Achieving Linear α-Macro-olefins in Ethylene Polymerization through Precisely Tuned Bis(imino)pyridylcobalt Precatalysts with Steric and Electronic Parameters.

Synthesis of functional polyethylene from ethylene alone is tricky and heavily dependent on both the type and structure of the precatalyst and the choice of cocatalyst used in the polymerization. In the present study, a series of cobalt precatalysts was prepared and investigated for ethylene polymerization under various conditions. By incorporation of strong electron-withdrawing groups (F and NO) and a steric component (benzhydryl) into the parent bis(imino)pyridine ligand, the catalytic performance of these precatalysts was optimized.

[Clinical diagnosis and treatment of pitch-related disorders].

Pitch abnormalities are a common manifestation of various voice disorders, with complex pathophysiological mechanisms involving changes in vocal fold tension, mass, and neuromuscular dysfunction of the larynx. This study aims to investigate the underlying physiological mechanisms of pitch-related disorders and explore diagnostic and therapeutic approaches, providing insights for clinical management.

Thermally stable -symmetric α-diimine nickel precatalysts for ethylene polymerization: semicrystalline to amorphous PE with high tensile and elastic properties.

In α-diimine nickel catalyst-mediated ethylene polymerization, adjusting catalytic parameters such as steric and electronic factors, as well as spectator ligands, offers an intriguing approach for tailoring the thermal and physical properties of the resulting products. This study explores two sets of -symmetric α-diimine nickel complexes-nickel bromide and nickel chloride-where -steric and electronic substituents, as well as nickel halide, were varied to regulate simultaneously chain walking, chain transfer, and the properties of the polymers produced. These complexes were activated with EtAlCl, resulting in exceptionally high catalytic activities (in the level of 10-10 g (PE) mol (Ni) h) under all reaction conditions.

An Analysis of the Effects of Predictive Early Nutritional Care Interventions in Patients Undergoing Maintenance Haemodialysis.

Objective: To study the effect of predictive early nutritional care intervention on gastrointestinal function, Subjective global nutritional assessment (SGA) score, serum albumin (ALB) and high-sensitivity C-reactive protein (hs CRP), quality of life and quality of sleep in patients on maintenance haemodialysis.

Methods: A total of 90 cases of maintenance hemodialysis patients in our hospital were collected from March 2020 and randomly divided into two groups of 45 cases each. The control group was cared for according to routine procedures.

Interleukin-37 promotes DMBA/TPA skin cancer through SIGIRR-mediated inhibition of glycolysis in CD103DC cells.

Interleukin 37 (IL-37), a member of the IL-1 family, is considered a suppressor of innate and adaptive immunity and, hence is a regulator of tumor immunity. However, the specific molecular mechanism and role of IL-37 in skin cancer remain unclear. Here, we report that IL-37b-transgenic mice (IL-37tg) treated with the carcinogenic 7,12-dimethylbenzoanthracene (DMBA)/12-o-tetradecylphorbol-13-acetate (TPA) exhibited enhanced skin cancer and increased tumor burden in the skin by inhibiting the function of CD103 dendritic cells (DCs).

Microalgal glycerol-3-phosphate acyltransferase role in galactolipids and high-value storage lipid biosynthesis.

Glycerolipids are the most abundant lipids in microalgae, and glycerol-3-phosphate:acyl-CoA acyltransferase (GPAT) plays an important role in their biosynthesis. However, the biochemical and biological functions of algal GPAT remain poorly characterized. Here, we characterized the endoplasmic reticulum (ER)-associated GPAT of the model unicellular green alga Chlamydomonas reinhardtii (CrGPATer).

Visible-Light-Driven Reductive Carboxylation of Benzyl Bromides with Carbon Dioxide Using Formate as Terminal Reductant.

Cheap and available formate can be seen formally as a carbon dioxide radical anion (CO) combined with a hydrogen atom, where the CO is not only a highly active radical but also a very powerful reductant. In this paper, we successfully realized a visible-light-driven carboxylation of benzyl bromides with carbon dioxide to prepare high-value arylacetic acids using potassium formate as a terminal reductant. This reaction is characterized by mild reaction conditions and a wide range of substrates.

Gut Microbiota Dysbiosis and Altered Bile Acid Catabolism Lead to Metabolic Disorder in Psoriasis Mice.

