Publications by authors named "Song-Hua Bei"
METTL5 promotes gastric cancer progression sphingomyelin metabolism.
World J Gastrointest Oncol
May 2024
Article Synopsis
- The treatment of gastric cancer (GC) is a significant global health challenge, and N6-methyladenosine (m6A) has been found to play a key role in tumor progression.
- METTL5, a methyltransferase linked to m6A, has been shown to be upregulated in GC, suggesting that higher levels of METTL5 are associated with poor patient outcomes and advanced cancer characteristics.
- The study conducted a series of experiments including cell assays and animal models, demonstrating that METTL5 promotes GC cell proliferation, migration, and invasion, while also affecting sphingomyelin metabolism and the cell's sensitivity to cisplatin.