Publications by authors named "Song Stephen Yi"
Article Synopsis
- - Alzheimer's Disease (AD) is an irreversible condition that leads to cognitive decline, marked by amyloid plaques and neurofibrillary tangles in the brain.
- - The FDA has approved three monoclonal antibodies (aducanumab, lecanemab, and donanemab) for mild cognitive impairment and mild AD, alongside traditional treatments like acetylcholinesterase inhibitors.
- - Future research should concentrate on combining therapies that target both amyloid plaques and tau pathology to enhance treatment efficacy.
It is increasingly appreciated that long non-coding RNAs (lncRNAs) associated with alternative splicing (AS) could be involved in aggressive hepatocellular carcinoma. Although many recent studies show the alteration of RNA alternative splicing by deregulated lncRNAs in cancer, the extent to which and how lncRNAs impact alternative splicing at the genome scale remains largely elusive. We analyzed RNA-seq data obtained from 369 hepatocellular carcinomas (HCCs) and 160 normal liver tissues, quantified 198,619 isoform transcripts, and identified a total of 1,375 significant AS events in liver cancer.
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