Self-assembled injectable Icariin@ TiCTx/doxorubicin hydrogel preserving osteogenesis while synergizing photodynamic and chemodynamic therapy for osteosarcoma.

Local therapy involving injectable hydrogel systems loaded with doxorubicin (DOX) has garnered significant attention in the realm of osteosarcoma (OS) research. Nevertheless, it has been noted that the local delivery of high-dose DOX exerts a pronounced inhibitory impact on osteogenesis, which is detrimental to the restoration of functional capabilities after OS treatment. To address this challenge, we have designed a self-assembled injectable hydrogel system that integrates photodynamic and chemodynamic therapy, aiming to enhance efficacy while mitigating adverse effects on osteogenic differentiation.

Design and development of drug delivery nanocarriers based on liquid-liquid phase separation, improved stability, cell-penetration and anti-cancer effect.

Liquid-liquid phase separation (LLPS) of nuclear pore complex (NPC) with nuclear transport proteins (NTPs) via intrinsically disordered regions (IDRs) plays a crucial role in the nucleocytoplasmic transport. The development of efficient targeted delivery systems based on LLPS has attracted widespread attention. Here, we developed nanocarriers of casein peptides, a natural intrinsically disordered proteins (IDPs), modified with fatty acids of different alkyl chains (C10-C18) and decorated by shellac for highly effective drug delivery and cancer therapy.

Ergosterol originated from attenuates high fat diet-induced obesity and cognitive impairment in mice.

Excessive intake of a high fat diet (HFD) leads to accumulation of fat and obesity. Ergosterol (ERG) is a characteristic sterol of fungi with various bioactive functions; however, there are few studies on the ERG function of ameliorating obesity and following cognitive impairment. It was previously found that Zhashui (AA) is rich in ERG; therefore it was selected to enrich ERG through the intervention of exogenous inducers of rice bran oil (RBO), methyl jasmonate (Me JA) and salicylic acid (SA).

Association of atrial cardiopathy and residual shunt after patent foramen ovale closure in patients experiencing migraine.

Aims: Migraine is a prevalent and incapacitating condition. The association between patent foramen ovale (PFO) and migraine-type headaches has been extensively documented. In clinical practice, patients may observe residual shunting after PFO closure.

Association of maternal metabolic risk factors with offspring body mass index (BMI) trajectories in early childhood: a retrospective cohort study.

Objective: This study aimed to identify body mass index (BMI) growth trajectories from birth to 24 months of age and examine the independent and additive effects of four maternal metabolic risk factors, namely prepregnancy BMI, the rate of gestational weight gain, gestational diabetes mellitus (GDM) and gestational hypertension, on offspring growth trajectories in childhood in China.

Design: A retrospective cohort study was conducted.

Setting: The study used Maternal and Child Health Management Database in Chengdu, China, including the mothers' antenatal care data, birth certificate records and 0-3-year-old children's healthcare data.

Combined skin injury model from airblast overpressure and seawater immersion in rats: establishment, characterization, and mechanistic insights.

In maritime operations, individuals often face the threat of combined injury caused by airblast overpressure and seawater immersion. Airblast overpressure, induced by explosions, leads to significant internal damage despite the absence of visible open wounds. Seawater immersion exacerbates injuries due to its high osmolarity, microbial content, and thermal conductivity.

Test-retest reliability and practice effects of shape trail test in stroke patients.

Objective: Executive dysfunction after stroke greatly affects stroke prognosis, so clinicians need to urgently focus on screening for it. This study aims to offer valuable data for research on post-stroke executive dysfunction by evaluating the test-retest reliability of the Shape Trail Test (STT) and the influence of the practice effect on scores among stroke patients.

Methods: A total of 75 subacute stroke patients were included in the study.

Chinese Expert Consensus on the Diagnosis and Treatment of Inflammatory Myofibroblastic Tumor.

Inflammatory myofibroblastic tumor (IMT) is a rare spindle-cell neoplasm. IMT currently suffers from a paucity of standardized diagnostic and therapeutic guidelines. The Chinese expert consensus committee on the diagnosis and treatment of IMT formed an "Expert consensus on the diagnosis and treatment of inflammatory myofibroblastic tumor".

Cysteine-assisted synthesis of copper nanoclusters for construction of FRET-based ratiometric sensor for visual detection of alkaline phosphatase.

Abnormal alkaline phosphatase (ALP) levels in the human body are closely associated with various diseases, particularly hepatobiliary diseases and bone diseases. Herein, we constructed a ratiometric sensor based on Förster resonance energy transfer (FRET) using strongly photoluminescent copper nanoclusters (Cu NCs) for the detection of ALP with high sensitivity and specificity. The cysteine-stabilized Cu NCs (Cys-Cu NCs) were synthesized through a ligand-exchange reaction and core-size etching focusing, which displayed bright photoluminescence (PL) with a quantum yield (QY) of 10.

Hashimoto's thyroiditis recognition from multi-modal data via global cross-attention and distance-aware training.

Ultrasound images and biological indicators, which reveal Hashimoto's thyroiditis (HT) characteristics in thyroid tissue from different perspectives, play crucial roles in HT recognition. Ultrasound images of patients with HT typically present a heterogeneous background with potential decreases in echogenicity. Clinicians are prone to misdiagnosing HT by visually evaluating these characteristics.

Design and testing of the key technology of the cotton direct seeding machine.

The paper aims to slove the problems of low sowing depth qualification index and poor seeding stability during in summer direct-sown cotton in the Yangtze River Basin China. To this end, a cotton seeder with rotary tillage and electric drive seeding was designed. In order to satisfy the agronomic requirements of summer direct-sown cotton, the key structural parameters of this planter were determined, and the key factors affecting the stability of seeding depth were derived.

