Design, synthesis and inhibition evaluation of novel chalcone amide α-glucosidase inhibitors.

The purpose of this study is to design and synthesize a series of novel chalcone amide α-glucosidase (AG) inhibitors () based on virtual screening and molecular dynamics (MD) simulation. Target compounds () were synthesized from 2-hydroxyacetophenone and methyl 4-formylbenzoate. activity test shows that most compounds have good AG inhibition.