Chemical exposure in females of childbearing age associated with sex hormones: Evidence from an untargeted exposomic approach.

Exposure to organic chemicals can cause reproductive hormones disturbance in women. However, there is very limited evidence regarding real-world chemical exposures in reproductive-aged women and their joint effects on sex hormone levels. Here, we applied non-targeted screening workflow based on High-Performance Liquid Chromatography-High-Resolution Mass Spectrometry to investigate the serum chemical exposome of 156 women of childbearing age from Jinan, China.

Antibiotics in ambient fine particulate matter from two metropolitan cities in China: Characterization, source apportionment, and health risk assessment.

Excessive production and widespread application of antibiotic has led to residues in environmental matrices worldwide. There is limited knowledge of the concentrations of antibiotics bound to ambient fine particulate matter (PM) and their health risks. We investigated the occurrence, sources, environmental driving factors, and health risks of antibiotics in PM samples collected from Beijing and Shijiazhuang, China, during periods of high air pollution.

A critical review of human internal exposure to short-chain chlorinated paraffins and its concerning health risks.

Short-chain chlorinated paraffins (SCCPs) are a complex mixture of chlorinated derivatives of n-alkanes with a chain length of 10-13 carbon atoms. SCCPs have been extensively used in industrial applications, although an alarming concern is increasingly raised in hazarding environmental matrices and biological organisms due to the environmental persistence, bioaccumulation potential, biotoxicity, and long-range atmospheric transport. Herein, this study conducted a critical review of human internal exposure to SCCPs and its concerning health risks by thoroughly analyzing 63 relevant articles screened in online databases, including the Web of Science, PubMed, Elsevier ScienceDirect, and China National Knowledge Infrastructure (CNKI).

Finding a rhythm: The mediality of researching digital skill as process.

Our objective for this article is to illustrate the importance of understanding digital skill as process by taking its mediality-interweaving tools, technologies, and media-into consideration. Drawing on 12 case studies with participants performing digital tasks, we use Ingold's four phases of skill (getting ready, setting out, carrying on, and finishing off) to research and represent the rhythm of digital skill. By using medialities of inscription, scripting, and annotation, we demonstrate how researchers can use mediality to perceive rhythms of digital skill without being physically co-located in the performance.

Exposure profiles, determinants, and health risks of chemicals in personal care products among healthy older adults from the China BAPE study.

Personal care products (PCPs) are ubiquitously present in the environment, and the associated health risks have been increasingly concerned worldwide. However, knowledge regarding exposure assessments of older adults to these chemicals and their health risks remains largely limited. In the present study, five repeated surveys involving 76 healthy older adults in Jinan, Shandong Province, were performed to quantify urinary exposure levels of 14 chemicals in PCPs.

Effective prediction of organosilicon molecular structures and risks in aquatic environment with machine learning.

Until now, mass spectrometry databases lack molecular information of most organosilicon oligomers, and risk models needing accurate molecular descriptors are unavailable for these emerging contaminants with thousands of monomers. To address this issue, based on molecular/fragment ions and relative abundance from GC-Orbitrap-MS, this study developed appropriate classification (accuracies = 0.750-0.

Reproductive toxicity of bisphenol A and nitro-bisphenol A in male zebrafish at environmentally relevant concentrations.

Bisphenol A (BPA) is a well-known endocrine-disrupting pollutant that poses significant environmental challenges globally. However, the toxicity of nitro-BPA (NBPA), the primary transformation product of BPA, remains poorly understood. This study employs a multi-omics approach, integrating in silico and bioinformatics analyses, to investigate and compare the male reproductive toxicity of BPA and NBPA in male zebrafish exposed to environmentally relevant concentrations.

Quantum efficiency enhancement of reflective GaAs photocathodes with exponential-doping structure generating a favorable built-in electric field.

The rapid development of GaAs photocathodes has led to an increased focus on the attainment of high quantum efficiency. Three types of exponential-doping structures with a high to low doping concentration distribution from the interior to the surface are proposed for reflective GaAs emission layers. These three structures generate different built-in electric fields that facilitate photoelectron emission.

Evaluation of various mass spectrometry mode based on gas chromatography for quantifying the polycyclic aromatic hydrocarbon metabolites in human urine.

Hydroxyl polycyclic aromatic hydrocarbons (OH-PAHs) are frequently used as biomarkers to assess human exposure to polycyclic aromatic hydrocarbons (PAHs), which are typically present in minute concentrations in the human body. Although several studies have outlined methods for measuring OH-PAHs in human urine, these approaches may have limitations concerning the range of compounds detected, the sample volume required for pre-treatment, accuracy, and instrument maintenance costs. Advances in mass spectrometry technology have facilitated the use of various mass spectrometry modes based on gas chromatography.

Deciphering the anthocyanin metabolism gene network in tea plant (Camellia sinensis) through structural equation modeling.

