Publications by authors named "Song-I Lee"
Background: The incidence of sepsis with identified fungal pathogens is increasing and is associated with higher morbidity and mortality. Co-infection with fungal infections in COVID-19 patients is attracting clinical attention. This study examines the epidemiology, risk factors, and outcomes among sepsis patients with identified fungal pathogens.
View Article and Find Full Text PDFSepsis is a severe complication in patients with malignant tumors, leading to high mortality and increased need for intensive care. This study aimed to investigate the clinical characteristics and prognostic factors influencing sepsis outcomes in patients with malignant tumors. We included 4,858 patients with cancer diagnosed with sepsis between September 2019 and February 2020 whose data were collected from the Korean Sepsis Alliance, a nationwide multicenter cohort study.
View Article and Find Full Text PDFHaptoglobin (Hp) scavenges cell-free hemoglobin and correlates with the prognosis of human sepsis, a life-threatening systemic inflammatory condition. Despite extensive research on Hp glycosylation as a glyco-biomarker for cancers, understanding glycosylated modifications of Hp in sepsis patients (SPs) remains limited. Our study reveals elevated levels of terminal fucosylation at Asn207 and Asn211 of Hp in SP plasma, along with heightened inflammatory responses, compared to healthy controls (trial registration NCT05911711).
View Article and Find Full Text PDFBurnout among critical care physicians is an important issue that affects patient care and staff well-being. This study, conducted by the Korean Society of Critical Care Medicine, aimed to investigate the prevalence and associated factors of burnout among intensivists and critical care fellows in South Korea. From May to July 2019, a cross-sectional survey was conducted in 51 hospitals and 79 intensive care units offering subspecialty training in critical care medicine.
View Article and Find Full Text PDFBackground: Interleukin-6 (IL-6) plays a central role in sepsis-induced cytokine storm involving immune hyperactivation and early neutrophil activation. Programmed death protein-1 (PD-1) is associated with sepsis-induced immunosuppression and lymphocyte apoptosis. However, the effects of simultaneous blockade of IL-6 and PD-1 in a murine sepsis model are not well understood.
View Article and Find Full Text PDFArticle Synopsis
- - Sepsis poses significant risks to elderly patients (aged ≥ 80) due to their complex health issues, prompting a study to evaluate how underlying conditions and adherence to sepsis treatment protocols affect their outcomes.
- - The study analyzed data from nearly 12,000 patients, revealing that older survivors had better compliance with sepsis treatment bundles, including early fluid therapy and appropriate antibiotic use, compared to those who did not survive.
- - Findings emphasize the need for personalized treatment strategies and heightened awareness of the specific issues faced by older patients, suggesting that future research should focus on improving sepsis care interventions for this demographic.
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- Critically ill patients often lose muscle mass, which negatively impacts their recovery; this study aimed to assess how rehabilitation affects muscle mass in these patients.
- The study included 53 ICU patients, splitting them into rehabilitation (15 patients) and no rehabilitation groups (38 patients), measuring muscle mass with ultrasound and bioelectrical impedance analysis.
- After 14 days, the rehabilitation group showed improved muscle measurements and reduced muscle loss compared to the no rehabilitation group, suggesting rehabilitation may aid recovery, though survival rate differences were not statistically significant.
Article Synopsis
- - The study investigates how a rapid response system (RRS) impacts patient outcomes, specifically analyzing patients who were transferred to the ICU by a rapid response team (RRT) across nine hospitals in South Korea.
- - Out of 8,228 patients, 3,379 were moved to the ICU primarily due to issues like respiratory distress, sepsis, and septic shock, and the ICU group showed higher in-hospital and 28-day mortality rates compared to those who remained in the general ward.
- - Key factors influencing mortality included severity of illness, lower oxygen levels, and increased lactate and C-reactive protein levels, which indicate that patients transferred to the ICU typically have more severe health complications.
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- Tongue necrosis is a rare condition often linked to issues like vasculitis or septic shock, which can lead to serious damage and calcification.
- A case study details a 70-year-old man who experienced bilateral tongue necrosis after septic shock, with symptoms including discoloration and swelling, but without leg ischemia.
- Successful treatment involved cleaning the affected area, highlighting the importance of regular tongue inspection during ICU care to catch complications early and reduce long-term damage.
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- This study investigates the levels of soluble programmed death-ligand 1 (sPD-L1) in the bronchoalveolar lavage fluid (BALF) of patients with stage IV non-small cell lung cancer (NSCLC) to determine its prognostic and predictive significance.
- Researchers found a weak correlation between PD-L1 expression in tumors and sPD-L1 levels in BALF; patients with low sPD-L1 had significantly longer median overall survival (16.47 months) compared to those with high sPD-L1 (8.87 months).
- The findings suggest that sPD-L1 in BALF not only predicts how long patients might survive but also indicates how well they might
Article Synopsis
- Older age, particularly those over 80, is linked to worse outcomes in COVID-19 patients needing mechanical ventilation, with higher rates of organ dysfunction.
- A study collected data from 434 patients across 22 medical centers, revealing that geriatric patients had higher mortality rates and less aggressive treatment than those aged 65-79.
- Key factors influencing mortality included high creatinine levels and the use of specific life-sustaining treatments, emphasizing the need for tailored approaches to care for critically ill older patients.
