Publications by authors named "Song-guo He"
Article Synopsis
- The study investigates the role of TM6SF2 in fatty acid metabolism related to nonalcoholic fatty liver disease (NAFLD) and its implications for potential treatments.
- TM6SF2 levels were found to be elevated in patients and animal models with NAFLD, and its overexpression may help reduce liver fat accumulation.
- The findings suggest that TM6SF2 deficiency leads to increased lipid deposition due to disrupted fatty acid metabolism, and using the drug MK-4074 could potentially reverse NAFLD symptoms associated with this deficiency.
Background: This study aimed to investigate the clinical relevance of the immune microenvironment in patients with combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-ICC).
Patients And Methods: The density of tumor-infiltrating CD3 , CD8 , CD163 , and Foxp3 immune cells, as well as Programmed cell death 1, Programmed cell death-ligand 1, and Tumor necrosis factor receptor superfamily member 4, was measured in the peritumor liver, tumor invasive margin, and intratumor subregions of 56 cHCC-ICC by immunohistochemistry. The immune index was established to stratify patients.
Objective: To observe the expression of aquaporin 4 (AQP4) in diffuse brain injury (DBI) of rats and to explore the corresponding effect of AQP4 for brain edema.
Methods: The rat model of DBI was established using Marmarou's impact-compression trauma model. Brain water content was measured by dry-wet weight method.
Article Synopsis
- OCT1 was found to promote the development and progression of colorectal cancer (CRC), unlike its role in other cancers.
- The study showed that higher levels of OCT1 in CRC are linked to worse patient outcomes, including lower overall and disease-free survival rates.
- Targeting OCT1 could be a new strategy for CRC treatment, as its suppression reduced cancer cell growth in lab and animal models.