of ODS.

Development of Pseudosacral Cyst Following Surgery for Primary Presacral Neuroendocrine Tumors With Liver Metastasis: A Case Report.

Presacral neuroendocrine tumor (PSNET) is a rare disease that currently lacks a standardized treatment approach. In this report, we present a unique case of PSNET with liver metastasis that progressed into a pseudosacral cyst following complete surgical resection and sulfatinib treatment with radiofrequency ablation. Before undergoing surgical treatment for presacral neuroendocrinology, it is important to consider the potential risks of poor healing of the presacral incision and formation of pseudocysts.

Data-based systematic error extraction and compensation methods based on wavelet transform in ultra-precision optical polishing.

Sub-aperture polishing is a key technique for fabricating ultra-precision optics. However, the existence of the polishing errors that are difficult to be compensated by physical modeling seriously affects the manufacturing accuracy and efficiency of optical components. To address this problem, a data-based systematic error extraction and compensation (DSEC) method was proposed to enhance the polishing accuracy on optics.

Evolution mechanism of subsurface damage during laser machining process of fused silica.

The machining-induced subsurface damage (SSD) on fused silica optics would incur damage when irradiated by intense lasers, which severely restricts the service life of fused silica optics. The high absorption of fused silica to 10.6 µm makes it possible to utilize pulsed CO laser to remove and characterize SSD by layer-by-layer ablation, which improves its laser-induced damage threshold.

Plug-and-play positioning error compensation model for ripple suppressing in industrial robot polishing.

The industrial robot-based polisher has wide applications in the field of optical manufacturing due to the advantages of low cost, high degrees of freedom, and high dynamic performance. However, the large positioning error of the industrial robot can lead to surface ripple and seriously restrict the system performance, but this error can only be inefficiently compensated for by measurement before each processing at present. To address this problem, we discovered the period-phase evolution law of the positioning error and established a double sine function compensation model.

Theoretical and experimental investigations in thermo-mechanical properties of fused silica with pulsed CO laser ablation.

Laser ablation is widely used as a flexible and non-contact processing technology for the fabrication of fused silica. However, the introduction of thermal stress inevitably leads to crack growth and reduces the lifetime of fused silica. Due to the complicated coupling interaction and properties of fused silica, the unclear thermal stress formation is the bottleneck restricting further development of laser ablation.

Retroperitoneal abscess as a presentation of colon cancer: The largest case set analysis to date, which extracted from our unit and the literature.

Objective: Colon cancer with retroperitoneal abscess is a rare and easily misdiagnosed disease and has only been reported via case. There is an urgent need to conduct a dataset analysis for such patients, which is crucial to improving the survival rate and quality of life of these patients.

Methods: Patients with colon cancer associated with retroperitoneal abscess were extracted from our hospital and the PubMed, EMBASE and Web of Science databases.

Densi-melting effect for ultra-precision laser beam figuring with clustered overlapping technology at full-spatial-frequency.

Laser beam figuring (LBF), as a processing technology for ultra-precision figuring, is expected to be a key technology for further improving optics performance. To the best of our knowledge, we firstly demonstrated CO LBF for full-spatial-frequency error convergence at negligible stress. We found that controlling the subsidence and surface smoothing caused by material densification and melt under specific parameters range is an effective way to ensure both form error and roughness.

Modeling and in-depth analysis of the mid-spatial-frequency error influenced by actual contact pressure distribution in sub-aperture polishing.

In ultra-precision optical processing, the sub-aperture polishing is prone to produce a mid-spatial-frequency (MSF) error. However, the generation mechanism of the MSF error is still not fully clarified, which seriously affects the further improvement of optical component performance. In this paper, it is proved that the actual contact pressure distribution between the workpiece and tool is a crucial source which affects the MSF error characteristics.

Fourier convolution-parallel neural network framework with library matching for multi-tool processing decision-making in optical fabrication.

Intelligent manufacturing of ultra-precision optical surfaces is urgently desired but rather difficult to achieve due to the complex physical interactions involved. The development of data-oriented neural networks provides a new pathway, but existing networks cannot be adapted for optical fabrication with a high number of feature dimensions and a small specific dataset. In this Letter, for the first time to the best of our knowledge, a novel Fourier convolution-parallel neural network (FCPNN) framework with library matching was proposed to realize multi-tool processing decision-making, including basically all combination processing parameters (tool size and material, slurry type and removal rate).

Pan-cancer analysis confirms the prognostic and immunological effects of prostate tumor overexpressed-1 in human cancers.

Background: Prostate tumor overexpressed-1 (PTOV1) is a conserved oncogenic adaptor protein associated with cancer progression and may be an independent prognostic marker for several malignancies. Consequently, using pan-cancer research to explore the significance of PTOV1 is valuable, and may reveal novel targets for cancer treatment.

Methods: A comprehensive bioinformatics analysis of PTOV1 was performed.

Statistical perception of the chaotic fabrication error and the self-adaptive processing decision in ultra-precision optical polishing.

Subaperture polishing is a key technique for fabricating ultra-precision optics. However, the error source complexity in the polishing process creates large fabrication errors with chaotic characteristics that are difficult to predict using physical modelling. In this study, we first proved that the chaotic error is statistically predictable and developed a statistical chaotic-error perception (SCP) model.

Down regulation of NDUFS1 is involved in the progression of parenteral-nutrition-associated liver disease by increasing Oxidative stress.

Parenteral nutrition (PN)-associated liver disease (PNALD) is a common and life-threatening complication of patients receiving PN. However, its definitive pathology remains unclear. Ubiquinone oxidoreductase core subunit S1 (NDUFS1), which is the largest core subunit of mitochondrial complex I, could alter the mitochondrial reactive oxygen species (ROS) formation.