A new vetivane-type sesquiterpenoid with a tricyclic 7/5/5 scaffold from the endophytic fungus 2021CDF-3.

Natural sesquiterpenoids possess a variety of skeleton types with intriguing biomedical activities. In this study, a comprehensive chemical study of the endophytic fungus 2021CDF-3 yielded a new sesquiterpenoid, namely penicivetivane A (). The chemical structure for was thoroughly ascertained by using HRESIMS and NMR spectroscopic analyses, while the stereochemistry of was further verified by X-ray diffraction analyses.

Label-free upconversion nanosensor for water safety monitoring of permanganate and dichromate ions.

Water contaminated with heavy metal ions poses serious threat to the human health and environment protection. It is imperative to develop analytical tools to detect heavy metal ions. Herein, we propose autofluorescence free SiO modified upconversion nanosensor for label-free and fast determination of MnO and CrO anions.

Dietary specialization among individual squid: using as a case and meta-analysis for other squid species.

Squid, which occupy a similar role to teleost fish as open water predators, are opportunistic foragers. However, there is a lack of empirical evidence related to whether individual squid specialize their diets to optimize fitness. We investigated whether individual squid have specialized diets and what factors impact any specialization using the Argentine shortfin squid as a case study species, coupled with a meta-analysis for other squid species.

DSANIB: drug-target interaction predictions with dual-view synergistic attention network and information bottleneck strategy.

Prediction of drug-target interactions (DTIs) is one of the crucial steps for drug repositioning. Identifying DTIs through bio-experimental manners is always expensive and time-consuming. Recently, deep learning-based approaches have shown promising advancements in DTI prediction, but they face two notable challenges: (i) how to explicitly capture local interactions between drug-target pairs and learn their higher-order substructure embeddings; (ii) How to filter out redundant information to obtain effective embeddings for drugs and targets.

Design and analysis of magnetic circuit for mass transfer 6-DOF magnetic levitation platform.

Mini/Micro LED is a new display technology, it has advantages of long-life, energy-saving, fast response speed and brightness. The mass transfer speed of Mini/Micro LED is main challenge for its large-scale application. Magnetic levitation platform with long stroke is vital to increase the mass transfer speed.

Synergistic restoration of spinal cord injury through hyaluronic acid conjugated hydrogel-polydopamine nanoparticles combined with human mesenchymal stem cell transplantation.

Spinal cord injury (SCI) is a devastating disease with limited treatment options due to the restricted regenerative capacity of the central nervous system. The accumulation of reactive oxygen species (ROS) and inadequate endogenous neural stem progenitor cells (eNSPCs) in the lesion site exacerbates neurologic deficits and impedes motor function recovery. We have developed a temperature-responsive hyaluronic acid conjugated hydrogel-polydopamine nanoparticles (PDA NPs) combined with human mesenchymal stem cell (hMSCs) transplantation, denoted as H-P-M hydrogel.

Unleashing the Healing Power: 3D Bioprinting Mimics Hypoxia to Supercharge Mesenchymal Stem Cells.

Mesenchymal stem cells (MSCs) play a critical role in stem cell therapy due to their tissue-mimicking abilities. However, conventional 2D culture conditions often lead to the loss of their native hypoxic niche, potentially limiting their therapeutic efficacy. 3D bioprinting offers a method to recreate intricate biological environments by integrating cells with extracellular matrices.

Large-scale metabolomic landscape of edible maize reveals convergent changes in metabolite differentiation and facilitates its breeding improvement.

Edible maize is an important food crop, providing energy and nutrients to meet human health and nutritional requirements. However, how environmental pressures and human activity have shaped the edible maize metabolome remains unclear. In this study, we collected 452 diverse edible maize accessions worldwide, comprising waxy, sweet, and field maize.

Protocol for identifying protein synthesis activity in specific cell types of the testicular lumen.

Protein synthesis could control spermatogenic cell fate transitions. Here, we present a protocol for visualization and quantification of newly synthesized proteins by click-chemistry-based immunofluorescence within specific spermatogenic cell types in the mice testicular lumen. We detail the processes for O-propargyl-puromycin (OPP) incorporation, antibody incubation, confocal microscope imaging, and subsequent quantification methods.

17.68% Efficiency Nonhalogenated Solvent-Processed Organic Solar Cell Modules Driven by Seed Crystal Strategy.

Organic solar cells now surpass 20% efficiency in small-area devices, but the use of chloroform as a solvent poses industrial scalability challenges because of its limited ability of uniform film formation and toxicity. High-boiling, non-halogenated solvents are being studied as alternatives, but their low solubility and slow evaporation complicate crystallization process. Here, the study introduces a seed crystal strategy by incorporating oligo (ethylene glycol)-modified small-molecule donors to optimize the nucleation and crystallization.

Advances in Processing Techniques and Determinants of Sweet Potato Starch Gelatinization.

Sweet potato starch is an important source of starch in food processing, but its natural functionality is relatively limited, restricting its performance in certain applications. Gelatinized sweet potato starch, with enhanced structural and functional properties, has broader potential applications in food products. During the gelatinization process, the crystalline structure of sweet potato starch changes, making it suitable for use in various food formulations.

Gender Differences in Self-Reported Social Participation in Adults With Autism.

There is a lack of research on gender differences in adults' with autism participation in social activities (i.e., activities that provide interactions with others in the community).

New Dawn in the Treatment of Rheumatoid Arthritis: Advanced Insight into Polymer Hydrogel Research.

As a chronic systemic autoimmune disease, rheumatoid arthritis (RA) not only damages joints and other organs or systems throughout the body but also torments patients' physical and mental health for a long time, seriously affecting their quality of life. According to incomplete statistics at present, the global prevalence of RA is approximately 0.5-1%, and the number of patients is increasing year by year.