Publications by authors named "Songhomitra Panda-Jonas"
Purpose: To examine intraretinally migrated retinal pigment epithelium cells (iRPECs) in enucleated human eyes with various retinal conditions and corresponding intraretinal hyperreflective bodies (iHRBs) in a large cohort of patients with age-related macular degeneration (AMD) in China.
Design: Population-based study and histomorphometric investigation.
Participants: Participants of the population-based Beijing Eye Study and enucleated human eyes.
Article Synopsis
- The review summarizes the clinical and anatomical aspects of myopia, highlighting the different stages of myopic maculopathy (MMP) and their association with retinal changes.
- Recent findings show that MMP stage-4 is linked to defects in Bruch's membrane and previous macular neovascularization, while stage-3 demonstrates differences based on the presence of these defects.
- Additionally, higher axial lengths in myopic eyes correlate with increased risks for vision loss and certain eye conditions, including open-angle glaucoma, emphasizing the complexity and implications of myopia in aging populations.
Prevalence and associations of dome-shaped maculas. The Beijing Eye Study.
Acta Ophthalmol
September 2024
Article Synopsis
- The study investigates the occurrence of dome-shaped maculas (DSMs) in a diverse population, focusing on those with different axial lengths of the eye.
- Out of 3468 participants, DSMs were found in 1.9% of examined eyes, with a notable increase in prevalence among highly myopic individuals (7.2%).
- Results suggest that longer axial lengths and more advanced myopic macular degeneration are linked to higher DSM prevalence and height, indicating potential underlying factors related to eye elongation and retinal health.
Article Synopsis
- The study investigates the occurrence and factors related to parapapillary scleral ridges (PSRs) in a population from the Beijing Eye Study, specifically focusing on individuals with different axial lengths of the eye.
- Results show that PSR prevalence significantly increases with higher myopia, from 0% in non-myopic to 29.2% in highly myopic individuals, with age, female sex, and longer axial length being correlated factors.
- The findings suggest that PSRs are common in highly myopic eyes, and their presence may result from biomechanical interactions involving the optic nerve and elongated eye structures.
Purpose: To assess the prevalence of age-related macular degeneration (AMD) and reticular pseudodrusen (RPD) in very old individuals.
Methods: The population-based Ural Very Old Study consisted of 1526 (81.1%) out of 1882 eligible individuals aged 85 + years.
Purpose: To explore prevalence and associated factors of abnormalities of the posterior eye shape in dependence of axial length.
Design: Population-based study.
Participants: Of the participants (n = 3468) of the Beijing Eye Study, we included all eyes with an axial length of ≥25 mm, and a randomized sample of eyes with an axial length of <25 mm.
The purpose of the experimental interventional study was to examine the influence of intraocularly applied amphiregulin, a member of the epidermal growth factor (EGF) family, on axial length in young non-human primates. It included three non-human primates (Macaca mulatta), aged 4-6 years. The left eyes received three intravitreal injections of amphiregulin (400ng/50 μl) in intervals of 4 weeks, while the right eyes received three intravitreal injections of phosphate buffered solution (50 μl) at the same time points.
View Article and Find Full Text PDFPurpose: To assess prevalence of cataract and cataract surgery in a very old population in Russia.
Design: Population-based study.
Participants: The Ural Very Old Study included 1526 (81.
Prcis: A large disk, a large parapapillary delta zone and a long axial length may be used as screening criteria to detect glaucomatous optic neuropathy in highly myopic eyes.
Purpose: To describe aspects for screening of glaucomatous optic neuropathy in dependence of refractive error, under special consideration of high myopia.
Methods/results: Studies on the anatomy of the myopic optic nerve head and results of investigations on the relationship between glaucomatous optic neuropathy and axial myopia were included.
Myopic Macular Atrophy in the Two-Continent Population-Based Study.
Invest Ophthalmol Vis Sci
July 2024
Purpose: To examine the prevalence of Bruch's membrane defects (BMDs) and subretinal proliferations (SRPs) in highly myopic eyes with myopic macular atrophy (myopic macular degeneration [MMD] stage 4) and myopic patchy atrophies (MMD stage 3) in three ethnically different cohorts recruited in a population-based manner.
Methods: The Ural Eye and Medical Study (UEMS) and Beijing Eye Study (BES) included individuals aged 40+ years, and the Ural Very Old Study (UVOS) examined individuals aged 85+ years. Main outcome measures were the prevalence of BMDs and SRPs.
Purpose: Prevalence of myopia and vision impairment due to myopic macular degeneration and myopia-related optic neuropathies have markedly increased worldwide. We evaluated whether myopia is associated with other ocular disorders.
Design: Population-based studies conducted in Russia, China, and India.
