Publications by authors named "Song-Ming Ding"
Article Synopsis
- This study investigates the accuracy of biliary tract cell brushing cytology during ERCP and aims to identify factors affecting diagnosis accuracy.
- It analyzed clinical data from patients treated between January 2016 and August 2019, focusing on various patient characteristics and test results.
- The findings indicate that 56.3% of patients had positive cytology results, with a sensitivity of 79.4% and specificity of 85.7%, supporting cell brushing as a reliable diagnostic method for pancreaticobiliary malignancies.
Article Synopsis
- * HUVEC-CM significantly enhances the invasion and migration of liver cancer cells (Bel-7402 and MHCC-LM3) through the activation of the integrins/FAK signaling pathway and up-regulation of MMP-3, though traditional epithelial-mesenchymal transition (EMT) is not involved.
- * While HUVEC-CM promotes apoptosis in certain liver cancer cell lines and modifies cell cycle phases, it does
Article Synopsis
- - The study investigates how MRC-5 cancer-associated fibroblasts influence cancer stem cell (CSC) markers and inflammation-related molecules in liver cancer cell lines, with some cells showing increased CSC characteristics when exposed to MRC-5 conditioned medium (CM).
- - Flow cytometry results indicated varying levels of CSC marker CD90 and inflammation markers like Toll-like receptors (TLR1 and TLR4) among different liver cancer cell lines when cultured in MRC-5 CM compared to normal medium.
- - Western blot analysis showed mixed regulation of key stem cell-related proteins (like Nanog and POU5F1) across different cell lines, indicating potential complexities in how these fibroblasts affect cancer biology and inflammation. *
Article Synopsis
- This study investigates the role of cancer-associated fibroblast MRC-5 in pancreatic cancer, an area previously underexplored compared to its impact on liver cancer.
- Using conditioned media from MRC-5, researchers found that it significantly repressed the colony formation, migration, and invasion abilities of pancreatic cancer cell lines SW1990 and PANC-1.
- The study suggests that MRC-5's effects are linked to changes in key cancer stem cell markers and immune-related molecules, indicating a potential mechanism for its inhibitory role in pancreatic tumor progression.
CADM1 regulates the G1/S transition and represses tumorigenicity through the Rb-E2F pathway in hepatocellular carcinoma.
Hepatobiliary Pancreat Dis Int
June 2016
Background: Increasing evidence indicates that downregulation of cell adhesion molecule 1 (CADM1) contributes to tumorigenesis in various cancers. The present study was undertaken to investigate the CADM1 expression pattern in human hepatocellular carcinoma (HCC), and to elucidate the mechanism underlying CADM1-mediated tumor suppression.
Methods: CADM1 expression in HCC cell lines was measured by quantitative real-time PCR.
Background And Purpose: Recently, evidence that Zinc transporter ZRT/IRT-like protein 4 (ZIP4) is involved in invasiveness and apoptosis has emerged in pancreatic cancer and prostate cancer. Our aim was to assess the role of ZIP4 in invasiveness, migration and apoptosis of hepatocellular carcinoma (HCC). The prognostic value of ZIP4 in HCC after liver transplantation was evaluated.
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- Microvascular invasion (MVI) is a serious risk factor indicating a poor prognosis in hepatocellular carcinoma (HCC) and is linked to the process of Epithelial-Mesenchymal Transition (EMT).
- A study found that higher levels of the transcription factor FOXC1 in HCC patients correlate with the presence of MVI, suggesting it plays a key role in disease progression.
- Targeting FOXC1 could potentially reduce tumor spread by reversing aspects of EMT, making it a promising therapeutic target for HCC treatment.
Article Synopsis
- A significant portion of liver transplant patients (20-40%) with hepatocellular carcinoma (HCC) experience tumor recurrence within five years, and current predictors are not adequate for identifying these patients.
- The study found that hypermethylation of the CADM1 gene is prevalent in HCC, leading to reduced expression and suggesting a potential mechanism for tumor recurrence.
- The research indicates that CADM1 methylation is a strong independent predictor of disease-free survival in HCC patients post-liver transplantation, highlighting its potential as a biomarker for assessing recurrence risk.