Local therapy involving injectable hydrogel systems loaded with doxorubicin (DOX) has garnered significant attention in the realm of osteosarcoma (OS) research. Nevertheless, it has been noted that the local delivery of high-dose DOX exerts a pronounced inhibitory impact on osteogenesis, which is detrimental to the restoration of functional capabilities after OS treatment. To address this challenge, we have designed a self-assembled injectable hydrogel system that integrates photodynamic and chemodynamic therapy, aiming to enhance efficacy while mitigating adverse effects on osteogenic differentiation.
View Article and Find Full Text PDFLiquid-liquid phase separation (LLPS) of nuclear pore complex (NPC) with nuclear transport proteins (NTPs) via intrinsically disordered regions (IDRs) plays a crucial role in the nucleocytoplasmic transport. The development of efficient targeted delivery systems based on LLPS has attracted widespread attention. Here, we developed nanocarriers of casein peptides, a natural intrinsically disordered proteins (IDPs), modified with fatty acids of different alkyl chains (C10-C18) and decorated by shellac for highly effective drug delivery and cancer therapy.
View Article and Find Full Text PDFExcessive intake of a high fat diet (HFD) leads to accumulation of fat and obesity. Ergosterol (ERG) is a characteristic sterol of fungi with various bioactive functions; however, there are few studies on the ERG function of ameliorating obesity and following cognitive impairment. It was previously found that Zhashui (AA) is rich in ERG; therefore it was selected to enrich ERG through the intervention of exogenous inducers of rice bran oil (RBO), methyl jasmonate (Me JA) and salicylic acid (SA).
View Article and Find Full Text PDFAims: Migraine is a prevalent and incapacitating condition. The association between patent foramen ovale (PFO) and migraine-type headaches has been extensively documented. In clinical practice, patients may observe residual shunting after PFO closure.
View Article and Find Full Text PDFObjective: This study aimed to identify body mass index (BMI) growth trajectories from birth to 24 months of age and examine the independent and additive effects of four maternal metabolic risk factors, namely prepregnancy BMI, the rate of gestational weight gain, gestational diabetes mellitus (GDM) and gestational hypertension, on offspring growth trajectories in childhood in China.
Design: A retrospective cohort study was conducted.
Setting: The study used Maternal and Child Health Management Database in Chengdu, China, including the mothers' antenatal care data, birth certificate records and 0-3-year-old children's healthcare data.
In maritime operations, individuals often face the threat of combined injury caused by airblast overpressure and seawater immersion. Airblast overpressure, induced by explosions, leads to significant internal damage despite the absence of visible open wounds. Seawater immersion exacerbates injuries due to its high osmolarity, microbial content, and thermal conductivity.
View Article and Find Full Text PDFTop Stroke Rehabil
March 2025
Objective: Executive dysfunction after stroke greatly affects stroke prognosis, so clinicians need to urgently focus on screening for it. This study aims to offer valuable data for research on post-stroke executive dysfunction by evaluating the test-retest reliability of the Shape Trail Test (STT) and the influence of the practice effect on scores among stroke patients.
Methods: A total of 75 subacute stroke patients were included in the study.
Inflammatory myofibroblastic tumor (IMT) is a rare spindle-cell neoplasm. IMT currently suffers from a paucity of standardized diagnostic and therapeutic guidelines. The Chinese expert consensus committee on the diagnosis and treatment of IMT formed an "Expert consensus on the diagnosis and treatment of inflammatory myofibroblastic tumor".
View Article and Find Full Text PDFAbnormal alkaline phosphatase (ALP) levels in the human body are closely associated with various diseases, particularly hepatobiliary diseases and bone diseases. Herein, we constructed a ratiometric sensor based on Förster resonance energy transfer (FRET) using strongly photoluminescent copper nanoclusters (Cu NCs) for the detection of ALP with high sensitivity and specificity. The cysteine-stabilized Cu NCs (Cys-Cu NCs) were synthesized through a ligand-exchange reaction and core-size etching focusing, which displayed bright photoluminescence (PL) with a quantum yield (QY) of 10.
View Article and Find Full Text PDFUltrasound images and biological indicators, which reveal Hashimoto's thyroiditis (HT) characteristics in thyroid tissue from different perspectives, play crucial roles in HT recognition. Ultrasound images of patients with HT typically present a heterogeneous background with potential decreases in echogenicity. Clinicians are prone to misdiagnosing HT by visually evaluating these characteristics.
View Article and Find Full Text PDFFront Plant Sci
February 2025
The paper aims to slove the problems of low sowing depth qualification index and poor seeding stability during in summer direct-sown cotton in the Yangtze River Basin China. To this end, a cotton seeder with rotary tillage and electric drive seeding was designed. In order to satisfy the agronomic requirements of summer direct-sown cotton, the key structural parameters of this planter were determined, and the key factors affecting the stability of seeding depth were derived.