Background: Tea is an important cash crop that significantly contributes to rural development, poverty reduction and food security in many developing countries. It provides livelihoods for millions of smallholder producers and aids their economic stability. Anthocyanins in tea leaves provides excellent commercial quality and germplasm exploration potential.

Balancing Growth and Defense: Nanoselenium and Melatonin in Tea () Protection against Glufosinate.

Current crop stress resistance research suggests that the prominent stimulants nanoselenium (NSe) and melatonin (MT) might improve tea safety, quality, and stress resistance induced by the widely used nonselective herbicide glufosinate (GLU). Their biofortification effects on tea growth, antioxidant activity, and secondary metabolism pathways response to GLU remain unclear. Here, NSe, MT, and their combination NSe-MT effectively reduced 26.

Distinct effects of dilute acid prehydrolysate inhibitors on enzymatic hydrolysis and yeast fermentation.

The effects of dilute acid prehydrolysate from poplar were investigated and compared in the enzymatic hydrolysis, fermentation, and simultaneous saccharification fermentation (SSF) in this study. The improvement of enzymatic hydrolysis and fermentation with resin adsorption and surfactant addition has also been represented. A total of 16 phenolic alcohols, aldehydes, acids and 3 furan derivatives in the prehydrolysates were identified and quantified by gas chromatography/mass spectrometry (GC/MS).

Burden of non-communicable diseases due to population ageing in China: challenges to healthcare delivery and long term care services.

China has made substantial progress in healthcare delivery to reduce the burden of non-communicable diseases due to population ageing, although challenges and opportunities in long term care services have been under-recognised, argue

Novel scoring system incorporating lipoproteins to predict outcomes of epithelial ovarian cancer patients.

Objective: Epithelial ovarian cancer is the most lethal gynecological malignancy worldwide. While common prognostic factors are identified, the impact of serum lipoproteins remains controversial. This retrospective cohort study aims to investigate the association between specific lipoprotein levels and prognosis.

Graphene Intermediate Layer for Robust and Spectrum-Extended Cu Photocathode Activated with Cs and O.

Developing an effective method to stably enhance the quantum efficiency (QE) and extend the photoemission threshold of Cu photocathodes beyond the ultraviolet region could benefit the photoinjector for ultrafast electron source applications. The implementation of a 2D material protective layer is considered a promising approach to extending the operating lifetime of photocathodes. We propose that graphene can serve as an intermediate layer at the interface between photocathode material and low-work-function coating.

Multigenerational effects of disperse blue 79 at environmentally relevant concentrations on zebrafish (Danio rerio) fecundity: An integrated approach.

The brominated azo dye (BAD) Disperse Blue (DB79) is a widespread environmental pollutant. The long-term toxicological effects of DB79 and the mechanisms thereof must be understood to allow assessment of the risks of DB79 pollution. A dual-omics approach employing in silico analysis, bioinformatics, and in vitro bioassays was used to investigate the transgenerational (F-F) toxicity of DB79 in zebrafish at environmentally relevant concentrations and identify molecular initiating events and key events associated with DB79-induced fertility disorders.

Experimental Study of the Flexural Performance of GFRP-Reinforced Seawater Sea Sand Concrete Beams with Built-In GFRP Tubes.

The use of seawater sea sand concrete (SSSC) and fiber-reinforced polymer (FRP) has broad application prospect in island and coastal areas. However, the elastic modulus of FRP reinforcement is obviously lower than that of ordinary steel reinforcement, and the properties of SSSC are different from that of ordinary concrete, which results in a limit in the bearing capacity and stiffness of structures. In order to improve the flexural performance of FRP-reinforced SSSC beams, a novel SSSC beam with built-in glass FRP (GFRP) tubes was proposed in this study.

High-Entropy Alloy Activating Laves-Phase Network for Multi-Component Metallic Coatings with High Hardness.

The low hardness and poor wear resistance of laser-cladding 316L stainless steel impose significant constraints on its practical applications. In this study, a strategy for strengthening laser-cladding 316L stainless steel with WMoTaNb refractory high-entropy alloy as a reinforcement material is proposed. The results confirm that the coating primarily comprises a body-centered cubic (BCC) Fe-based solid solution, a network-distributed hexagonal FeX (X = W, Mo, Ta, and Nb) Laves phase, and a diffusely distributed face-centered cubic (FCC) (Ta, Nb)C phase.

Co-production of fermentable sugars and highly active lignin from eucalyptus via a mild preprocessing with diethylene glycol and chromic chloride.

Eucalyptus was pretreated with diethylene glycol catalyzed by 0.02 mol/L CrCl for 10 min, resulting in 91 % delignification and 98 % cellulose recovery, with trace fermentation inhibitors generated. After the mild pretreatment, the accessibility and affinity of cellulase to eucalyptus was enhanced, especially since enzyme adsorption rate increased by 1.