The prognostic value of MELD-XI in elderly patients with ST-segment elevation myocardial infarction: an observational study.

Background: The model for end-stage liver disease excluding international normalized ratio (MELD-XI) is a simple score for risk assessment. However, the prognostic role of MELD-XI and its additional value to current risk assessment in elderly patients with ST-segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI) is uncertain.

Methods: In all, 1029 elderly patients with STEMI undergoing PCI were consecutively included and classified into three groups according to the TIMI risk score: low-risk (≤ 3, n = 251); moderate-risk (4-6, n = 509); and high-risk (≥ 7, n = 269) groups.

Role of statins in preventing cardiac surgery-associated acute kidney injury: an updated meta-analysis of randomized controlled trials.

Background: The prevention of cardiac surgery-associated acute kidney injury (CSA-AKI) by statins remains controversial. Therefore, the present meta-analysis including randomized controlled trials (RCTs) was performed to assess the effect of perioperative statin on CSA-AKI.

Methods: Two reviewers independently searched for RCTs about perioperative statin for prevention of CSA-AKI.

Inhibition of miR-186-5p contributes to high glucose-induced injury in AC16 cardiomyocytes.

A growing body of evidence has demonstrated that microRNAs (miRs) have pivotal roles in the pathophysiological development mechanisms of diabetic cardiomyopathy (DCM). Previous studies have demonstrated that miR-186-5p was significantly decreased in DCM. In addition, it has recently been reported that an imbalance of miR-186 is associated with a variety of physiological and pathological processes.

New mechanism of lipotoxicity in diabetic cardiomyopathy: Deficiency of Endogenous HS Production and ER stress.

Objective: To investigate the roles and mechanisms of endogenous hydrogen sulfide (HS) and endoplasmic reticulum (ER) stress in the development of diabetic cardiomyopathy (DCM).

Methods: Blood of DCM patients included in the study were collected. The model of DCM rats was established using streptozotocin (STZ) injection.

Angiographic and interventional management for a esophagopericardial fistula.

We reported a case of a 78-year-old patient with esophagopericardial fistula who was referred for angiographic and interventional management. Emergent implantation of the esophageal stent could not lengthen or even save the patient's life. One week later, the patient died of multiple organ failure, which was probably from formation of granulation tissue and stent migration.