Liver PP2A-Cα Protects From Parenteral Nutrition-associated Hepatic Steatosis.

Background & Aims: Parenteral nutrition (PN) is a lifesaving therapy for patients with intestinal failure. Hepatic steatosis is a potentially fatal complication of long-term PN, but the involved pathological mechanisms are incompletely unclarified. Herein, we identify the role of protein phosphatase 2A (PP2A) in the pathogenesis of parenteral nutrition-associated hepatic steatosis (PNAHS).

Iterative space-variant sphere-model deflectometry enabling designation-model-free measurement of the freeform surface.

Freeform optics, offering high degrees of design freeform to control light propagation, have already been widely applied in various photoelectric equipment. The form quality of those optics is crucial to their opto-electronics functionalities, which requires to be measured accurately. The deflectometry is a promising technology to test the complex freeform surfaces.

Sparse bi-step raster path for suppressing the mid-spatial-frequency error by fluid jet polishing.

The periodic ripple errors (mid-spatial-frequency (MSF) error) produced by computer-controlled sub-aperture polishing severely limit the improvement of high-performance optical systems. At the same time, the fluid jet polishing (FJP) method is non-destructive and non-contact, but it is still hard to widely use it due to the defect of small spot-size and low efficiency. In this paper, we found that FJP has a significant advantage in removing the residual periodic ripples in sub-aperture polishing.

Modeling and prediction of tool influence function under complex edge in sub-aperture optical polishing.

Edge mis-figures are regarded as one of the most difficult technical issues in optical fabrication. At present, only the near straight-line edge tool influence function (TIF) can be fitted by a polynomial function, but it is difficult to unify a 2-D analytical model suitable for complex edge workpieces and various tools, due to the lack of the scientific understanding of the edge removal behavior. In this paper, a comprehensive mathematical model is proposed to reveal the mechanism of the edge effect and accurately predict the complex edge TIF.

High-efficiency smooth pseudo-random path planning for restraining the path ripple of robotic polishing.

Computer-controlled subaperture polishing technology is limited by its propensity to introduce midspatial frequency (MSF) error (ripple error), which significantly inhibits the performance improvement of optical systems. The pseudo-random polishing path is an important method for suppressing MSF error. However, a pseudo-random path that ensures both path smoothness and planning efficiency is difficult to generate.

Iron overload is related to muscle wasting in patients with cachexia of gastric cancer: using quantitative proteome analysis.

The incidence of gastric cancer cachexia is high and the clinical management is poor, so the study aimed to clarify the mechanism of muscle wasting to better screen patients with gastric cancer cachexia. Gastric cancer patients undergoing radical gastrectomy were divided into cachexia with sarcopenia (CS, n = 13) and normal (N, n = 10) two groups. The possible mechanism of skeletal muscle reduction was explored through Tandem Mass Tag (TMT) technique, Perls staining, Western blot analysis and measurement of oxidative stress indicators.

Nonthyroidal Illness Syndrome in Patients With Short-Bowel Syndrome.

Background: Nonthyroidal illness syndrome (NTIS) is prevalent in critical illness and is associated with poor outcomes. However, only few studies have focused on the relationship between NTIS and short-bowel syndrome (SBS). The aim of this study was to investigate the prevalence, etiology, and prognosis of NTIS and its correlation with clinical variables in adult patients with SBS.

Autophagy suppression plays a role in parenteral nutrition-associated lung injury.

Background & Aims: The long-term usage of parenteral nutrition (PN) is associated with the increased incidence of pneumonia. Few studies have focused on the pathogenesis of PN-associated lung injury (PNLI). Previous studies have found that autophagy suppression may be an important mechanism for PN-associated complications.

Differential Metabolomic Analysis of Liver Tissues from Rat Models of Parenteral Nutrition-Associated Liver Disease.

Parenteral nutrition (PN) is a life-saving therapy for patients with intestinal failure, but parenteral nutrition-associated liver disease (PNALD) limits its long-term use. The present study is aimed at determining which pathways are altered most notably in a rat model of PNALD. We randomly assigned male Sprague-Dawley (SD) rats into two different groups, whereby they received either enteral nutrition (EN) or PN.

Modeling and analysis of the mid-spatial- frequency error characteristics and generation mechanism in sub-aperture optical polishing.

In the field of ultra-precision manufacturing, the mid-spatial-frequency (MSF) error can severely affect the performance of the optical elements, but it is rather difficult to quantitatively predict the MSF error distribution. In this paper, the piecewise-path convolution (PPC) analysis is established to investigate the characteristic and the mechanism of the MSF error. The path type, tool influence function (TIF), feed rate, movement type, etc.

Superior Mesenteric Artery Syndrome Improved by Enteral Nutritional Therapy: A Retrospective Case-Series Study in a Single Institution.

Introduction: Superior mesenteric artery syndrome (SMAS) is a relatively rare cause of chronic duodenal obstruction, owing to the compression of the third portion of the duodenum.

Objectives: This retrospective study aims to discuss the efficacy of enteral nutrition (EN) therapy in nutritional status and symptom improvement at a short-term follow-up for SMAS patients.

Methods: We retrospectively analyzed clinical data of patients diagnosed as SMAS and treated with EN from September 2012 to January 2019.

Prolonged Parenteral Nutrition Is One of the Most Significant Risk Factors for Nosocomial Infections in Adult Patients With Intestinal Failure.

Background: Intestinal failure (IF) and its management are associated with an increased likelihood of infectious complications. This study aimed to evaluate the prevalence and potential risk factors for nosocomial infections (NIs) in hospitalized adult patients with IF.

Methods: In total, 259 eligible patients with IF admitted to a single clinical nutrition center in a tertiary referral hospital from January 1, 2012, to January 1, 2019, were retrospectively identified.