Publications by authors named "Song Ji-Wei"
CNTF induces Clcf1 in astrocytes to promote the differentiation of oligodendrocyte precursor cells.
Biochem Biophys Res Commun
December 2022
Article Synopsis
- - Neural stem cells (NSCs) are crucial for regeneration in the central nervous system but face challenges because of a harsh microenvironment, limiting their effectiveness in therapies.
- - Research indicates that NSCs engineered to overexpress ciliary neurotrophic factor (CNTF) show improved remyelination effects, but the exact mechanism is not fully understood.
- - The study reveals that CNTF-NSCs can induce astrocytes to produce cardiotrophin-like cytokine 1 (Clcf1), which promotes the differentiation of oligodendrocyte precursor cells, highlighting Clcf1 as a potential therapeutic target for demyelinating diseases.
Article Synopsis
- Macrophages and microglia are crucial for the body's response to spinal cord injuries, and modifying their behavior could aid recovery.
- Low-level laser therapy (LLLT) is a promising noninvasive treatment for neurotrauma, though its effects on macrophage/microglia polarization after spinal cord injury were previously unknown.
- The study found that LLLT shifted macrophage/microglia towards a protective state, improved neuron survival, enhanced recovery scores, and increased levels of beneficial cytokines like IL-4 and IL-13, suggesting its potential as a treatment for spinal cord injuries.