Aberrant brain structural-functional coupling and structural/functional network topology explain developmental delays in pediatric Prader-Willi syndrome.

Prader-Willi syndrome (PWS) is a neurodevelopmental disorder characterized by dysplasia in early life. Psychoradiology studies have suggested that mental and behavioral deficits in individuals with PWS are linked to abnormalities in brain structural and functional networks. However, little is known about changes in network-based structural-functional coupling and structural/functional topological properties and their correlations with developmental scales in children with PWS.

Novel Selectivity: Target of Gas Sensing Defined by Behavior.

Traditional selectivity of gas sensors determined by the magnitude of the response value has significant limitations. The distinctive inversion sensing behavior not only defies the traditional sensing theory but also provides insight into defining selectivity. Herein, the novel definition of selectivity is established in a study with VO(M1).

Endoscopic ultrasound-guided biliary drainage percutaneous transhepatic biliary drainage for malignant biliary obstruction after endoscopic retrograde cholangiopancreatography failure.

In a recent issue of the , a meta-analysis investigated the safety and efficacy of electrocautery-enhanced lumen-apposing metal stent (ECE-LAMS) implantation for managing malignant biliary obstruction following failed endoscopic retrograde cholangiopancreatography. This manuscript endeavors to offer a comprehensive look at the progression of endoscopic ultrasound-guided biliary drainage (EUS-BD) technologies, weighing their merits and drawbacks against traditional percutaneous methods. Several meta-analyses and randomized controlled trials have compared the performance of EUS-BD and percutaneous transhepatic cholangiodrainage (PTCD).

Hepatic arterial infusion chemotherapy plus regorafenib compared with regorafenib alone as second-line therapy for advanced hepatocellular carcinoma: a randomised controlled trial protocol.

Introduction: The exact role of hepatic arterial infusion chemotherapy (HAIC) in advanced hepatocellular carcinoma (aHCC) is still unknown. The combination of HAIC and sorafenib has been proven to be more effective than sorafenib alone in the first-line treatment of aHCC. The aim of the study is to evaluate the efficacy and safety of HAIC plus regorafenib in the second-line treatment of aHCC.

Advancing knowledge of One Health in China: lessons for One Health from China's dengue control and prevention programs.

Background: The emergence of dengue fever has prompted significant public health responses, highlighting the need for a comprehensive understanding of One Health in addressing vector-borne diseases. China's experience in dengue control and prevention programs offers valuable insights into the successful integration of multidisciplinary strategies.

Aims: The review aims to: (1) systematically analyze lessons from China's dengue control and prevention programs, focusing on the integration of these efforts with the One Health approach; (2) underscore the reasons of optimizing the dengue control and prevention program; (3) highlight the alignment of China's dengue control strategies with the One Health framework; (4) contribute to global efforts in combating dengue, providing scientific evidence and strategic recommendations for other regions facing similar challenges.

A butterfly metasurface with efficient multi-functional polarization conversion operating in the Ku-Ka band.

A highly efficient and multi-functional butterfly polarization conversion metasurface is proposed for the Ku-Ka frequency range, designed to reduce the radar cross-section. The suggested converter enables dual frequency bands linear-to-cross (LX) and linear-to-circular (LC) polarization transformations. The efficiency of cross-polarization conversion exceeds 90% over the frequency ranges of 14.

Natural products: promising therapeutics for targeting regulatory immune cells in the tumor microenvironment.

Regulatory immune cells regulate immune responses through various mechanisms, affecting the occurrence, development, and therapeutic effects of tumors. In this article, we reviewed the important roles of regulatory immune cells, such as regulatory T cells (Tregs), regulatory B cells (Bregs), myeloid-derived suppressor cells (MDSCs), regulatory dendritic cells (DCregs), and tumor-associated macrophages (TAMs), in the tumor microenvironment (TME). The immunomodulatory effects of natural products, such as polysaccharides, polyphenols, glycosides, alkaloids, terpenoids, quinones, and other compounds, which affect the functions of regulatory immune cells through molecular signaling pathways, thereby enhancing the potential of the antitumor immune response, are discussed.

Matrix Metalloproteinase-Responsive Controlled Release of Self-Assembly Nanoparticles Accelerates Heart Valve Regeneration In Situ by Orchestrating Immunomodulation.

In situ tissue engineering heart valves (TEHVs) are the most promising way to overcome the defects of existing valve prostheses. Despite their promising prospects, the clinical translation of TEHVs remains a formidable challenge, mainly due to unpredictable host interactions post-implantation. An immunomodulatory idea based on hydrogel encapsulation of nanoparticle-coated heart valve scaffolds is introduced.

CsPbBr Quantum Dot Modified InO Nanofibers for Effective Detection of ppb-Level HCHO at Room Temperature under UV Illumination.

The design of high-performance and low-power formaldehyde (HCHO) gas sensors is of great interest to researchers for environmental monitoring and human health. Herein, InO/CsPbBr composites were successfully synthesized through an electrospinning and self-assembly approach, and their ultraviolet-activated (UV-activated) HCHO gas-sensing properties were investigated. The measurement data indicated that the InO/CsPbBr sensor possesses an excellent selectivity toward HCHO.

