Positive association of triglyceride glucose index and gestational diabetes mellitus: a retrospective cohort study.

Background: Gestational diabetes mellitus (GDM) is a common metabolic disorder with important health implications for both mother and offspring. This study aims to assess the relationship between the Triglyceride Glucose (TyG) index and GDM and explore its clinical significance.

Methods: A retrospective cohort study included 631 singleton pregnant women.

Real-world effectiveness and safety of oral azvudine versus nirmatrelvir‒ritonavir (Paxlovid) in hospitalized patients with COVID-19: a multicenter, retrospective, cohort study.

Azvudine and nirmatrelvir-ritonavir (Paxlovid) were widely used to treat patients with COVID-19 in China during the Omicron wave. However, the efficacy and safety of azvudine versus Paxlovid are poorly established. This study included 40,876 hospitalized patients with COVID-19 from eleven hospitals in Henan and Xinjiang Provinces, China.

The positive impact of targeted modulating food intolerance on immune-related recurrent pregnancy loss.

Background: It has been proven that immune disorders are one of the vital risk factors of recurrent pregnancy loss (RPL), and the presence of food intolerance seems to play an essential role in this. However, the impact of immune status induced by food intolerance on RPL has not been reported. This study utilized a targeted diet avoiding food intolerance as much as possible for each participant to investigate their effects on pregnancy outcomes in RPL patients with positive autoimmune markers.

The effects of metabolic indicators and immune biomarkers on pregnancy outcomes in women with recurrent spontaneous abortion: a retrospective study.

Background: The etiology of recurrent spontaneous abortion (RSA) remains elusive despite specific investigations affirming the association between RSA and thyroid autoimmunity (TAI). This study explores the immunological and metabolic profiles of RSA patients exhibiting positive thyroid antibodies and their connection with the rates of first-trimester miscarriage and live births. The aim is to provide further guidance for clinical interventions.

High-Capacity Spatial Structured Light for Robust and Accurate Reconstruction.

Spatial structured light (SL) can achieve three-dimensional measurements with a single shot. As an important branch in the field of dynamic reconstruction, its accuracy, robustness, and density are of vital importance. Currently, there is a wide performance gap of spatial SL between dense reconstruction (but less accurate, e.

In vivo study revealed pro-tumorigenic effect of CMTM3 in hepatocellular carcinoma involving the regulation of peroxisome proliferator-activated receptor gamma (PPARγ).

Purpose: To clarify the ambiguity of the function of CMTM3 in the development of hepatocellular carcinoma (HCC) and explore its molecular mechanism.

Methods: The Cmtm3-KO C57BL/6 mouse strain was established using CRISPR-Cas9. Acute liver damage and HCC models were induced by peritoneal injection of 100 or 25 mg/kg.

Protective effect of melatonin on alleviating early oxidative stress induced by DOX in mice spermatogenesis and sperm quality maintaining.

Doxorubicin (DOX) is an effective chemotherapy drug, but its clinical use has adverse effects on male reproduction. However, there are few studies about the specific biological processes related to male reproduction or strategies for improving fertility protection. In this paper, we examined the effects of DOX on spermatogenesis and sperm function, and tested the possible protective role of melatonin (MLT) against DOX's reproductive toxicity.

Melatonin ameliorates paclitaxel-induced mice spermatogenesis and fertility defects.

Chemotherapeutic drug of paclitaxel (PTX) has been shown to cause reproductive toxicity thus affecting male fertility, but its underlying molecular basis is unclear. Melatonin (MLT) can mitigate the reproductive damage caused by certain chemotherapy drugs. In this study, we aimed to identify impact of PTX on the main biological processes and protective effect of MLT on reproductive damage caused by PTX.

Expressions of HSPA1L and HSPA9 are associated with poor sperm quality of low-motility spermatozoa in fertile men.

Human semen is a heterogeneous group containing a portion of low-motility sperm, which may determine the sperm quality evaluation. Abnormally expressed proteins in low-motility spermatozoa will be the candidates for sperm biology research. By comparing proteomes of high- or low-motility spermatozoa from the same semen of normal fertile men, 21 differentially expressed proteins were identified.

Customized exogenous ferredoxin functions as an efficient electron carrier.

Ferredoxin (Fdx) is regarded as the main electron carrier in biological electron transfer and acts as an electron donor in metabolic pathways of many organisms. Here, we screened a self-sufficient P450-derived reductase PRF with promising production yield of 9OHAD (9α-hydroxy4-androstene-3,17-dione) from AD, and further proved the importance of [2Fe-2S] clusters of ferredoxin-oxidoreductase in transferring electrons in steroidal conversion. The results of truncated Fdx domain in all oxidoreductases and mutagenesis data elucidated the indispensable role of [2Fe-2S] clusters in the electron transfer process.

Weakly Aligned Feature Fusion for Multimodal Object Detection.

To achieve accurate and robust object detection in the real-world scenario, various forms of images are incorporated, such as color, thermal, and depth. However, multimodal data often suffer from the position shift problem, i.e.

Genome-Wide Expression Difference of MicroRNAs in Basal Cell Carcinoma.

Distinct expression of the miRNAs has rarely been explored in basal cell carcinoma (BCC) of skin, and the regulatory role of miRNAs in BCC development remains quite opaque. Here, we collected control tissues from adjacent noncancerous skin ( = 15; control group) and tissues at tumor centers from patients with cheek BCC ( = 15; BCC group) using punch biopsies. After six small RNA sequencing- (sRNA-seq-) based miRNA expression profiles were generated for both BCC and controls, including three biological replicates, we conducted comparative analysis on the sRNA-seq dataset, discovering 181 differentially expressed miRNAs (DEMs) out of the 1,873 miRNAs in BCCs.