Patients with psoriasis tend to have significant comorbidities, such as hyperlipemia, diabetes mellitus, and obesity, which belong to metabolic disorders. The specific mechanism through which psoriasis increases the metabolic disorder risk is uncertain. In this study, we demonstrated that the dysbiotic gut microbiota of 6-month-old psoriasis-like model mice (K14-VEGF-A-transgenic) exacerbated psoriasis disease and induced metabolic disorder when transferred into 2-month-old mice.

Photoredox-catalyzed fluorodifluoroacetylation of alkenes with FSOCFCOMe and EtN·3HF.

Photoredox-catalyzed three-component fluorodifluoroacetylation of aromatic alkenes is reported, which features a wide substrate scope and functional group tolerance. An advantage of the reaction is the use of a nucleophilic fluoride source and a general difluoroacetylation reagent for the fluorodifluoroacetylation of alkenes.

A Novel Bifunctional Wax Ester Synthase Involved in Early Triacylglycerol Accumulation in Unicellular Green Microalga Under High Light Stress.

The bulk of neutral lipids, including astaxanthin esters and triacylglycerols (TAGs), are accumulated in the green microalga under high light (HL) stress. In this study, a novel bifunctional wax ester synthase (WS) gene was cloned from upon HL stress. The overexpression of HpWS restored the biosynthesis of wax esters and TAGs in neutral lipid-deficient yeast mutant H1246 fed with C18 alcohol and C18:1/C18:3 fatty acids, respectively.

Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction.

Interleukin-37b (hereafter called IL-37) was identified as fundamental inhibitor of natural and acquired immunity. The molecular mechanism and function of IL-37 in colorectal cancer (CRC) has been elusive. Here, we found that IL-37 transgenic (IL-37tg) mice were highly susceptible to colitis-associated colorectal cancer (CAC) and suffered from dramatically increased tumor burdens in colon.

MeOTf/KI-catalyzed efficient synthesis of 2-arylnaphthalenes cyclodimerization of styrene oxides.

The MeOTf/KI-catalyzed synthesis of 2-arylnaphthalene derivatives from aryl ethylene oxides in alcohol under ambient conditions is described. The present protocol has a higher atom efficiency and wider substrate applicability with excellent yields. The reaction proceeded using the aryl ethylene oxides to give 2-arylnaphthalenes either in homo-coupling or in cross-coupling.

EDIL3 deficiency ameliorates adverse cardiac remodelling by neutrophil extracellular traps (NET)-mediated macrophage polarization.

Aims: After myocardial infarction (MI), injured cardiomyocytes recruit neutrophils and monocytes/macrophages to myocardium, which in turn initiates inflammatory and reparative cascades, respectively. Either insufficient or excessive inflammation impairs cardiac healing. As an endogenous inhibitor of neutrophil adhesion, EDIL3 plays a crucial role in inflammatory regulation.

Metabolic Syndrome and Psoriasis: Mechanisms and Future Directions.

Psoriasis is an immune-mediated systemic disease with associated comorbidities, including metabolic syndrome (MetS) which contributes substantially to premature mortality in patients with psoriasis. However, the pathological mechanisms underlying this comorbidity are unclear. Studies have shown that the pathological parameters of psoriasis mediate the development of MetS.

The impact of exercise training for chronic heart failure patients with cardiac resynchronization therapy: A systematic review and meta-analysis.

Background And Objective: Systematically review the current published literature on the impact of exercise training (ET) in chronic heart failure (CHF) patients who were conducted cardiac resynchronization therapy (CRT).

Methods: PubMed, EMBASE, and the Cochrane Library of Controlled Trails databases were searched for trials comparing the additional effects of ET in CHF patients after CRT implantation with no exercise or usual care control up until 2020.03.

Electrophysiological study and radiofrequency ablation of hemodynamically-instable ventricular arrhythmias in a patient with pulmonary hypertension: A case report.

Introduction: Hemodynamically-instable ventricular arrhythmias (VAs) are rare in patients with pulmonary hypertension (PH). To the best of our knowledge, only 1 case has been reported so far. Moreover, the pathogenesis of this kind of arrhythmia remains obscured and its treatment is challenging.

The ratio of main pulmonary artery to ascending aorta diameter is associated with the right ventricular outflow tract ventriculararrhythmias.