View Article and Find Full Text PDFNatural sesquiterpenoids possess a variety of skeleton types with intriguing biomedical activities. In this study, a comprehensive chemical study of the endophytic fungus 2021CDF-3 yielded a new sesquiterpenoid, namely penicivetivane A (). The chemical structure for was thoroughly ascertained by using HRESIMS and NMR spectroscopic analyses, while the stereochemistry of was further verified by X-ray diffraction analyses.
View Article and Find Full Text PDFWater contaminated with heavy metal ions poses serious threat to the human health and environment protection. It is imperative to develop analytical tools to detect heavy metal ions. Herein, we propose autofluorescence free SiO modified upconversion nanosensor for label-free and fast determination of MnO and CrO anions.
View Article and Find Full Text PDFSquid, which occupy a similar role to teleost fish as open water predators, are opportunistic foragers. However, there is a lack of empirical evidence related to whether individual squid specialize their diets to optimize fitness. We investigated whether individual squid have specialized diets and what factors impact any specialization using the Argentine shortfin squid as a case study species, coupled with a meta-analysis for other squid species.
View Article and Find Full Text PDFIEEE J Biomed Health Inform
November 2024
Prediction of drug-target interactions (DTIs) is one of the crucial steps for drug repositioning. Identifying DTIs through bio-experimental manners is always expensive and time-consuming. Recently, deep learning-based approaches have shown promising advancements in DTI prediction, but they face two notable challenges: (i) how to explicitly capture local interactions between drug-target pairs and learn their higher-order substructure embeddings; (ii) How to filter out redundant information to obtain effective embeddings for drugs and targets.
View Article and Find Full Text PDFMini/Micro LED is a new display technology, it has advantages of long-life, energy-saving, fast response speed and brightness. The mass transfer speed of Mini/Micro LED is main challenge for its large-scale application. Magnetic levitation platform with long stroke is vital to increase the mass transfer speed.
View Article and Find Full Text PDFSpinal cord injury (SCI) is a devastating disease with limited treatment options due to the restricted regenerative capacity of the central nervous system. The accumulation of reactive oxygen species (ROS) and inadequate endogenous neural stem progenitor cells (eNSPCs) in the lesion site exacerbates neurologic deficits and impedes motor function recovery. We have developed a temperature-responsive hyaluronic acid conjugated hydrogel-polydopamine nanoparticles (PDA NPs) combined with human mesenchymal stem cell (hMSCs) transplantation, denoted as H-P-M hydrogel.
View Article and Find Full Text PDFACS Appl Mater Interfaces
March 2025
Mesenchymal stem cells (MSCs) play a critical role in stem cell therapy due to their tissue-mimicking abilities. However, conventional 2D culture conditions often lead to the loss of their native hypoxic niche, potentially limiting their therapeutic efficacy. 3D bioprinting offers a method to recreate intricate biological environments by integrating cells with extracellular matrices.
View Article and Find Full Text PDFEdible maize is an important food crop, providing energy and nutrients to meet human health and nutritional requirements. However, how environmental pressures and human activity have shaped the edible maize metabolome remains unclear. In this study, we collected 452 diverse edible maize accessions worldwide, comprising waxy, sweet, and field maize.
View Article and Find Full Text PDFProtein synthesis could control spermatogenic cell fate transitions. Here, we present a protocol for visualization and quantification of newly synthesized proteins by click-chemistry-based immunofluorescence within specific spermatogenic cell types in the mice testicular lumen. We detail the processes for O-propargyl-puromycin (OPP) incorporation, antibody incubation, confocal microscope imaging, and subsequent quantification methods.
View Article and Find Full Text PDFOrganic solar cells now surpass 20% efficiency in small-area devices, but the use of chloroform as a solvent poses industrial scalability challenges because of its limited ability of uniform film formation and toxicity. High-boiling, non-halogenated solvents are being studied as alternatives, but their low solubility and slow evaporation complicate crystallization process. Here, the study introduces a seed crystal strategy by incorporating oligo (ethylene glycol)-modified small-molecule donors to optimize the nucleation and crystallization.
View Article and Find Full Text PDFSweet potato starch is an important source of starch in food processing, but its natural functionality is relatively limited, restricting its performance in certain applications. Gelatinized sweet potato starch, with enhanced structural and functional properties, has broader potential applications in food products. During the gelatinization process, the crystalline structure of sweet potato starch changes, making it suitable for use in various food formulations.
View Article and Find Full Text PDFAm J Intellect Dev Disabil
March 2025
There is a lack of research on gender differences in adults' with autism participation in social activities (i.e., activities that provide interactions with others in the community).
View Article and Find Full Text PDFAs a chronic systemic autoimmune disease, rheumatoid arthritis (RA) not only damages joints and other organs or systems throughout the body but also torments patients' physical and mental health for a long time, seriously affecting their quality of life. According to incomplete statistics at present, the global prevalence of RA is approximately 0.5-1%, and the number of patients is increasing year by year.
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