Publications by authors named "Songhe Yin"
Article Synopsis
- - The study analyzed 94 patients with acute ischemic stroke to determine how serum inflammatory factors, specifically IL-6 and TNF-α, impact prognosis after revascularization therapy.
- - Patients were divided into good (mRS ≤ 2) and poor (mRS > 2) prognosis groups, with those in the good prognosis group showing lower levels of inflammatory markers and better clinical scores at admission.
- - The findings suggest IL-6 and TNF-α could be useful indicators for predicting recovery outcomes in stroke patients post-treatment, indicating that those with higher levels may have worse prognoses.
N6-methyladenosine (m6A) modification is the most abundant post-transcriptional modification of mRNAs and has been identified to play critical roles in ischemic stroke (IS). Herein, this study aimed to investigate the function and mechanism of Methyltransferase-like 14 (METTL14) methylase in cerebral IS. Murine BV-2 microglial cell OGD/R models and rat middle cerebral artery occlusion (MCAO) models were established to mimic IS-induced neuronal damage in vitro and brain injury in vivo.
View Article and Find Full Text PDFAmeliorated biomechanical properties of carotid arteries by puerarin in spontaneously hypertensive rats.
BMC Complement Med Ther
June 2021
Background: An emerging body of evidence indicates that puerarin (PUE) plays an important role in the treatment of angina pectoris, myocardial ischemia-reperfusion injury, hypertension and other cardiovascular diseases, but how PUE affects the vascular remodeling of hypertensive rats has not been reported yet. This study aimed to investigate the effect and mechanism of PUE on carotid arteries of spontaneously hypertensive rats (SHR) to provide the basis for the clinical application of PUE.
Methods: Thirty male SHR and six male Wistar Kyoto rats (WKY) aged 3 months were used in this study, SHR rats were randomly divided into 5 groups, PUE(40 or 80 mg/kg/d, ip) and telmisartan (TELMI) (30 mg/kg/d, ig) were administrated for 3 months.
Objective: We aim to explore the protective effect of bone marrow mesenchymal stem cells (BMSCs)-derived exosomal microRNA-221-3p (miR-221-3p) on ischemic stroke (IS) by targeting activating transcription factor 3 (ATF3).
Methods: The middle cerebral artery occlusion (MCAO) mice model and oxygen-glucose deprivation (OGD) neuron model were established. Extracellular vesicles were isolated from BMSCs (BMSC-EVs) and transfected with altered miR-221-3p or ATF3 to treat the MCAO mice and OGD-treated neurons.