Background: Although outflow tract (OT) ventricular arrhythmias (VAs) are generally regarded as benign, the relationship between circulation pressure and VAs has received considerable attention in recent years. Previous studies have shown that the ratio of main pulmonary artery (MPA) to ascending aorta (AA) diameter is associated with pulmonary pressure. Here, we investigated whether an elevated MPA/AA ratio is associated with right ventricular OT (RVOT) VAs.

Merging three-dimensional CT with electroanatomic mapping facilitates ablation of ventricular arrhythmias originating from aortic root and great cardiac vein.

Purpose: In radiofrequency ablation near coronary arteries (CA), coronary angiography is traditionally recommended to estimate distance between catheter and CA. This study aimed to investigate the feasibility of an alternative approach for intuitively demonstrating spatial location of catheter and CA during ablation of ventricular arrhythmias (VAs) originating from aortic root (AR) and great cardiac vein (GCV).

Methods: During mapping and ablation, 3D-reconstructed cardiac CT and electroanatomic mapping were merged, and distance between CA and catheter was monitored.

Autophagy-based unconventional secretion of HMGB1 by keratinocytes plays a pivotal role in psoriatic skin inflammation.

The precise mechanism through which macroautophagy/autophagy affects psoriasis is poorly understood. Here, we found that keratinocyte (KC) autophagy, which was positively correlated with psoriatic severity in patients and mouse models and could be inhibited by mitogen-activated protein kinase (MAPK) family inactivation. The impairment of autophagic flux alleviated psoriasisform inflammation.

Microstructure and Pitting Corrosion of Austenite Stainless Steel after Crack Arrest.

With synergy of plastic deformation near crack tip and pulse current treatment, complex phase transformation and recrystallization occur in the metallographic structure, with the austenite transforming to fine grain structure and deformation-induced martensite; but, without the plastic deformation, the phase transformation, and recrystallization it was difficult for the crack arrest process to take place only undergoing the pulse current treatment. The nano-indentation experiment showed that the phase transformation region contained the maximum residual compressive stress consisting of four parts: the plastic stress, the explosion stress, the thermal stress, and the transformation stress, which was beneficial to restrain the crack growth. However, the solidification structure and the deformation-induced martensite structure was vulnerable to pitting corrosion through scanning microelectrode technology (SMET) and pitting corrosion experiment, but the pitting corrosion resistance could be improved through the solution heat treatment.

The impact of renal function on efficacy and safety of new oral anticoagulant in atrial fibrillation patients: A systemic review and meta-analysis.

Background And Objectives: This meta-analysis was to investigate the efficacy and safety of new oral anticoagulant (NOAC) in atrial fibrillation (AF) patients with renal function insufficiency, and to explore whether renal decline occurs in AF patients with NOAC and its impact on outcomes.

Methods And Results: In AF patients with mild renal insufficiency, the NOAC was associated with significantly lower rates of stroke (odds ratio [OR], 0.78; 95% confidence interval [CI], 0.

Concise and Efficient Synthesis of Indole-Indolone Scaffolds through MeOTf-Induced Annulation of -(2-Cyanoaryl)indoles.

MeOTf-triggered annulation of -(2-cyanoaryl)indoles to provide indolo[1,2-]indol-10-imines and the corresponding indolo[1,2-]indol-10-ones have been described under metal-free conditions. A variety of functional groups are tolerated in their scaffolds with good to excellent yields. The reaction could be carried to gram scale.

Copper-Catalyzed Regioselective Aminothiolation of Aromatic and Aliphatic Alkenes with -Fluorobenzenesulfonimide and Thiols through Three-Component Radical Coupling.

Copper-catalyzed regioselective aminothiolation of terminal and internal alkenes with -fluorobenzenesulfonimide and thiols has been developed. The three-component reaction is promoted by the addition of dimethyl sulfide. In addition to aromatic alkenes, aliphatic alkenes are subjected to the reaction, affording various aminothiolation adducts as single regioisomers.

ROTf-induced annulation of heteroatom reagents and unsaturated substrates leading to cyclic compounds.

The development of metal-free organic reactions is one of the hotspots in the synthesis of cyclic compounds. ROTf (alkyl trifluoromethanesulfonates), due to their good electrophilicity, are powerful alkylating reagents at heteroatoms such as nitrogen, oxygen, sulfur and phosphorus to induce an electrophilic centre for carbon-carbon or carbon-heteroatom bond formation. Inspired by this chemistry, a variety of research concentrating on heterocycles synthesis has been carried out.