Publications by authors named "Song-Ting Bai"
[A multi-center epidemiological study on pneumococcal meningitis in children from 2019 to 2020].
Zhongguo Dang Dai Er Ke Za Zhi
February 2024
Objectives: To investigate the clinical characteristics and prognosis of pneumococcal meningitis (PM), and drug sensitivity of (SP) isolates in Chinese children.
Methods: A retrospective analysis was conducted on clinical information, laboratory data, and microbiological data of 160 hospitalized children under 15 years old with PM from January 2019 to December 2020 in 33 tertiary hospitals across the country.
Results: Among the 160 children with PM, there were 103 males and 57 females.
[Prognostic significance of coagulation disorders in children with hemophagocytic syndrome].
Zhongguo Dang Dai Er Ke Za Zhi
May 2014
Objective: To study the prognostic significance of coagulation disorders in children with hemophagocytic syndrome (HPS).
Methods: Thirty-five children with HPS were retrospectively studied to analyze the etiology, clinical characteristics, laboratory results and treatment outcomes.
Results: After treatment, 27 of the 35 HPS patients survived, and the other 8 cases died.
[Clinical efficacy of desmopressin in the treatment of mild hemophilia A in children].
Zhongguo Dang Dai Er Ke Za Zhi
September 2011
Objective: To study the effects of desmopressin (DDAVP) on coagulation factor Ⅷ (FⅧ) and activated partial thromboplastin time (APTT) in children with mild hemophilia A.
Methods: Eighteen children with mild hemophilia A were enrolled. DDAVP (0.
[Levels of Toll-like receptors-2,-4 on platelets in children with idiopathic thrombocytopenic purpura].
Zhongguo Dang Dai Er Ke Za Zhi
October 2009
Article Synopsis
- The study aimed to analyze the significance of TLR2 and TLR4 on platelets, CD86 on lymphocytes, and various cytokine levels in children with idiopathic thrombocytopenic purpura (ITP).
- Blood samples from children with acute and chronic ITP, as well as healthy controls, were examined using flow cytometry and ELISA techniques to measure specific markers and cytokine levels.
- The findings revealed that TLR2 and TLR4 expressions were lower in ITP groups compared to controls, while CD86 expression and cytokine levels were higher in ITP children, indicating potential biomarkers for understanding and predicting ITP in pediatric patients.
Objective: FMS-like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase that is constitutively activated in (70-90)% pediatric patients with acute myeloid leukemia (AML) and appears to confer an adverse prognosis. Although several FLT3-selective small molecule inhibitors and antibodies were developed with varied degrees of success, to address the specificity and resistance, new approaches for specifically targeted FLT3 are needed and RNA interference is a promising choice. The aim of the present study was to investigate the efficacy of suppression of FLT3 induced by small hairpin interfering RNA (shRNA) on myeloproliferation and apoptosis in an acute monocytic leukemia (AMOL) cell line THP-1.
View Article and Find Full Text PDF[In vitro transcription synthesis and effects of FLT3 targeted short hairpin RNA].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
August 2007
Article Synopsis
- FMS-like tyrosine kinase 3 (FLT3) is commonly activated in acute myeloid leukemia and is linked to poor patient outcomes.
- Three specific short hairpin RNAs (FLT3-shRNAs) were designed to silence FLT3 in THP-1 leukemia cells, with shRNA1 showing the strongest inhibition.
- After 72 hours of treatment with shRNA1, FLT3 mRNA and protein levels were significantly reduced, indicating its potential for future research on FLT3-targeted therapies.
Article Synopsis
- The study investigates the role of the CXCR4 receptor and its ligand SDF-1alpha in megakaryocyte function and platelet production in children with immune thrombocytopenic purpura (ITP).
- Findings show that children with ITP have significantly lower levels of CXCR4 and SDF-1alpha compared to healthy children, indicating a possible disruption in megakaryocyte maturation and platelet release.
- After treatment with high-dose intravenous immunoglobulin (HDIVIgG), children responsive to the treatment show increased levels of CXCR4 and SDF-1alpha, suggesting a potential link between these factors and treatment efficacy.