[Gender differences in antidepressant effect of raw Rehmanniae Radix].

For the first time, this study evaluated the gender differences and mechanisms of the antidepressant effects of raw Rehmanniae Radix(RRR) based on the classic depression model with traditional Chinese medicine syndrome of Yin deficiency and internal heat. The depression model with Yin deficiency and internal heat was established by the widely recognized and applied method of thyroxine induction of the classic depression model with Yin deficiency and internal heat(chronic unpredictable mild stress). Male and female mice were simultaneously treated with RRR.

Association between prenatal exposure to per- and polyfluoroalkyl substances and neurodevelopment in children: Evidence based on birth cohort.

Background: Although numerous studies have examined the effect of prenatal per- and polyfluoroalkyl substances (PFAS) exposure on neurodevelopment in children, findings have been inconsistent.

Objective: To better understand the effects of PFAS exposure during pregnancy on offspring neurodevelopment, we conducted a systematic review of prenatal exposure to different types of PFAS and neurodevelopment in children.

Methods: A comprehensive search was conducted in the PubMed, Web of Science, and EMBASE electronic databases up to March 2023.

[Toxicity attenuation processing technology and mechanism of Rhizoma Dioscoreae Bulbiferae stir-fried with Paeoniae Radix Alba decoction].

This study explored toxicity attenuation processing technology of Rhizoma Dioscoreae Bulbiferae stir-fried with Paeoniae Radix Alba decoction for the first time, and further explored its detoxification mechanism. Nine processed products of Rhizoma Dioscoreae Bulbiferae stir-fried with Paeoniae Radix Alba decoction were prepared by orthogonal experiment with three factors and three levels. Based on the decrease in the content of the main hepatotoxic component diosbulbin B before and after processing of Rhizoma Dioscoreae Bulbiferae by high-performance liquid chromatography, the toxicity attenuation technology was preliminarily screened out.

Association between the dietary literacy of children's daily diet providers and school-age children's nutritional status and eating behaviours: a cross-sectional study.

Background: Overweight and obesity rates have increased rapidly in Chinese school-age children, and previous studies have indicated that poor dietary literacy can lead to unhealthy eating behaviours. However, few studies have investigated the association between the dietary literacy of daily diet providers and the eating behaviours and nutritional status of school-age children raised by the providers. Thus, we aimed to explore this association.

Association between pyrethroid exposure and risk of depressive symptoms in the general US adults.

This study aimed to investigate the association between pyrethroid exposure and the risk of depressive symptoms in adults in the USA. Data of participants aged ≥20 years (n = 6455) from the National Health and Nutrition Examination Survey (NHANES, 2007-2014) were included. 3-Phenoxybenzoic acid (3-PBA), an adequately detected pyrethroid metabolite, was used as a biomarker to assess pyrethroid exposure.

[Preliminary exploration of detoxification mechanism of processing methods on cardiotoxicity induced by radix Tripterygium wilfordii in mice via Nrf2/HO-1 pathway].

This study aims to investigate the detoxification effects of different processing methods on the cardiotoxicity induced by radix Tripterygium wilfordii, and preliminarily explore the detoxification mechanism via the nuclear factor E2-related factor 2(Nrf2)/heme oxygenase 1(HO-1) pathway. The raw and processed products [stir-fried product, product stir-fried with Lysimachiae Herba(JQC), product stir-fried with Phaseoli Radiati Semen(LD), product stir-fried with Paeoniae Radix Alba(BS), product stir-fried with Glycyrrhizae Radix et Rhizoma(GC), and product stir-fried with vinegar(CZ)] of radix T. wilfordii were administrated to mice by gavage at a dose of 2 g·kg~(-1)(based on crude drugs) for 28 days.

Hydrochemical patterns indicating hydrological processes with the background of changing climatic and environmental conditions in China: a review.

In the background of global climate and environmental change, the hydrochemical characteristics of water bodies present significant instability to all regions, including humid, arid, and alpine ones. There are two main reasons for this: (1) climate change has altered the temporal and spatial distribution of precipitation, and climate warming intensified the mutual transformation of water bodies. The temperature in China increased by 0.

