Tandem mass tag-based proteomics analysis reveals the effects of Guri Gumu-13 pill on drug-induced liver injury.

The incidence of drug-induced liver injury (DILI) is second only to viral hepatitis and steatohepatitis in China, and DILI has become a serious public health problem that cannot be ignored. Guri Gumu-13 pill (GRGM) is a traditional Chinese medicine (TCM), which has a protective effect on liver diseases. However, the underlying therapeutic mechanisms of GRGM for DILI are still vague.

Effects of mongolian medicine Retz. on 6 CYP450 enzymes in rats.

Retz. (TCR) is a medicinal material commonly used in Mongolian medicine. After consulting the literature at home and abroad, current research on TCR focuses on chemical composition, pharmacodynamics, and fingerprints.

Magnetic solid-phase extraction based on magnetic amino modified multiwalled carbon nanotubes for the fast determination of seven pesticide residues in water samples.

A rapid and simple analytical method based on magnetic solid-phase extraction with magnetic amino modified multiwalled carbon nanotubes with ultra-high performance liquid chromatography-tandem mass spectrometry is reported for the determination of seven pesticides (futriafol, metalaxyl, myclobutanil, napropamide, epoxiconazole, fipronil and diniconazole) in water samples. In this study, magnetic amino modified multi-walled carbon nanotubes were synthesized and selected as a new kind of material to adsorb pesticides in the water samples. Various magnetic solid-phase extraction parameters, such as the amount and type of adsorbent, extraction methods, extraction time, the type and volume of desorption solvent, desorption time and solution ionic strength, were systematically optimized.