Background: The coronavirus disease (COVID-19) pandemic has significantly strained global healthcare, particularly in the management of patients requiring mechanical ventilation (MV) and continuous renal replacement therapy (CRRT). This study investigated the characteristics and prognoses of these patients.
Methods: This multicenter retrospective cohort study gathered data from patients with COVID-19 across 26 medical centers.
Background: Limited data are available on the mortality rates of patients receiving extracorporeal membrane oxygenation (ECMO) support for coronavirus disease 2019 (COVID-19). We aimed to analyze the relationship between COVID-19 and clinical outcomes for patients receiving ECMO.
Methods: We retrospectively investigated patients with COVID-19 pneumonia requiring ECMO in 19 hospitals across Korea from January 1, 2020 to August 31, 2021.
Background: Increasing age has been observed among patients admitted to the intensive care unit (ICU). Age traditionally considered a risk factor for ICU mortality. We investigated how the epidemiology and clinical outcomes of older ICU patients have changed over a decade.
View Article and Find Full Text PDFClinical Manifestations and Outcomes of Older Patients with COVID-19: A Comprehensive Review.
Tuberc Respir Dis (Seoul)
April 2024
The consequences of coronavirus disease 2019 (COVID-19) are particularly severe in older adults with a disproportionate number of severe and fatal outcomes. Therefore, this integrative review aimed to provide a comprehensive overview of the clinical characteristics, management approaches, and prognosis of older patients diagnosed with COVID-19. Common clinical presentations in older patients include fever, cough, and dyspnea.
View Article and Find Full Text PDFBackground: In the intensive care unit (ICU), we may encounter patients who have completed a Do-Not-Resuscitate (DNR) or a Physician Orders to Stop Life-Sustaining Treatment (POLST) document. However, the characteristics of ICU patients who choose DNR/POLST are not well understood.
Methods: We retrospectively analyzed the electronic medical records of 577 patients admitted to a medical ICU from October 2019 to November 2020, focusing on the characteristics of patients according to whether they completed DNR/POLST documents.
The extracellular matrix (ECM) exerts physiological activity, facilitates cell-to-cell communication, promotes cell proliferation and metastasis, and provides mechanical support for tumor cells. The development of solid tumors is often associated with increased stiffness. A stiff ECM promotes mechanotransduction, and the predominant transcription factors implicated in this phenomenon are YAP/TAZ, β-catenin, and NF-κB.
View Article and Find Full Text PDFCathepsin C (CTSC), also known as dipeptidyl peptidase I, is a cathepsin with lysosomal exocysteine protease activity and a central coordinator for the activation of neutrophil-derived serine proteases in the lysosomes of neutrophils. Although the role of CTSC in various cancers, including liver and breast cancers, has recently been reported, its role in non-small cell lung cancer (NSCLC) is largely unknown. This study aimed to investigate the functional role of CTSC in NSCLC and the molecular mechanisms underlying CTSC involvement in disease progression.
View Article and Find Full Text PDFArticle Synopsis
- - This study examined how well radiographic scores and lab markers can predict rapid worsening of COVID-19 pneumonia in hospitalized patients, focusing on 218 cases.
- - Rapid progression, defined as needing mechanical ventilation within a week of admission, was found in 9.6% of patients, with the QMD score being the most effective predictor.
- - The research highlighted that even after negative COVID tests, some patients had lingering lung issues, emphasizing the importance of using AI-driven CT scores and lab data for monitoring and predicting disease progression.
During October 2022-March 2023, highly pathogenic avian influenza (HPAI) A(H5N1) clade 2.3.4.
View Article and Find Full Text PDFPulmonary large cell neuroendocrine carcinoma (LCNEC) is a rare and aggressive subtype of non-small cell lung cancer with a poor prognosis. Spontaneous regression, that is, partial or complete disappearance of a malignancy without medical intervention, is extremely rare in LCNEC. Herein, we present a case of spontaneous complete regression in a 71-year-old male patient with recurrent LCNEC after surgical resection.
View Article and Find Full Text PDFEvolution of the Stethoscope: Advances with the Adoption of Machine Learning and Development of Wearable Devices.
Tuberc Respir Dis (Seoul)
October 2023
The stethoscope has long been used for the examination of patients, but the importance of auscultation has declined due to its several limitations and the development of other diagnostic tools. However, auscultation is still recognized as a primary diagnostic device because it is non-invasive and provides valuable information in real-time. To supplement the limitations of existing stethoscopes, digital stethoscopes with machine learning (ML) algorithms have been developed.
View Article and Find Full Text PDFBackground/aims: For patients hospitalized with coronavirus disease 2019 (COVID-19) who require supplemental oxygen, the evidence of the optimal duration of corticosteroid is limited. This study aims to identify whether long-term use of corticosteroids is associated with decreased mortality.
Methods: Between February 10, 2020 and October 31, 2021, we analyzed consecutive hospitalized patients with COVID-19 with severe hypoxemia.
Article Synopsis
- The study investigates the use of biomarkers CRP, procalcitonin, and presepsin for diagnosing sepsis and predicting mortality in patients with severe acute kidney injury (AKI) starting continuous renal replacement therapy (CRRT).
- Out of 127 patients, 90 were diagnosed with sepsis, and both CRP and procalcitonin were found to be more effective than presepsin for this purpose.
- Higher levels of procalcitonin (≥3 ng/mL) and CRP (≥31 mg/L) were linked to increased mortality risk, alongside factors like lactic acid levels, sequential organ failure assessment score, and albumin levels.