Purpose: To assess associations between atrial fibrillation/atrial flutter (AF) and ocular parameters and diseases.
Methods: The population-based Ural Eye and Medical Study (UEMS) and the Ural Very Old Study (UVOS) included 4894 individuals (age: 40+ years) and 835 individuals (age: 85+ years), respectively.
Results: In the UEMS, AF prevalence (80/4894; 1.
Background: To explore the prevalence of self-reported unintentional injuries and falls (UIFs) in medium-aged and old populations in Russia and factors associated with them.
Methods: Two population-based studies (Ural Eye and Medical Study (UEMS), Ural Very Old Study (UVOS)) were carried out urban and rural areas in Bashkortostan/Russia. They consisted of 5899 individuals (age: 40+ years) and 1526 participants (age: 85+ years), respectively.
Purpose: To assess the prevalence of myopic macular degeneration (MMD) in very old individuals.
Methods: The population-based Ural Very Old Study (UVOS) included 1526 (81.1%) of 1882 eligible inhabitants aged ≥85 years.
Purpose: To examine histological characteristics and differences between drusen beneath the retinal pigment epithelium (small hard drusen) located in the macula and located in the parapapillary region.
Methods: We histomorphometrically examined human eyes enucleated due to uveal melanomas or secondary angle-closure glaucoma.
Results: The study included 106 eyes (age, 62.
Purpose: To explore intraocular pressure (IOP) and its associated parameters in an aged population.
Methods: The epidemiologic Ural Very Old Study (UVOS) conducted in Bashkortostan/Russia included 1526 participants with an age of ≥85 years. Besides a whole series of ocular and systemic examinations, IOP was determined applying non-contact tonometry.
Purpose: To examine Bruch's membrane (BM) in association with the longitudinal part of the ciliary muscle (LPCM) in the pars plana region.
Methods: Using light microscopy, we histomorphometrically assessed BM and the LPCM in the pars plana region.
Results: The histomorphometric study included 51 eyes (51 patients; mean age: 60.
Article Synopsis
- - The study examined the link between chronic kidney disease (CKD) and age-related macular degeneration (AMD) using data from over 51,000 participants across ten Asian studies, aiming to clarify previous mixed findings on this relationship.
- - Results showed that individuals with CKD had a 46% higher odds of developing late AMD compared to those without, and worse kidney function correlated with increased risk of late AMD, but no significant association was found for early AMD.
- - The findings suggest that while CKD and reduced kidney function are significantly associated with late AMD, early AMD does not appear to have a similar connection, highlighting the importance of monitoring kidney health in aging populations.
Purpose: To estimate prevalence and associations of keratoconus in populations in Russia with an age from childhood to seniority.
Methods: The study population consisted of the cohorts of 3 population-based studies performed in urban and rural areas within the same geographical region in Bashkortostan/Russia: the Ural Children Eye Study (UCES; age = 6-18 y; n = 4890), the Ural Eye and Medical Study (UEMS; age = >40 y; n = 5314), and the Ural Very Old Study (UVOS; age = >85 y; n = 651). Based on Scheimflug imaging, keratoconus was defined by a keratometric reading of ≥48 diopters (D) in any eye.
Purpose: To investigate the normative data of anterior chamber depth (ACD) and angle (ACA) and their associations in multiethnic cohorts spanning three generations in Russia.
Methods: The study cohort included the participants of three population-based studies performed in urban and rural Bashkortostan/Russia: The Ural Eye and Medical Study (UEMS; age:40+ years), Ural Children Eye Study (UCES; age:6-18 years), and Ural Very Old Study (UVOS; age:85+ years). Using Scheimflug camera-based anterior chamber imaging, we measured ACD and ACA as part of a comprehensive ophthalmological and systemic examination.
To examine the size of the ciliary body stroma (CBS) in dependence of the morphology of the anterior chamber angle in enucleated human eyes, we histomorphometrically examined human enucleated eyes. The study included 107 eyes (with a mean axial length of 25.1 ± 2.
View Article and Find Full Text PDFPurpose: To examine the spatial relationships between the retinal inner nuclear layer (INL), outer nuclear layer (ONL), retinal pigment epithelium (RPE) layer, Bruch's membrane (BM), and choriocapillaris in the parapapillary region.
Methods: Human eyes enucleated due to uveal melanomas or secondary angle-closure glaucoma were histomorphometrically examined. We compared the tissue dimensions between four groups of eyes categorized based on the presence/absence of high myopia and glaucoma.
Purpose: To describe the occurrence, morphology and associations of parapapillary drusen of the retinal pigment epithelium (RPE-drusen).
Methods: Using light microscopy, we histomorphometrically examined enucleated human eyes.
Results: The study included 83 eyes (axial length: 25.