EFFECT OF GUIDING-HERB AND ON PAEONIFLORIN PHARMACOKINETICS OF XUEFU ZHUYU TANG IN RATS.

Background: Xuefu Zhuyu Tang (XFZYT), first recorded in by Qing-ren Wang, has been proven reliable and effective for curing various diseases such as atherosclerosis, hypertension, hyperlipidemia, and angina pectoris. It consists of 11 herbs and two of them, and , have been traditionally considered as guiding herbs and deeply valued by tens of millions of Chinese medicine practitioners. Do and affect the pharmacokinetics of the effective constituent-paeoniflorin of XFZYT? If yes, in what way? This study aims to answer these questions.

miR-143 regulates proliferation and apoptosis of colorectal cancer cells and exhibits altered expression in colorectal cancer tissue.

Colorectal cancer is one of the most commonly diagnosed cancers and a leading cause of death. Studies have shown that abnormal expression of microRNAs, small non-coding RNA molecules that regulate gene expression, is linked to the occurrence of cancer. This study sought to determine the role of microRNA-143 (miR-143) in colorectal cancer.

Overexpression of microRNA-21 and microRNA-126 in the patients of bronchial asthma.

MicroRNAs are implicated in an increasing number of diseases and health complications, including asthma. Previous studies have suggested roles for microRNA-21 (miR-21) and microRNA-126 (miR-126) in asthma, although these relationships are incompletely understood. The aim of this study was to further assess the relationship between miR-21, miR-126 and the occurrence and treatment of allergic asthma.

Curcumin treatment alters ERK-1/2 signaling in vitro and inhibits nasopharyngeal carcinoma proliferation in mouse xenografts.

Curcumin, a plant phenol, has been used for centuries in traditional medicines for its anti-inflammatory and anti-neoplastic properties. The compound is believed to act on a range of proteins involved in cell cycle regulation. In this study, the effect of curcumin on ERK-1/2 pathway protein expression and on proliferation of nasopharyngeal carcinoma cells was investigated.