[Processing technology for reducing toxicity of fried Tripterygium wilfordii in Lysimachia christinae decoction].

On the basis of the previous work of the research group, the orthogonal design method was further used to optimize the processing technology for reducing toxicity of fried Tripterygium wilfordii in Lysimachia christinae Decoction. A total of 9 processed products of T.wilfordii in L.

The role of GLP-1/GIP receptor agonists in Alzheimer's disease.

Background: New glucagon-like peptide-1 (GLP-1) analogues developed in recent years have a long half-life and offer further prospects for clinical application. At present, the neuroprotection of GLP-1 analogues in Alzheimer's disease (AD) has just begun to be explored.

Objectives: To investigate how glucagon-like peptide-1 (liraglutide) plays a protective role in AD by regulating tau activation and BACE1 expression.

Transformation mechanism of ions on different waters in alpine region.

The study investigates transformation mechanism of ions on different waters in Alpine region through analyzed the hydrochemical characteristics of the major ions of precipitation, glacier and snow meltwater, supra-permafrost water and river water in permafrost regions in the Tibetan Plateau under climate warming. The results showed that, The relation between recharge and discharge was the major ways for ionic transformation of each water body. Precipitation and glacier and snow meltwater are the main input sources for ionic transformation, and river water is the final output source.

The sources of supra-permafrost water and its hydrological effect based on stable isotopes in the third pole region.

The sources of supra-permafrost water and its hydrological effects were studied, based on the presence of stable isotopes in 562 samples collected in different ablation periods from the source regions of the Yangtze River. The δO (δD and d-excess) values for the initial ablation, ablation, and end ablation periods were -10.18‰ (-71.

Response mode of hydrochemical types of river water to altitude gradient in alpine regions.

The study investigates the hydrochemical type and characteristics of river water in permafrost regions in the Tibetan Plateau by analyzing 532 samples collected from the source region of the Yangtze River. The hydrochemical type of the river water was Cl-Na-SO, and its hydrochemical characteristics were primarily influenced by the soil sources, though the influence of the sea sources and anthropogenic factors could not be ignored. Significant negative correlations were found between temperature and NO, SO, Mg, Ca, and between precipitation, relative humidity, and SO and Mg in the river water.

[Research progress in mineral Chinese medicine realgar].

Realgar is a mineral traditional medicine with definite efficacy. The function of realgar is detoxicating, insecticiding, eliminating dampness and phlegm, etc. It is widely applied in clinical practice by compatibility medicines.

Environment significance and hydrochemical characteristics of supra-permafrost water in the source region of the Yangtze River.

This paper analyzed the environment significance and hydrochemical characteristics of the main ions on the supra-permafrost water from the view of space-time and different ablations. The study is conducted through collected 330 samples from June to September in 2016 and 2017 in the Source Region of the Yangtze River (SRYR). The results showed the pattern of ionic dominance based on mean value was following as: Cl > Na > SO > Ca > Mg > K > NO > NO > NH > F > Li.

The clinical assessment of amyotrophic lateral sclerosis patients' prognosis by ZNF512B gene, neck flexor muscle power score and body mass index (BMI).

Background: Assessment on the prognosis of amyotrophic lateral sclerosis (ALS) is becoming a focus of research in recent years since there is no effective treatment. The aim of the research is to explore the major factors involving in prognosis of ALS patients through long-term follow-up.

Methods: ALS patients' DNA extracted from peripheral blood white cells were detected for the risk allele by single nucleotide polymorphism (SNP) analysis.

Effect of RNA interference of the expression of HMGA2 on the proliferation and invasion ability of ACHN renal cell carcinoma cells.

This aim of the present study was to observe the effect of high mobility group AT‑hook 2 (HMGA2) on the proliferation and invasion ability of ACHN renal cell carcinoma (RCC) cells. Human ACHN cells, an RCC cell line, and HKC normal human renal tubular epithelial cells were cultured. HMGA2 small interfering (si)RNA, Mock‑siRNA and their negative control group were designed and synthesized.