Diagnosis values of IL-6 and IL-8 levels in serum and bronchoalveolar lavage fluid for invasive pulmonary aspergillosis in chronic obstructive pulmonary disease.

Among immunologically normal hosts, patients with chronic obstructive pulmonary disease (COPD) are considered to be at high risk of invasive pulmonary aspergillosis (IPA), and early diagnosis and treatment are the key to improving the prognosis of patients. Here we aimed to evaluate whether interleukin (IL)-6 and IL-8 might be used in the detection and diagnosis of IPA in patients with COPD. We prospectively collected 106 patients with COPD and divided them into non-IPA (n=74), probable/possible IPA (n=26) and proven IPA (n=6).

3D reconstruction of the specular surface using an iterative stereoscopic deflectometry method.

Phase measuring deflectometry (PMD) is an effective technique for three-dimensional measurement of specular surfaces. However, the ambiguity of monoscopic PMD and the time-consuming searching process of stereoscopic PMD are challenges for specular surface reconstruction. To solve it, we propose an iterative reconstruction algorithm for the stereoscopic phase measuring deflectometry system free of the time-consuming searching process for each pixel.

Enhancing the sustainability of KsdD as a biocatalyst for steroid transformation by immobilization on epoxy support.

The Δ1-dehydrogenation of 3-ketosteroid substrates is a crucial reaction in the production of steroids. Although 3-ketosteroid Δ1-dehydrogenase (KsdD) catalyzes this reaction with high efficiency and selectivity, the low stability and high cost of the purified enzyme catalyst have limited its industrial application. In this study, an epoxy support was used to evaluate the covalent immobilization of KsdD from Pimelobacter simplex, and the best androsta-1,4-diene-317-dione (ADD) production was achieved after optimized immobilization of KsdD enzyme in 1.

Establishment and characterization of a gill cell line from pearl gentian grouper (Epinephelus lanceolatus♂×Epinephelus fuscoguttatus♀) and its application in cadmium toxicology.

A novel gill cell line from pearl gentian grouper (Epinephelus lanceolatus♂×Epinephelus fuscoguttatus♀, PGGG cell line) was established, its application in cadmium (Cd) toxicology was demonstrated in this study. Primary cultures and PGGG subcultures were carried out at 25 °C in Dulbecco's Modified Eagle medium/F12 medium (1:1; pH 7.2) supplemented with 15% fetal bovine serum (FBS).

Dot-coded structured light for accurate and robust 3D reconstruction.

Speckle dots have the advantage of easy projection, which makes them good candidate features of structured light (SL) cameras, such as Kinect v1. However, they generally yield poor accuracy due to block matching. To improve their accuracy, this paper proposes a dot-coded SL, the coding information of which is added into dot distribution.

Eliminating the Effect of Reflectance Properties on Reconstruction in Stripe Structured Light System.

The acquisition of the geometry of general scenes is related to the interplay of surface geometry, material properties and illumination characteristics. Surface texture and non-Lambertian reflectance properties degrade the reconstruction results by structured light technique. Existing structured light techniques focus on different coding strategy and light sources to improve reconstruction accuracy.

Expression, Purification, Refolding, and Characterization of a Protein From .

Steroid hormones that serve as vital compounds are necessary for the development and metabolism of a variety of organisms. The (NVD) family genes encode the conserved Rieske-type oxygenases, which are accountable for the dehydrogenation during the synthesis and regulation of steroid hormones. However, the His-tagged NVD protein from expresses as inclusion bodies in BL21 (DE3).

Micrometer-level 3D measurement techniques in complex scenes based on stripe-structured light and photometric stereo.

Compared with existing depth cameras, such as RGB-D, RealSense and Kinect, stripe-based structured light (SL) has the potential for micrometer-level 3D measurement; this can be attributed to its higher coding capacity. While surface texture, high-reflective region, and occlusion remain some of the main sources leading to degraded reconstruction quality in complex objects, methods that are only based on SL cannot completely solve such problems in complex object reconstruction. In this paper, we developed an advanced fusion strategy for the reconstruction of complex objects in micrometer-level 3D measurement.

Accurate infrared structured light sensing system for dynamic 3D acquisition.

3D real-time acquisition plays a vital role in computer graphics and computer vision. In this paper, we present a dynamic IR structured light sensing system with high resolution and accuracy for real-time 3D scanning. We adopt the Gray code combined with stripe shifting as our 3D acquisition's coding strategy and parallelize the algorithm via the GPU in our IR 3D scanning system.

Single-Shot Structured Light Sensor for 3D Dense and Dynamic Reconstruction.

Structured light (SL) has a trade-off between acquisition time and spatial resolution. Temporally coded SL can produce a 3D reconstruction with high density, yet it is not applicable to dynamic reconstruction. On the contrary, spatially coded SL works with a single shot, but it can only achieve sparse reconstruction.

An Accurate Calibration Means for the Phase Measuring Deflectometry System.

Calibration is a critical step for the phase measuring deflectometry system. Existing calibration methods are mainly optimizing the calibration parameters with respect to the 2D re-projection error criterion. However, such a procedure cannot reduce metric errors in the practical application.

Mesh-Based Computation for Solving Photometric Stereo With Near Point Lighting.

We tackle the problem of dense reconstruction with a practical system, in which near point lighting (NPL) is employed. Different from the conventional formulation of photometric stereo (PS) that assumes parallel lighting, PS under the NPL condition is a nonlinear problem as the local surface normals are coupled with its distance to the camera as well as the light sources. After obtaining the locations of point lights by a calibration process, we develop a new framework to solve this nonlinear reconstruction problem via mesh deformation, in which each facet is corresponding to a pixel in the image captured by the camera.