In-depth analysis of the roles and mechanisms of sulfate radical and hydroxyl radical in the degradation of metal-cyanide complexes.

Persulfate-based advanced oxidation processes (PS-based AOPs), characterized by the coexistence of SO₄•⁻ and HO•, have been proven effective in treating a series of cyanide-bearing pollutants. However, the mechanisms of these reactive species in the degradation of cyanides, especially metal-cyanide complexes, remain unclear or contradictory. The degradation behavior of representative cyanides (including potassium cyanide and potassium ferricyanide) at different pH conditions (2, 7 and 12) in thermally activated persulfate system (T = 60 °C) was explored, and the roles of SO₄•⁻ and HO• in cyanide degradation were explored by leveraging the distinct characteristics of reactive species under different pH conditions.

Teachers' authoritarian leadership and students' well-being: the role of emotional exhaustion and narcissism.

Background: Teachers' leadership styles have a significant impact on students' academic performance, physical health and mental health. Authoritarian leadership, as a typical leadership style, is prevalent in the teacher community. The purpose of this study was to examine the mechanisms by which authoritarian leadership impacts students' well-being.

Folic acid modified silver nanoparticles promote endothelialization and inhibit calcification of decellularized heart valves by immunomodulation with anti-bacteria property.

Xenogeneic decellularized heart valves (DHVs) have become one of the most commonly used scaffolds for tissue engineered heart valves (TEHVs) due to extensive resources and possessing the distinct three-layer structure similar to native heart valves. However, DHVs as scaffolds face the shortages such as poor mechanical properties, proneness to thrombosis and calcification, difficulty in endothelialization and chronic inflammatory responses etc., which limit their applications in clinic.

Self-calibrated paper-based nanoarrays for background-free quantitative detection of pesticides using self-assembly and mask-assisted techniques.

Flexible surface-enhanced Raman scattering (SERS) has received considerable attention in the field of rapid analysis. However, obtaining accurate quantitative SERS results remains challenging. Here, we develop a SERS sensor based on self-assembly and mask-assisted techniques for the precise transfer of Au@PB@Ag nanoarrays onto filter paper.

Molecular engineering and structure-property relationship based on D-A chlorophyll derivative and the application in organic solar cells.

The photoactive layer materials of organic solar cells (OSCs) play a critical role in achieving excellent performance. Chlorophyll derivatives are commonly used due to their environmental friendliness, low cost, and easy accessibility. However, the efficiency of OSCs based on chlorophyll is limited by their photoelectric properties.

Optical absorption spectroscopy and electronic properties of D-A dyes and chlorophyll derivatives for co-sensitization in DSSCs.

The photophysical and photochemical processes of the experimental dyes ZS11 and ZS12 containing phenyl-cyanoacrylic acid (PCA) and ethynyl-PCA (EPCA) group were studied by DFT and TD-DFT systems to develop their applications in solar cells. First, their geometry, absorption spectra, chemical reaction parameters, electron transfer and dye activity were systematically studied. The photoelectric conversion efficiency (PCE) was predicted, and it was found that the PCE of ZS12 (9.

Relationship between phosphorus stoichiometric homeostasis and deepwater adaptability of submerged macrophytes in Erhai Lake, China: Insights from allometric plasticity.

The state transition theory suggests that the decline of submerged macrophytes in shallow lakes is closely associated with reduced stoichiometric homeostasis, particularly phosphorus homeostasis (H). The degradation typically progresses from deeper to shallower regions, indicating a potential positive correlation between the deepwater adaptability (DA) and H values of submerged macrophytes. Here, we investigated the distribution pattern of submerged macrophytes across different water depths of Erhai Lake to test this hypothesis.

Association between glymphatic dysfunction and neurocognitive decline in patients with frontal lobe epilepsy.

Background: The glymphatic system is essential for the maintenance of brain homeostasis. It may be impaired in patients with epilepsy, but its association with neurocognitive function remains unknown. In this study, we aimed to elucidate the association between changes in the glymphatic system and neurocognitive function in individuals diagnosed with frontal lobe epilepsy (FLE).

Fabrication of core-shell-like bimetallic SERS substrates with inter-coordination effect for catalysis of -mercaptoaniline.

The present study discusses the core-shell structures of Au@Ag prepared by a seed-growth method. The morphology and composition of Au@Ag nanoparticles were analyzed, indicating that they were successfully prepared. By studying the surface-enhanced Raman scattering spectra (SERS) of -mercaptoaniline (PATP) molecules adsorbed on Au@Ag substrates, it was found that PATP molecules could be oxidized to form -mercaptoazobenzene (DMAB) on Au@Ag substrates, indicating that the gold-silver bimetallic nanomaterials could catalyze the PATP molecules with excellent enhancement effect and stability.

TESMIN is a Prognostic Biomarker Associated with Immunosuppression and Activated Cell Cycle in Lung Adenocarcinoma.

Background: The Testis Expressed Metallothionein Like Protein (TESMIN) gene encodes highly conserved, cysteine-rich, low-molecular proteins that are activated by and have an affinity for heavy metal ions. Previous literature has shown its association with cancer. Nevertheless, no thorough bioinformatics analysis of TESMIN has been done yet in lung adenocarcinoma (LUAD).