[Significance of Thl7/Treg Ratio in aGVHD Occurence after Allo-HSCT].

Objective: To explore the relationship between Th17 and Treg levels and aGVHD occurence in patients after allo-HSCT.

Methods: Thirty-nine patients received allo-HSCT were divided into 2 groups: aGVHD group(17 cases) and non-aGVHD group (22 cases). For aGVHD group, the peripheral blood was collected before aGVHD occurence, in occurence and after aGVHD improvement; for non-aGVHD group, the peripheral blood was collected after 1, 2 and 3 months of transplantation.

[Environmental significance of wet deposition composition in the central Qilian Mountains, China].

A total of 90 precipitation samples were collected from individual precipitation events at the Qilian Alpine Ecology & Hydrology Research Station (Hulugou Station, 30 degrees 47'N, 90 degrees 58'E; 3 260 m a. s. l) located in the central Qilian Mountains from August 2012 to November 2013.

[Preparation and performance of through-hole AAO film].

Praseodymium nitrate was used as additives in preparing anodic aluminum oxide (AAO) films to improve its performance. AAO films were prepared by anodization method from a 15 vol. % H2SO4 solution with added praseodymium nitrate.

[Preparation and performance of controlled-release tablets of sasanquasaponin-casein].

The controlled-release tablets of sasanquasaponin (SQS)-casein were prepared by using SQS, casein and guar gum as the main drug and accessory materials respectively. The method of determination of SQS in the controlled-release tablets of SQS-casein, and the effects of release media on the release rate and IR spectra of the controlled-release tablets of SQS-casein were studied, respectively. The release rate curve of the controlled-release tablets of SQS-casein was fitted as zero order, one order and Higuchi equation.

Electrostatic spin crossover in a molecular junction of a single-molecule magnet Fe{2}.

Spin crossover by means of an electric bias is investigated by spin-polarized density-functional theory calculations combined with the Keldysh nonequilibrium Green's technique in a molecular junction, where an individual single-molecule magnet Fe{2}(acpybutO)(O{2}CMe)(NCS){2} is sandwiched between two infinite Au(100) nanoelectrodes. Our study demonstrates that the spin crossover, based on the Stark effect, is achieved in this molecular junction under an electric bias but not in the isolated molecule under external electric fields. The main reason is that the polarizability of the molecular junction has an opposite sign to that of the isolated molecule, and thus from the Stark effect the condition for the spin crossover in the molecular junction is contrary to that in the isolated molecule.

[Preparation of electrodeposited Cr-La coating and its spectral properties].

Cr-La coating (dc) and Cr-La coating (pulse) were prepared by electrodeposition method of direct current and pulsating current respectively. The Cr-La coating (dc) and Cr-La coating (pulse) were characterized with ICP-AES, EDAX, XRD and SEM techniques, respectively. Cr-La coating(dc) was amorphous.

A "GC-rich" method for mammalian gene expression: a dominant role of non-coding DNA GC content in regulation of mammalian gene expression.

High mammalian gene expression was obtained for more than twenty different proteins in different cell types by just a few laboratory scale stable gene transfections for each protein. The stable expression vectors were constructed by inserting a naturally-occurring 1.006 kb or a synthetic 0.

Design, recombinant expression, and antibacterial activity of the cecropins-melittin hybrid antimicrobial peptides.

In order to evaluate their antibacterial activities and toxicities, the cecropins-melittin hybrid antimicrobial peptide, CA(1-7)-M(4-11) (CAM) and CB(1-7)-M(4-11) (CBM), were designed by APD2 database. The recombinant hybrid antimicrobial peptides were successfully expressed and purified in Pichia pastoris. Antimicrobial activity assay showed that both of the two hybrid antimicrobial peptides had strong antibacterial abilities against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Bacillus subtilis, Bacillus thuringiensis, and Salmonella derby.